ID   MF127_ASPFN             Reviewed;         529 AA.
AC   B8MYS7;
DT   11-MAY-2016, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=MFS glucose transporter mfs1 {ECO:0000305};
DE   AltName: Full=Asparasone A synthesis protein mfs1 {ECO:0000305};
GN   Name=mfs1 {ECO:0000303|PubMed:24412484}; ORFNames=AFLA_082160;
OS   Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357
OS   / JCM 12722 / SRRC 167).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=332952;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC
RC   167;
RX   PubMed=25883274; DOI=10.1128/genomea.00168-15;
RA   Nierman W.C., Yu J., Fedorova-Abrams N.D., Losada L., Cleveland T.E.,
RA   Bhatnagar D., Bennett J.W., Dean R., Payne G.A.;
RT   "Genome sequence of Aspergillus flavus NRRL 3357, a strain that causes
RT   aflatoxin contamination of food and feed.";
RL   Genome Announc. 3:E0016815-E0016815(2015).
RN   [2]
RP   INDUCTION.
RX   PubMed=24412484; DOI=10.1016/j.fgb.2014.01.001;
RA   Cary J.W., Harris-Coward P.Y., Ehrlich K.C., Di Mavungu J.D.,
RA   Malysheva S.V., De Saeger S., Dowd P.F., Shantappa S., Martens S.L.,
RA   Calvo A.M.;
RT   "Functional characterization of a veA-dependent polyketide synthase gene in
RT   Aspergillus flavus necessary for the synthesis of asparasone, a sclerotium-
RT   specific pigment.";
RL   Fungal Genet. Biol. 64:25-35(2014).
CC   -!- FUNCTION: Probable MFS glucose transporter; part of the gene cluster 27
CC       that mediates the biosynthesis of asparasone A, a sclerotium-specific
CC       anthraquinone pigment important for sclerotial survival
CC       (PubMed:24412484). {ECO:0000269|PubMed:24412484}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- INDUCTION: Expression is induced by the developmental and secondary
CC       metabolism regulator veA (PubMed:24412484).
CC       {ECO:0000269|PubMed:24412484}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC       transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR   EMBL; EQ963472; EED57519.1; -; Genomic_DNA.
DR   RefSeq; XP_002373131.1; XM_002373090.1.
DR   AlphaFoldDB; B8MYS7; -.
DR   SMR; B8MYS7; -.
DR   EnsemblFungi; EED57519; EED57519; AFLA_082160.
DR   VEuPathDB; FungiDB:AFLA_082160; -.
DR   eggNOG; KOG0254; Eukaryota.
DR   HOGENOM; CLU_001265_30_12_1; -.
DR   OMA; WNCILAF; -.
DR   Proteomes; UP000001875; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR005828; MFS_sugar_transport-like.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR003663; Sugar/inositol_transpt.
DR   InterPro; IPR005829; Sugar_transporter_CS.
DR   Pfam; PF00083; Sugar_tr; 1.
DR   PRINTS; PR00171; SUGRTRNSPORT.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00879; SP; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..529
FT                   /note="MFS glucose transporter mfs1"
FT                   /id="PRO_0000436130"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        52..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        109..129
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        301..321
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        330..350
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        375..395
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        415..439
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        446..464
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   529 AA;  58332 MW;  C44014F112CCB91A CRC64;
     MKKIYNVYFL CGFATLGGGL FGFDISSMSG VLGTAAYTNY FQVGSGQYKQ GSITCAMPFG
     SLVGALCSSF IADRYSRVRA IQFSSILWII GSIFMCASNG IPLLVVGRVI AGGCVGIASA
     MVPVYQAEIA PKEIRGRVIS LQQWAITWGI LIQYFIQYGA SNIDGGPNNP TQSTAAFRIP
     WGIQIVPGVI LFFGMFLFPK SPRWLASKDR WEEALQVLSK LHGQGDVNHP KVLAEYKEIQ
     EALALEREQS ATGFQELIKP RIFKRVILGM SLQMWSQLCG MNVMMYYIVY IMQSTGAGSP
     LLTASIQYIL NTALTLPAII YLDKFGRRPA ILIGFFLQAI FLYLEGGLQG GFGAPNPHTD
     PKLDAISWTV ADHPAVGKAI IALSYLFVCS FATTIGPTSW TYPAEIYPAK VRAKAVSLAT
     ASNWIWNCLL ALFVPPLLWS INWKMYMIFA AFNTAAFIHM FLTAPETKGY TLEEMDDVFD
     SGLPAWRKLE RKSRMEELEK EIIEGNLKIT PAHEATGVSA THVTPEKQV