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MEXR_PSEAE
ID   MEXR_PSEAE              Reviewed;         147 AA.
AC   P52003; Q5EEX3; Q5EEX4; Q5EEX5; Q83UE4;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 136.
DE   RecName: Full=Multidrug resistance operon repressor;
GN   Name=mexR; OrderedLocusNames=PA0424;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT OCR1.
RC   STRAIN=PAO;
RX   PubMed=8878574; DOI=10.1128/aac.40.9.2021;
RA   Poole K., Tetro K., Zhao Q., Neshat S., Heinrichs D.E., Bianco N.;
RT   "Expression of the multidrug resistance operon mexA-mexB-oprM in
RT   Pseudomonas aeruginosa: mexR encodes a regulator of operon expression.";
RL   Antimicrob. Agents Chemother. 40:2021-2028(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS.
RC   STRAIN=55699, 58823, 65629, and GRR;
RA   Ho S.E., Navaratnam P.;
RT   "Mutation in MexAB-OprM regulator gene, MexR contribute to the carbapenem
RT   resistance in Pseudomonas aeruginosa.";
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS.
RC   STRAIN=PA36, PA41, and PA48;
RA   Yi M., Wang P., Liu Y., Huang H.;
RT   "Mutation in MexAB-OprM regulator gene, MexR contributes to the multidrug
RT   resistance in Pseudomonas aeruginosa.";
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
RN   [5]
RP   X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS), AND SUBUNIT.
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=12034710; DOI=10.1074/jbc.m111381200;
RA   Lim D., Poole K., Strynadka N.C.J.;
RT   "Crystal structure of the MexR repressor of the mexRAB-oprM multidrug
RT   efflux operon of Pseudomonas aeruginosa.";
RL   J. Biol. Chem. 277:29253-29259(2002).
CC   -!- FUNCTION: Repressor of the mexAB-oprM multidrug resistance operon. Also
CC       represses its own expression. Many variants lead to increased
CC       expression of the mexAB-oprM operon.
CC   -!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:12034710}.
CC   -!- INTERACTION:
CC       P52003; Q9HXS2: armR; NbExp=2; IntAct=EBI-6400193, EBI-6400203;
CC       P52003; P52003: mexR; NbExp=2; IntAct=EBI-6400193, EBI-6400193;
CC       P52003; Q8GQ91: armR; Xeno; NbExp=5; IntAct=EBI-6400193, EBI-15730301;
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DR   EMBL; U23763; AAA69479.1; -; Genomic_DNA.
DR   EMBL; AY190292; AAO40255.1; -; Genomic_DNA.
DR   EMBL; AY190294; AAO40257.1; -; Genomic_DNA.
DR   EMBL; AY190293; AAO40256.1; -; Genomic_DNA.
DR   EMBL; AY190295; AAO40258.1; -; Genomic_DNA.
DR   EMBL; AY899299; AAW82614.1; -; Genomic_DNA.
DR   EMBL; AY899300; AAW82615.1; -; Genomic_DNA.
DR   EMBL; AY899301; AAW82616.1; -; Genomic_DNA.
DR   EMBL; AE004091; AAG03813.1; -; Genomic_DNA.
DR   PIR; C83593; C83593.
DR   RefSeq; NP_249115.1; NC_002516.2.
DR   RefSeq; WP_003114897.1; NZ_QZGE01000016.1.
DR   PDB; 1LNW; X-ray; 2.10 A; A/B/C/D/E/F/G/H=1-147.
DR   PDB; 3ECH; X-ray; 1.80 A; A/B=1-142.
DR   PDB; 3MEX; X-ray; 2.10 A; A/B=1-142.
DR   PDB; 4ZZL; X-ray; 2.19 A; A/B=5-139.
DR   PDBsum; 1LNW; -.
DR   PDBsum; 3ECH; -.
DR   PDBsum; 3MEX; -.
DR   PDBsum; 4ZZL; -.
DR   AlphaFoldDB; P52003; -.
DR   SMR; P52003; -.
DR   DIP; DIP-46302N; -.
DR   IntAct; P52003; 2.
DR   MINT; P52003; -.
DR   STRING; 287.DR97_3392; -.
DR   PaxDb; P52003; -.
DR   PRIDE; P52003; -.
DR   DNASU; 877857; -.
DR   EnsemblBacteria; AAG03813; AAG03813; PA0424.
DR   GeneID; 877857; -.
DR   KEGG; pae:PA0424; -.
DR   PATRIC; fig|208964.12.peg.446; -.
DR   PseudoCAP; PA0424; -.
DR   HOGENOM; CLU_083287_18_6_6; -.
DR   InParanoid; P52003; -.
DR   OMA; GRQMCRD; -.
DR   PhylomeDB; P52003; -.
DR   BioCyc; PAER208964:G1FZ6-428-MON; -.
DR   EvolutionaryTrace; P52003; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0032993; C:protein-DNA complex; IPI:CollecTF.
DR   GO; GO:0001217; F:DNA-binding transcription repressor activity; IPI:CollecTF.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:CollecTF.
DR   GO; GO:0050709; P:negative regulation of protein secretion; IMP:PseudoCAP.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:PseudoCAP.
DR   GO; GO:0034763; P:negative regulation of transmembrane transport; IMP:PseudoCAP.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01047; MarR; 1.
DR   PRINTS; PR00598; HTHMARR.
DR   SMART; SM00347; HTH_MARR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50995; HTH_MARR_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..147
FT                   /note="Multidrug resistance operon repressor"
FT                   /id="PRO_0000054365"
FT   DOMAIN          6..140
FT                   /note="HTH marR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00345"
FT   VARIANT         69
FT                   /note="T -> A (in strain: PA48)"
FT   VARIANT         70
FT                   /note="R -> W (in strain: OCR1; leads to increased
FT                   expression of mexAB-oprM)"
FT   VARIANT         95
FT                   /note="L -> F (in strain: PA41)"
FT   VARIANT         126
FT                   /note="V -> E (in strain: 58823, 65629, 55699 and GRR)"
FT   VARIANT         130
FT                   /note="T -> S (in strain: PA36)"
FT   HELIX           9..30
FT                   /evidence="ECO:0007829|PDB:3ECH"
FT   HELIX           37..48
FT                   /evidence="ECO:0007829|PDB:3ECH"
FT   TURN            49..51
FT                   /evidence="ECO:0007829|PDB:3ECH"
FT   HELIX           54..61
FT                   /evidence="ECO:0007829|PDB:3ECH"
FT   HELIX           67..77
FT                   /evidence="ECO:0007829|PDB:3ECH"
FT   STRAND          80..82
FT                   /evidence="ECO:0007829|PDB:3ECH"
FT   STRAND          87..97
FT                   /evidence="ECO:0007829|PDB:1LNW"
FT   HELIX           99..120
FT                   /evidence="ECO:0007829|PDB:3ECH"
FT   HELIX           125..140
FT                   /evidence="ECO:0007829|PDB:3ECH"
SQ   SEQUENCE   147 AA;  16965 MW;  59F5146394BE89DD CRC64;
     MNYPVNPDLM PALMAVFQHV RTRIQSELDC QRLDLTPPDV HVLKLIDEQR GLNLQDLGRQ
     MCRDKALITR KIRELEGRNL VRRERNPSDQ RSFQLFLTDE GLAIHQHAEA IMSRVHDELF
     APLTPVEQAT LVHLLDQCLA AQPLEDI
 
 
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