ID   MEX3B_XENLA             Reviewed;         507 AA.
AC   A1L3F4;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=RNA-binding protein MEX3B;
DE   AltName: Full=RING finger and KH domain-containing protein 3;
GN   Name=mex3b; Synonyms=rkhd3;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RNA-binding protein. May be involved in post-transcriptional
CC       regulatory mechanisms (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Cytoplasmic granule {ECO:0000250}. Cytoplasm, P-body {ECO:0000250}.
CC       Note=Predominantly expressed in the cytoplasm and shuttles between the
CC       cytoplasm and the nucleus through the CRM1 export pathway.
CC       {ECO:0000250}.
CC   -!- DOMAIN: Binds RNA through its KH domains. {ECO:0000250}.
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DR   EMBL; BC130069; AAI30070.1; -; mRNA.
DR   RefSeq; NP_001091216.1; NM_001097747.1.
DR   AlphaFoldDB; A1L3F4; -.
DR   SMR; A1L3F4; -.
DR   GeneID; 100036990; -.
DR   KEGG; xla:100036990; -.
DR   CTD; 100036990; -.
DR   Xenbase; XB-GENE-5857382; mex3b.S.
DR   OrthoDB; 814376at2759; -.
DR   Proteomes; UP000186698; Chromosome 3S.
DR   Bgee; 100036990; Expressed in internal ear and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1370.10; -; 2.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR004088; KH_dom_type_1.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF00013; KH_1; 2.
DR   SMART; SM00322; KH; 2.
DR   SMART; SM00184; RING; 1.
DR   SUPFAM; SSF54791; SSF54791; 2.
DR   PROSITE; PS50084; KH_TYPE_1; 2.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Metal-binding; Nucleus; Reference proteome; Repeat; RNA-binding;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..507
FT                   /note="RNA-binding protein MEX3B"
FT                   /id="PRO_0000281014"
FT   DOMAIN          59..120
FT                   /note="KH 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT   DOMAIN          155..216
FT                   /note="KH 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
FT   ZN_FING         456..496
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          256..279
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          426..450
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   507 AA;  54164 MW;  0762B0CC51640EA5 CRC64;
     MPSSLFADME RNGSGGGGGE TLDDQRALQI ALDQLSLLGL DNDESAMYDN EPRKKSINMT
     ECVQVPSSEH VAEIVGRQGC KIKALRAKTN TYIKTPVRGE EPVFVVTGRK EDVALARREI
     ISAAEHFSMI RASRNKNAAA LNGGSVPAPP NLPGQTTIQV RVPYRVVGLV VGPKGATIKR
     IQQQTHTYIV TPSRDKEPVF EVTGMPENVD RAREEIEAHI AVRTGGLIEV ADENDFHANG
     TDVGFDLHGS LWSKSNQSSG SRKALSNYRN DSSSSLGSAS TDSYFGGTRM ADYSPPSPDL
     SYTNNNNNNN GNGYVYSTGI SPDCTDLTFE SGFDPAPAPP PSAYTWSQLE RSTGSAPYHN
     NANGILLNQR RLNGVGCTTA PRLSPPLHTC NGLSEHPLAR RVRSDPGGGL SYSAYSNMAC
     DSSSSSSSSS SSSSSSSSSS SSSSSSGMRR KGSRECSICF ESEVIAALVP CGHNLFCMEC
     ANRICEKNQP QCPVCHAGVT QAIRIFS