MEX3A_HUMAN
ID MEX3A_HUMAN Reviewed; 520 AA.
AC A1L020;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=RNA-binding protein MEX3A;
DE AltName: Full=RING finger and KH domain-containing protein 4;
GN Name=MEX3A; Synonyms=RKHD4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, PHOSPHORYLATION, AND
RP TISSUE SPECIFICITY.
RX PubMed=17267406; DOI=10.1093/nar/gkm016;
RA Buchet-Poyau K., Courchet J., Le Hir H., Seraphin B., Scoazec J.-Y.,
RA Duret L., Domon-Dell C., Freund J.-N., Billaud M.;
RT "Identification and characterization of human Mex-3 proteins, a novel
RT family of evolutionarily conserved RNA-binding proteins differentially
RT localized to processing bodies.";
RL Nucleic Acids Res. 35:1289-1300(2007).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-338 AND SER-462, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: RNA binding protein, may be involved in post-transcriptional
CC regulatory mechanisms.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17267406}. Nucleus
CC {ECO:0000269|PubMed:17267406}. Cytoplasm, P-body
CC {ECO:0000269|PubMed:17267406}. Note=Predominantly expressed in the
CC cytoplasm and shuttles between the cytoplasm and the nucleus through
CC the CRM1 export pathway.
CC -!- TISSUE SPECIFICITY: Highest levels found in fetal brain and testis.
CC Detected also in thymus, salivary gland and uterus.
CC {ECO:0000269|PubMed:17267406}.
CC -!- DOMAIN: Binds RNA through its KH domains. {ECO:0000250}.
CC -!- PTM: Phosphorylated. {ECO:0000269|PubMed:17267406}.
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DR EMBL; AY950677; AAY34145.1; -; mRNA.
DR CCDS; CCDS53377.1; -.
DR RefSeq; NP_001087194.1; NM_001093725.1.
DR AlphaFoldDB; A1L020; -.
DR SMR; A1L020; -.
DR BioGRID; 124933; 45.
DR IntAct; A1L020; 4.
DR STRING; 9606.ENSP00000432845; -.
DR GlyGen; A1L020; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; A1L020; -.
DR PhosphoSitePlus; A1L020; -.
DR BioMuta; MEX3A; -.
DR EPD; A1L020; -.
DR jPOST; A1L020; -.
DR MassIVE; A1L020; -.
DR MaxQB; A1L020; -.
DR PaxDb; A1L020; -.
DR PeptideAtlas; A1L020; -.
DR PRIDE; A1L020; -.
DR ProteomicsDB; 128; -.
DR Antibodypedia; 56937; 62 antibodies from 22 providers.
DR DNASU; 92312; -.
DR Ensembl; ENST00000532414.3; ENSP00000432845.1; ENSG00000254726.3.
DR GeneID; 92312; -.
DR KEGG; hsa:92312; -.
DR MANE-Select; ENST00000532414.3; ENSP00000432845.1; NM_001093725.2; NP_001087194.1.
DR UCSC; uc001fnd.4; human.
DR CTD; 92312; -.
DR DisGeNET; 92312; -.
DR GeneCards; MEX3A; -.
DR HGNC; HGNC:33482; MEX3A.
DR HPA; ENSG00000254726; Tissue enhanced (endometrium, ovary).
DR MIM; 611007; gene.
DR neXtProt; NX_A1L020; -.
DR OpenTargets; ENSG00000254726; -.
DR PharmGKB; PA162395812; -.
DR VEuPathDB; HostDB:ENSG00000254726; -.
DR eggNOG; KOG2113; Eukaryota.
DR GeneTree; ENSGT00940000161732; -.
DR HOGENOM; CLU_025598_0_0_1; -.
DR InParanoid; A1L020; -.
DR OMA; WAGQENT; -.
DR OrthoDB; 814376at2759; -.
DR PhylomeDB; A1L020; -.
DR TreeFam; TF315107; -.
DR PathwayCommons; A1L020; -.
DR SignaLink; A1L020; -.
DR BioGRID-ORCS; 92312; 105 hits in 1121 CRISPR screens.
DR ChiTaRS; MEX3A; human.
DR GenomeRNAi; 92312; -.
DR Pharos; A1L020; Tbio.
DR PRO; PR:A1L020; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; A1L020; protein.
DR Bgee; ENSG00000254726; Expressed in ganglionic eminence and 164 other tissues.
DR Genevisible; A1L020; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000932; C:P-body; IDA:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IDA:UniProtKB.
DR Gene3D; 3.30.1370.10; -; 2.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF00013; KH_1; 2.
DR SMART; SM00322; KH; 2.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF54791; SSF54791; 2.
DR PROSITE; PS50084; KH_TYPE_1; 2.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Metal-binding; Nucleus; Phosphoprotein; Reference proteome;
KW Repeat; RNA-binding; Zinc; Zinc-finger.
FT CHAIN 1..520
FT /note="RNA-binding protein MEX3A"
FT /id="PRO_0000281013"
FT DOMAIN 132..193
FT /note="KH 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT DOMAIN 223..284
FT /note="KH 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT ZN_FING 469..509
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT REGION 49..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 412..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..103
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 338
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 462
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
SQ SEQUENCE 520 AA; 54173 MW; 78C5A5253B2673BE CRC64;
MPSLVVSGIM ERNGGFGELG CFGGSAKDRG LLEDERALQL ALDQLCLLGL GEPPAPTAGE
DGGGGGGGAP AQPAAPPQPA PPPPPAAPPA APTAAPAAQT PQPPTAPKGA SDAKLCALYK
EAELRLKGSS NTTECVPVPT SEHVAEIVGR QGCKIKALRA KTNTYIKTPV RGEEPVFMVT
GRREDVATAR REIISAAEHF SMIRASRNKS GAAFGVAPAL PGQVTIRVRV PYRVVGLVVG
PKGATIKRIQ QQTNTYIITP SRDRDPVFEI TGAPGNVERA REEIETHIAV RTGKILEYNN
ENDFLAGSPD AAIDSRYSDA WRVHQPGCKP LSTFRQNSLG CIGECGVDSG FEAPRLGEQG
GDFGYGGYLF PGYGVGKQDV YYGVAETSPP LWAGQENATP TSVLFSSASS SSSSSAKARA
GPPGAHRSPA TSAGPELAGL PRRPPGEPLQ GFSKLGGGGL RSPGGGRDCM VCFESEVTAA
LVPCGHNLFC MECAVRICER TDPECPVCHI TATQAIRIFS
