ID   11S1_MACIN              Reviewed;         102 AA.
AC   C0HLR7;
DT   02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT   02-JUN-2021, sequence version 1.
DT   03-AUG-2022, entry version 4.
DE   RecName: Full=11S globulin seed storage protein {ECO:0000303|Ref.1};
DE   AltName: Allergen=Mac i 2 {ECO:0000303|Ref.1};
DE   Flags: Fragments;
OS   Macadamia integrifolia (Macadamia nut).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Proteales; Proteaceae; Macadamia.
OX   NCBI_TaxID=60698 {ECO:0000303|Ref.1};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, AND
RP   ALLERGEN.
RA   Kabasser S., Bublin M.;
RT   "Identification of macadamia nut allergens and their role in IgE cross-
RT   reactivity among tree nuts.";
RL   Submitted (MAR-2020) to UniProtKB.
CC   -!- FUNCTION: Seed storage protein. {ECO:0000269|Ref.1}.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Recombinant protein
CC       binds to IgE in 75% of 8 patients allergic to Macadamia nut. Natural
CC       protein was also found to bind to IgE in 2 of the 8 patients allergic
CC       to Macadamia nut. {ECO:0000269|Ref.1}.
CC   -!- SIMILARITY: Belongs to the 11S seed storage protein (globulins) family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; C0HLR7; -.
DR   GO; GO:0019863; F:IgE binding; IDA:UniProtKB.
DR   GO; GO:0045735; F:nutrient reservoir activity; IEA:UniProtKB-KW.
DR   InterPro; IPR011051; RmlC_Cupin_sf.
DR   SUPFAM; SSF51182; SSF51182; 1.
PE   1: Evidence at protein level;
KW   Allergen; Direct protein sequencing; IgE-binding protein;
KW   Seed storage protein; Storage protein.
FT   CHAIN           1..102
FT                   /note="11S globulin seed storage protein"
FT                   /id="PRO_0000452985"
FT   NON_CONS        13..14
FT                   /evidence="ECO:0000303|Ref.1"
FT   NON_CONS        19..20
FT                   /evidence="ECO:0000303|Ref.1"
FT   NON_CONS        40..41
FT                   /evidence="ECO:0000303|Ref.1"
FT   NON_CONS        66..67
FT                   /evidence="ECO:0000303|Ref.1"
FT   NON_CONS        73..74
FT                   /evidence="ECO:0000303|Ref.1"
FT   NON_CONS        95..96
FT                   /evidence="ECO:0000303|Ref.1"
FT   NON_TER         1
FT                   /evidence="ECO:0000303|Ref.1"
FT   NON_TER         102
FT                   /evidence="ECO:0000303|Ref.1"
SQ   SEQUENCE   102 AA;  11492 MW;  BDC80404B7019AA4 CRC64;
     LSTLNTHNLP LLRLVYLERE DLVAVHVDDL NNQANQLDQK LDGGLLPQGH APHWLMNAHS
     LFYLTRLLVA QCRAPKGMLV VLPAGVAHWC LNDGKHYLDN PR