MF13A_HUMAN
ID MF13A_HUMAN Reviewed; 517 AA.
AC Q14CX5; Q6NWM8; Q6NWM9; Q6PEZ7; Q9H679;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 22-AUG-2006, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Transmembrane protein 180 {ECO:0000312|HGNC:HGNC:26196};
DE AltName: Full=Major facilitator superfamily domain-containing 13A {ECO:0000312|HGNC:HGNC:26196};
GN Name=MFSD13A {ECO:0000312|HGNC:HGNC:26196};
GN Synonyms=C10orf77, TMEM180 {ECO:0000312|HGNC:HGNC:26196};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 193-517.
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- INTERACTION:
CC Q14CX5; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-12120958, EBI-3867333;
CC Q14CX5; Q8IUC2: KRTAP8-1; NbExp=3; IntAct=EBI-12120958, EBI-10261141;
CC Q14CX5; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-12120958, EBI-22310682;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH67530.2; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAH67531.2; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAB15385.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL121928; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC057787; AAH57787.2; -; mRNA.
DR EMBL; BC067530; AAH67530.2; ALT_INIT; mRNA.
DR EMBL; BC067531; AAH67531.2; ALT_INIT; mRNA.
DR EMBL; BC113589; AAI13590.1; -; mRNA.
DR EMBL; AK026182; BAB15385.1; ALT_INIT; mRNA.
DR CCDS; CCDS7535.1; -.
DR RefSeq; NP_079065.2; NM_024789.3.
DR RefSeq; XP_006718036.1; XM_006717973.3.
DR RefSeq; XP_006718037.1; XM_006717974.3.
DR RefSeq; XP_011538462.1; XM_011540160.2.
DR RefSeq; XP_011538465.1; XM_011540163.2.
DR RefSeq; XP_016872143.1; XM_017016654.1.
DR RefSeq; XP_016872144.1; XM_017016655.1.
DR RefSeq; XP_016872145.1; XM_017016656.1.
DR AlphaFoldDB; Q14CX5; -.
DR SMR; Q14CX5; -.
DR BioGRID; 122938; 9.
DR IntAct; Q14CX5; 4.
DR STRING; 9606.ENSP00000238936; -.
DR TCDB; 2.A.2.3.10; the glycoside-pentoside-hexuronide (gph):cation symporter family.
DR TCDB; 2.A.2.3.14; the glycoside-pentoside-hexuronide (gph):cation symporter family.
DR iPTMnet; Q14CX5; -.
DR PhosphoSitePlus; Q14CX5; -.
DR BioMuta; MFSD13A; -.
DR DMDM; 122012175; -.
DR MassIVE; Q14CX5; -.
DR PaxDb; Q14CX5; -.
DR PeptideAtlas; Q14CX5; -.
DR PRIDE; Q14CX5; -.
DR ProteomicsDB; 60334; -.
DR ABCD; Q14CX5; 11 sequenced antibodies.
DR Antibodypedia; 18048; 27 antibodies from 12 providers.
DR DNASU; 79847; -.
DR Ensembl; ENST00000238936.8; ENSP00000238936.3; ENSG00000138111.14.
DR GeneID; 79847; -.
DR KEGG; hsa:79847; -.
DR MANE-Select; ENST00000238936.8; ENSP00000238936.3; NM_024789.4; NP_079065.2.
DR UCSC; uc001kvt.4; human.
DR CTD; 79847; -.
DR DisGeNET; 79847; -.
DR GeneCards; MFSD13A; -.
DR HGNC; HGNC:26196; MFSD13A.
DR HPA; ENSG00000138111; Low tissue specificity.
DR neXtProt; NX_Q14CX5; -.
DR OpenTargets; ENSG00000138111; -.
DR PharmGKB; PA162406011; -.
DR VEuPathDB; HostDB:ENSG00000138111; -.
DR eggNOG; ENOG502QSW5; Eukaryota.
DR GeneTree; ENSGT00940000160317; -.
DR HOGENOM; CLU_034985_0_0_1; -.
DR InParanoid; Q14CX5; -.
DR OMA; FVCMNLV; -.
DR OrthoDB; 1041483at2759; -.
DR PhylomeDB; Q14CX5; -.
DR TreeFam; TF313122; -.
DR PathwayCommons; Q14CX5; -.
DR SignaLink; Q14CX5; -.
DR BioGRID-ORCS; 79847; 15 hits in 1073 CRISPR screens.
DR ChiTaRS; MFSD13A; human.
DR GenomeRNAi; 79847; -.
DR Pharos; Q14CX5; Tdark.
DR PRO; PR:Q14CX5; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q14CX5; protein.
DR Bgee; ENSG00000138111; Expressed in right hemisphere of cerebellum and 100 other tissues.
DR ExpressionAtlas; Q14CX5; baseline and differential.
DR Genevisible; Q14CX5; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR040035; TMEM180.
DR PANTHER; PTHR28658; PTHR28658; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..517
FT /note="Transmembrane protein 180"
FT /id="PRO_0000256224"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..123
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..288
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 306..326
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 332..354
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 401..421
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 466..486
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 371
FT /note="T -> P (in Ref. 2; AAH67531)"
FT /evidence="ECO:0000305"
FT CONFLICT 489
FT /note="F -> S (in Ref. 2; AAH57787)"
FT /evidence="ECO:0000305"
FT CONFLICT 505
FT /note="N -> S (in Ref. 2; AAH67530/AAH67531)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 517 AA; 57381 MW; 50CC5110F967D588 CRC64;
MGLGQPQAWL LGLPTAVVYG SLALFTTILH NVFLLYYVDT FVSVYKINKM AFWVGETVFL
LWNSLNDPLF GWLSDRQFLS SQPRSGAGLS SRAVVLARVQ ALGWHGPLLA LSFLAFWVPW
APAGLQFLLC LCLYDGFLTL VDLHHHALLA DLALSAHDRT HLNFYCSLFS AAGSLSVFAS
YAFWNKEDFS SFRAFCVTLA VSSGLGFLGA TQLLRRRVEA ARKDPGCSGL VVDSGLCGEE
LLVGSEEADS ITLGRYLRQL ARHRNFLWFV SMDLVQVFHC HFNSNFFPLF LEHLLSDHIS
LSTGSILLGL SYVAPHLNNL YFLSLCRRWG VYAVVRGLFL LKLGLSLLML LAGPDHLSLL
CLFIASNRVF TEGTCKLLTL VVTDLVDEDL VLNHRKQAAS ALLFGMVALV TKPGQTFAPL
LGTWLLCFYT GHDLFQQSLI TPVGSAHPWP EPPAPAPAQA PTLRQGCFYL LVLVPITCAL
LQLFTWSQFT LHGRRLHMVK AQRQNLSQAQ TLDVKMV