ID   METR_SHIFL              Reviewed;         317 AA.
AC   P0A9G1; P19797;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 115.
DE   RecName: Full=HTH-type transcriptional regulator MetR;
GN   Name=metR; OrderedLocusNames=SF3906, S3849;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Control of the last step in methionine biosynthesis; MetR is
CC       a positive activator of the metA, metE and metH genes. It is also a
CC       negative regulator of its own expression (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; AE005674; AAN45341.1; -; Genomic_DNA.
DR   EMBL; AE014073; AAP18857.1; -; Genomic_DNA.
DR   RefSeq; NP_709634.1; NC_004337.2.
DR   RefSeq; WP_000573621.1; NZ_WHSI01000049.1.
DR   AlphaFoldDB; P0A9G1; -.
DR   SMR; P0A9G1; -.
DR   STRING; 198214.SF3906; -.
DR   EnsemblBacteria; AAN45341; AAN45341; SF3906.
DR   EnsemblBacteria; AAP18857; AAP18857; S3849.
DR   GeneID; 1025727; -.
DR   GeneID; 66672264; -.
DR   KEGG; sfl:SF3906; -.
DR   KEGG; sfx:S3849; -.
DR   PATRIC; fig|198214.7.peg.4606; -.
DR   HOGENOM; CLU_039613_6_0_6; -.
DR   OrthoDB; 750230at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd08441; PBP2_MetR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR037406; MetR_PBP2.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; Amino-acid biosynthesis; Cytoplasm; DNA-binding;
KW   Methionine biosynthesis; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..317
FT                   /note="HTH-type transcriptional regulator MetR"
FT                   /id="PRO_0000105677"
FT   DOMAIN          1..59
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        19..38
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   CONFLICT        109
FT                   /note="E -> G (in Ref. 2; AAP18857)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   317 AA;  35629 MW;  513F5C710803800D CRC64;
     MIEVKHLKTL QALRNCGSLA AAAATLHQTQ SALSHQFSDL EQRLGFRLFV RKSQPLRFTP
     QGEILLQLAN QVLPQISQAL QACNEPQQTR LRIAIECHSC IQWLTPALEN FHKNWPQVEM
     DFKSGVTFDP QPALQQGELD LVMTSDILPR SGLHYSPMFD YEVRLVLAPD HPLAAKTRIT
     PEDLASETLL IYPVQRSRLD VWRHFLQPAG VSPSLKSVDN TLLLIQMVAA RMGIAALPHW
     VVESFERQGL VVTKTLGEGL WSRLYAAVRD GEQRQPVTEA FIRSARNHAC DHLPFVKSAE
     RPTYDAPTVR PGSPARL