ID   ARLY_BIFLO              Reviewed;         490 AA.
AC   Q8G5F3;
DT   23-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Argininosuccinate lyase {ECO:0000255|HAMAP-Rule:MF_00006};
DE            Short=ASAL {ECO:0000255|HAMAP-Rule:MF_00006};
DE            EC=4.3.2.1 {ECO:0000255|HAMAP-Rule:MF_00006};
DE   AltName: Full=Arginosuccinase {ECO:0000255|HAMAP-Rule:MF_00006};
GN   Name=argH {ECO:0000255|HAMAP-Rule:MF_00006}; OrderedLocusNames=BL1057;
OS   Bifidobacterium longum (strain NCC 2705).
OC   Bacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae;
OC   Bifidobacterium.
OX   NCBI_TaxID=206672;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCC 2705;
RX   PubMed=12381787; DOI=10.1073/pnas.212527599;
RA   Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G.,
RA   Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.;
RT   "The genome sequence of Bifidobacterium longum reflects its adaptation to
RT   the human gastrointestinal tract.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-(N(omega)-L-arginino)succinate = fumarate + L-arginine;
CC         Xref=Rhea:RHEA:24020, ChEBI:CHEBI:29806, ChEBI:CHEBI:32682,
CC         ChEBI:CHEBI:57472; EC=4.3.2.1; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00006};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine
CC       from L-ornithine and carbamoyl phosphate: step 3/3. {ECO:0000255|HAMAP-
CC       Rule:MF_00006}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00006}.
CC   -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00006}.
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DR   EMBL; AE014295; AAN24865.1; -; Genomic_DNA.
DR   RefSeq; NP_696229.1; NC_004307.2.
DR   RefSeq; WP_007051162.1; NC_004307.2.
DR   AlphaFoldDB; Q8G5F3; -.
DR   SMR; Q8G5F3; -.
DR   STRING; 206672.BL1057; -.
DR   EnsemblBacteria; AAN24865; AAN24865; BL1057.
DR   GeneID; 66504807; -.
DR   KEGG; blo:BL1057; -.
DR   PATRIC; fig|206672.9.peg.763; -.
DR   HOGENOM; CLU_027272_2_2_11; -.
DR   OMA; KKNPDVF; -.
DR   PhylomeDB; Q8G5F3; -.
DR   UniPathway; UPA00068; UER00114.
DR   Proteomes; UP000000439; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004056; F:argininosuccinate lyase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
DR   CDD; cd01359; Argininosuccinate_lyase; 1.
DR   Gene3D; 1.10.275.10; -; 1.
DR   HAMAP; MF_00006; Arg_succ_lyase; 1.
DR   InterPro; IPR029419; Arg_succ_lyase_C.
DR   InterPro; IPR009049; Argininosuccinate_lyase.
DR   InterPro; IPR024083; Fumarase/histidase_N.
DR   InterPro; IPR020557; Fumarate_lyase_CS.
DR   InterPro; IPR000362; Fumarate_lyase_fam.
DR   InterPro; IPR022761; Fumarate_lyase_N.
DR   InterPro; IPR008948; L-Aspartase-like.
DR   PANTHER; PTHR43814; PTHR43814; 1.
DR   Pfam; PF14698; ASL_C2; 1.
DR   Pfam; PF00206; Lyase_1; 1.
DR   PRINTS; PR00149; FUMRATELYASE.
DR   SUPFAM; SSF48557; SSF48557; 1.
DR   TIGRFAMs; TIGR00838; argH; 1.
DR   PROSITE; PS00163; FUMARATE_LYASES; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Arginine biosynthesis; Cytoplasm; Lyase;
KW   Reference proteome.
FT   CHAIN           1..490
FT                   /note="Argininosuccinate lyase"
FT                   /id="PRO_0000137741"
SQ   SEQUENCE   490 AA;  53392 MW;  947BC541D5A7E78A CRC64;
     MTENNEHLAL WGGRFTSGPS PELARLSKST QFDWRLADDD IAGSRAHARA LGRAGLLTAD
     ELQRMEDALD TLQRHVDDGS FAPIEDDEDE ATALERGLID IAGDELGGKL RAGRSRNDQI
     ACLIRMWLRR HSRVIAGLLL DLVNALIEQS EKAGRTVMPG RTHMQHAQPV LLAHQLMAHA
     WPLIRDVQRL IDWDKRINAS PYGSGALAGN TLGLDPEAVA RELGFSRVTD NSIDGTAARD
     LVAEFAFVAA MTGVDISRLS EEIIIWNTQE FAFVKLDDGY STGSSIMPQK KNPDIAELAR
     GKSGRLIGDL TGLLATLKGL PTAYARDLQE DKEAVFDQVD TLEVLLPAFT GMVRTMHFDG
     DRLEEEAPTG FALATDIAEW LVKNGVPFRH AHELSGACVK LAEGRGQELW DLTDNDFIET
     FAAFLPADKA PGVREVLSSH GSVDSRNGKG GTAYGRVREQ IADAKAEVEE LKLFPASTSD
     GSAYKAPGTF