ID   MEX2_JACME              Reviewed;         215 AA.
AC   P84347;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 40.
DE   RecName: Full=Chymomexicain;
DE            EC=3.4.22.-;
OS   Jacaratia mexicana (Wild papaya) (Pileus mexicanus).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Caricaceae; Jacaratia.
OX   NCBI_TaxID=309130;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, AND FUNCTION.
RA   Lian Z.;
RT   "Modification of calcite crystal morphology by designed phosphopeptides and
RT   primary structures and substrate specificities of the cysteine proteases
RT   mexicain and chymomexicain.";
RL   Thesis (1999), Boston University, United States.
CC   -!- FUNCTION: Cysteine protease. {ECO:0000269|Ref.1}.
CC   -!- SIMILARITY: Belongs to the peptidase C1 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU10088, ECO:0000255|PROSITE-ProRule:PRU10089}.
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DR   AlphaFoldDB; P84347; -.
DR   SMR; P84347; -.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd02248; Peptidase_C1A; 1.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR000169; Pept_cys_AS.
DR   InterPro; IPR025660; Pept_his_AS.
DR   InterPro; IPR000668; Peptidase_C1A_C.
DR   InterPro; IPR039417; Peptidase_C1A_papain-like.
DR   Pfam; PF00112; Peptidase_C1; 1.
DR   PRINTS; PR00705; PAPAIN.
DR   SMART; SM00645; Pept_C1; 1.
DR   SUPFAM; SSF54001; SSF54001; 1.
DR   PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR   PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hydrolase; Protease;
KW   Thiol protease.
FT   CHAIN           1..215
FT                   /note="Chymomexicain"
FT                   /id="PRO_0000050557"
FT   ACT_SITE        25
FT                   /evidence="ECO:0000250|UniProtKB:P14080"
FT   ACT_SITE        160
FT                   /evidence="ECO:0000250|UniProtKB:P14080"
FT   ACT_SITE        176
FT                   /evidence="ECO:0000250|UniProtKB:P14080"
FT   DISULFID        22..63
FT                   /evidence="ECO:0000250|UniProtKB:P14080"
FT   DISULFID        56..96
FT                   /evidence="ECO:0000250|UniProtKB:P14080"
FT   DISULFID        154..201
FT                   /evidence="ECO:0000250|UniProtKB:P14080"
SQ   SEQUENCE   215 AA;  23666 MW;  0B4603A661CCE735 CRC64;
     YPESIDWRDK GAVTPVKNQN PCGSCWAFST VATVEGINKI RTGKLISLSE QELLDCDRRS
     HGCKGGYQTG SIQYVADNGG VHTEKEYPYE KKQGKCRAKE KKGTKVQITG YKRVPANDEI
     SLIQGIGNQP VSVLHESKGR AFQLYKGGIF NGPCGYKNDH AVTAIGYGKA QLLDKNSWGP
     NWGEKGYIKI KRASGKSEGT CGVYKSSYFP IKGYR