ID   MEU22_SCHPO             Reviewed;         574 AA.
AC   O60170; Q96WS2;
DT   14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 139.
DE   RecName: Full=Probable amino-acid permease meu22;
DE   AltName: Full=Meiotic expression up-regulated protein 22;
GN   Name=meu22; ORFNames=SPBC19F8.06c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 23-356.
RC   STRAIN=CD16-1;
RX   PubMed=11376151; DOI=10.1093/nar/29.11.2327;
RA   Watanabe T., Miyashita K., Saito T.T., Yoneki T., Kakihara Y.,
RA   Nabeshima K., Kishi Y.A., Shimoda C., Nojima H.;
RT   "Comprehensive isolation of meiosis-specific genes identifies novel
RT   proteins and unusual non-coding transcripts in Schizosaccharomyces pombe.";
RL   Nucleic Acids Res. 29:2327-2337(2001).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC       superfamily. {ECO:0000305}.
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DR   EMBL; CU329671; CAA19126.1; -; Genomic_DNA.
DR   EMBL; AB054306; BAB60873.1; -; mRNA.
DR   PIR; T39829; T39829.
DR   RefSeq; NP_596348.1; NM_001022268.2.
DR   AlphaFoldDB; O60170; -.
DR   SMR; O60170; -.
DR   BioGRID; 277298; 21.
DR   STRING; 4896.SPBC19F8.06c.1; -.
DR   TCDB; 2.A.3.10.28; the amino acid-polyamine-organocation (apc) family.
DR   PaxDb; O60170; -.
DR   EnsemblFungi; SPBC19F8.06c.1; SPBC19F8.06c.1:pep; SPBC19F8.06c.
DR   GeneID; 2540779; -.
DR   KEGG; spo:SPBC19F8.06c; -.
DR   PomBase; SPBC19F8.06c; meu22.
DR   VEuPathDB; FungiDB:SPBC19F8.06c; -.
DR   eggNOG; KOG1286; Eukaryota.
DR   HOGENOM; CLU_007946_12_0_1; -.
DR   InParanoid; O60170; -.
DR   OMA; NYALFWV; -.
DR   PhylomeDB; O60170; -.
DR   PRO; PR:O60170; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0016021; C:integral component of membrane; ISM:PomBase.
DR   GO; GO:0015171; F:amino acid transmembrane transporter activity; ISM:PomBase.
DR   GO; GO:0003333; P:amino acid transmembrane transport; ISM:PomBase.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR004841; AA-permease/SLC12A_dom.
DR   InterPro; IPR004840; Amoino_acid_permease_CS.
DR   Pfam; PF00324; AA_permease; 1.
DR   PROSITE; PS00218; AMINO_ACID_PERMEASE_1; 1.
PE   2: Evidence at transcript level;
KW   Amino-acid transport; Meiosis; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..574
FT                   /note="Probable amino-acid permease meu22"
FT                   /id="PRO_0000054168"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        291..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        391..411
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        412..432
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        470..490
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        498..518
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   574 AA;  62691 MW;  113E0510984F3199 CRC64;
     MLSKFYEDID SKLENAMLSQ IESSTITCDG KSLNTLPTPK QEDVEFGVPL QPEDTQDLQR
     KLKPRHMQMI AIGGCVGTGL FVGSGNALAD GGPASILIAF AVIGTYVLFT TSALAELSAI
     YPVSGSFYTY FSKFIDPAWG FAVGIQYWLS FAVTVPLELT VAPLIINFWN ASGPVSIWIS
     VFYVIIIAIN IWGTEGYGEV EFFLSIMKVI SVIGFVILSI IIAAGGVPTD DRGVIGVSYW
     KQPLVFNNGF KGLCAVSVIA IFSLSGTELV GLAASEAKNP QKTVPAAVKQ IFWRIFLFYI
     VALFMLTLVV PSDLPGLRTS DNSNVLISPF VIAIQLANIR ALPSIMNVVI LLSTLSVGNS
     ASYAASRALF ALAKNGYAPK IFNKTNKRGH PIYAIAVTLL FGSIAYFTEA GVGGALFGWL
     LSICGLSTTF IWGSICLAHI QFRRAWKIQN RKLEDLPYRS IFGVYGSIYG VAMTILALIA
     QFYVAVFPIG KKPNPVDFFQ AYMAAPILII SFVAWKFFRR TSFVRIEKID LSEGAHGEQK
     QNLEPVINIP VEEIDFPMKV ATKESMKNVE KNAL