ID   METR_SALTY              Reviewed;         317 AA.
AC   P0A2Q4; P05984; Q9L6N2;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=HTH-type transcriptional regulator MetR;
GN   Name=metR; OrderedLocusNames=STM3964; ORFNames=STMD1.26;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3040668; DOI=10.1128/jb.169.9.3932-3937.1987;
RA   Plamann L.S., Stauffer G.V.;
RT   "Nucleotide sequence of the Salmonella typhimurium metR gene and the metR-
RT   metE control region.";
RL   J. Bacteriol. 169:3932-3937(1987).
RN   [2]
RP   SEQUENCE REVISION.
RA   Urbanowski M.;
RL   Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Control of the last step in methionine biosynthesis; MetR is
CC       a positive activator of the metA, metE and metH genes. It is also a
CC       negative regulator of its own expression.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; M17356; AAB88753.1; -; Genomic_DNA.
DR   EMBL; AF233324; AAF33428.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL22808.1; -; Genomic_DNA.
DR   RefSeq; NP_462849.1; NC_003197.2.
DR   RefSeq; WP_000569786.1; NC_003197.2.
DR   AlphaFoldDB; P0A2Q4; -.
DR   SMR; P0A2Q4; -.
DR   STRING; 99287.STM3964; -.
DR   PaxDb; P0A2Q4; -.
DR   EnsemblBacteria; AAL22808; AAL22808; STM3964.
DR   GeneID; 1255490; -.
DR   KEGG; stm:STM3964; -.
DR   PATRIC; fig|99287.12.peg.4182; -.
DR   HOGENOM; CLU_039613_6_0_6; -.
DR   OMA; YPVPDDM; -.
DR   PhylomeDB; P0A2Q4; -.
DR   BioCyc; SENT99287:STM3964-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   CDD; cd08441; PBP2_MetR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR037406; MetR_PBP2.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; Amino-acid biosynthesis; Cytoplasm; DNA-binding;
KW   Methionine biosynthesis; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..317
FT                   /note="HTH-type transcriptional regulator MetR"
FT                   /id="PRO_0000105676"
FT   DOMAIN          1..59
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        19..38
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   CONFLICT        152
FT                   /note="G -> E (in Ref. 1; AAB88753)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   317 AA;  35513 MW;  80A77A3D26355278 CRC64;
     MIEIKHLKTL QALRNSGSLA AAAAVLHQTQ SALSHQFSDL EQRLGFRLFV RKSQPLRFTP
     QGEVLLQLAN QVLPQISRAL QACNEPQQTR LRIAIECHSC IQWLTPALEN FRASWPQVEM
     DFTSGVTFDP QPALQQGELD LVMTSDILPR SGLHYSPMFD FEVRLVLAPD HPLASKTQIT
     PEDLASETLL IYPVQRSRLD VWRHFLQPAG ISPLLKSVDN TLLLIQMVAA RMGIAALPHW
     VVESVERQGL VVTKTLGDGL WSRLYAAVRD GDQRQAVTEA FIRSTRDHAC DHLPFVRSAE
     RPIFDAPTAK PGSQPRL