ID   METX_METTH              Reviewed;         319 AA.
AC   O27848;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 128.
DE   RecName: Full=Probable acyltransferase {ECO:0000305};
DE            EC=2.3.1.- {ECO:0000305};
GN   Name=metX; OrderedLocusNames=MTH_1820;
OS   Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS   10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX   PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA   Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA   Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA   Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA   Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA   Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT   functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. MetX family.
CC       {ECO:0000305}.
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DR   EMBL; AE000666; AAB86286.1; -; Genomic_DNA.
DR   PIR; D69110; D69110.
DR   RefSeq; WP_010877422.1; NC_000916.1.
DR   AlphaFoldDB; O27848; -.
DR   SMR; O27848; -.
DR   STRING; 187420.MTH_1820; -.
DR   ESTHER; metth-metx; Homoserine_transacetylase.
DR   EnsemblBacteria; AAB86286; AAB86286; MTH_1820.
DR   GeneID; 1470905; -.
DR   KEGG; mth:MTH_1820; -.
DR   PATRIC; fig|187420.15.peg.1774; -.
DR   HOGENOM; CLU_028760_2_0_2; -.
DR   OMA; MGGMQTW; -.
DR   Proteomes; UP000005223; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   InterPro; IPR008220; HAT_MetX-like.
DR   PANTHER; PTHR32268; PTHR32268; 1.
DR   Pfam; PF00561; Abhydrolase_1; 1.
DR   PIRSF; PIRSF000443; Homoser_Ac_trans; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Cytoplasm; Reference proteome; Transferase.
FT   CHAIN           1..319
FT                   /note="Probable acyltransferase"
FT                   /id="PRO_0000155753"
FT   DOMAIN          46..301
FT                   /note="AB hydrolase-1"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        269
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   319 AA;  35688 MW;  46472BDE6F981F83 CRC64;
     MMEEIPASYF KIEEFQFESG EKIQEAPVEY RTTGKPSLDD MGVIDNAVIY IHGWSGDCSS
     VRRIAALTEP GGALENFFVI SISSLGSPGS ASPSTTAMGK DFPEYTILDM VNFQRQFLDE
     KFGIRKVRGV IGTSMGGFQA LQWAAEYPDE MEFLIPLVTS WQVRGINYAL FSYMNHLIEG
     DPEFRAGTRP ERALSLASML MYLHGLSREY YQGLENAELE SSMMDMGSEG ALMDPYDVIW
     RNRAAMKHDL SGKLESIRAR TLIFGVNQDR YFPPELDTIP MAQLIPKAEL VLFDSECGHL
     GVNEIGKYNE IIVSFIGGD