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MF13A_HUMAN
ID   MF13A_HUMAN             Reviewed;         517 AA.
AC   Q14CX5; Q6NWM8; Q6NWM9; Q6PEZ7; Q9H679;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Transmembrane protein 180 {ECO:0000312|HGNC:HGNC:26196};
DE   AltName: Full=Major facilitator superfamily domain-containing 13A {ECO:0000312|HGNC:HGNC:26196};
GN   Name=MFSD13A {ECO:0000312|HGNC:HGNC:26196};
GN   Synonyms=C10orf77, TMEM180 {ECO:0000312|HGNC:HGNC:26196};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA   Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA   Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA   Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA   Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA   Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA   Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA   Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA   McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA   Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA   Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA   Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA   Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA   Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA   Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA   Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 193-517.
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
CC   -!- INTERACTION:
CC       Q14CX5; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-12120958, EBI-3867333;
CC       Q14CX5; Q8IUC2: KRTAP8-1; NbExp=3; IntAct=EBI-12120958, EBI-10261141;
CC       Q14CX5; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-12120958, EBI-22310682;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH67530.2; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAH67531.2; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAB15385.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AL121928; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC057787; AAH57787.2; -; mRNA.
DR   EMBL; BC067530; AAH67530.2; ALT_INIT; mRNA.
DR   EMBL; BC067531; AAH67531.2; ALT_INIT; mRNA.
DR   EMBL; BC113589; AAI13590.1; -; mRNA.
DR   EMBL; AK026182; BAB15385.1; ALT_INIT; mRNA.
DR   CCDS; CCDS7535.1; -.
DR   RefSeq; NP_079065.2; NM_024789.3.
DR   RefSeq; XP_006718036.1; XM_006717973.3.
DR   RefSeq; XP_006718037.1; XM_006717974.3.
DR   RefSeq; XP_011538462.1; XM_011540160.2.
DR   RefSeq; XP_011538465.1; XM_011540163.2.
DR   RefSeq; XP_016872143.1; XM_017016654.1.
DR   RefSeq; XP_016872144.1; XM_017016655.1.
DR   RefSeq; XP_016872145.1; XM_017016656.1.
DR   AlphaFoldDB; Q14CX5; -.
DR   SMR; Q14CX5; -.
DR   BioGRID; 122938; 9.
DR   IntAct; Q14CX5; 4.
DR   STRING; 9606.ENSP00000238936; -.
DR   TCDB; 2.A.2.3.10; the glycoside-pentoside-hexuronide (gph):cation symporter family.
DR   TCDB; 2.A.2.3.14; the glycoside-pentoside-hexuronide (gph):cation symporter family.
DR   iPTMnet; Q14CX5; -.
DR   PhosphoSitePlus; Q14CX5; -.
DR   BioMuta; MFSD13A; -.
DR   DMDM; 122012175; -.
DR   MassIVE; Q14CX5; -.
DR   PaxDb; Q14CX5; -.
DR   PeptideAtlas; Q14CX5; -.
DR   PRIDE; Q14CX5; -.
DR   ProteomicsDB; 60334; -.
DR   ABCD; Q14CX5; 11 sequenced antibodies.
DR   Antibodypedia; 18048; 27 antibodies from 12 providers.
DR   DNASU; 79847; -.
DR   Ensembl; ENST00000238936.8; ENSP00000238936.3; ENSG00000138111.14.
DR   GeneID; 79847; -.
DR   KEGG; hsa:79847; -.
DR   MANE-Select; ENST00000238936.8; ENSP00000238936.3; NM_024789.4; NP_079065.2.
DR   UCSC; uc001kvt.4; human.
DR   CTD; 79847; -.
DR   DisGeNET; 79847; -.
DR   GeneCards; MFSD13A; -.
DR   HGNC; HGNC:26196; MFSD13A.
DR   HPA; ENSG00000138111; Low tissue specificity.
DR   neXtProt; NX_Q14CX5; -.
DR   OpenTargets; ENSG00000138111; -.
DR   PharmGKB; PA162406011; -.
DR   VEuPathDB; HostDB:ENSG00000138111; -.
DR   eggNOG; ENOG502QSW5; Eukaryota.
DR   GeneTree; ENSGT00940000160317; -.
DR   HOGENOM; CLU_034985_0_0_1; -.
DR   InParanoid; Q14CX5; -.
DR   OMA; FVCMNLV; -.
DR   OrthoDB; 1041483at2759; -.
DR   PhylomeDB; Q14CX5; -.
DR   TreeFam; TF313122; -.
DR   PathwayCommons; Q14CX5; -.
DR   SignaLink; Q14CX5; -.
DR   BioGRID-ORCS; 79847; 15 hits in 1073 CRISPR screens.
DR   ChiTaRS; MFSD13A; human.
DR   GenomeRNAi; 79847; -.
DR   Pharos; Q14CX5; Tdark.
DR   PRO; PR:Q14CX5; -.
DR   Proteomes; UP000005640; Chromosome 10.
DR   RNAct; Q14CX5; protein.
DR   Bgee; ENSG00000138111; Expressed in right hemisphere of cerebellum and 100 other tissues.
DR   ExpressionAtlas; Q14CX5; baseline and differential.
DR   Genevisible; Q14CX5; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR040035; TMEM180.
DR   PANTHER; PTHR28658; PTHR28658; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   1: Evidence at protein level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..517
FT                   /note="Transmembrane protein 180"
FT                   /id="PRO_0000256224"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        52..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        164..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        266..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        306..326
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        332..354
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        401..421
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        466..486
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        371
FT                   /note="T -> P (in Ref. 2; AAH67531)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        489
FT                   /note="F -> S (in Ref. 2; AAH57787)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        505
FT                   /note="N -> S (in Ref. 2; AAH67530/AAH67531)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   517 AA;  57381 MW;  50CC5110F967D588 CRC64;
     MGLGQPQAWL LGLPTAVVYG SLALFTTILH NVFLLYYVDT FVSVYKINKM AFWVGETVFL
     LWNSLNDPLF GWLSDRQFLS SQPRSGAGLS SRAVVLARVQ ALGWHGPLLA LSFLAFWVPW
     APAGLQFLLC LCLYDGFLTL VDLHHHALLA DLALSAHDRT HLNFYCSLFS AAGSLSVFAS
     YAFWNKEDFS SFRAFCVTLA VSSGLGFLGA TQLLRRRVEA ARKDPGCSGL VVDSGLCGEE
     LLVGSEEADS ITLGRYLRQL ARHRNFLWFV SMDLVQVFHC HFNSNFFPLF LEHLLSDHIS
     LSTGSILLGL SYVAPHLNNL YFLSLCRRWG VYAVVRGLFL LKLGLSLLML LAGPDHLSLL
     CLFIASNRVF TEGTCKLLTL VVTDLVDEDL VLNHRKQAAS ALLFGMVALV TKPGQTFAPL
     LGTWLLCFYT GHDLFQQSLI TPVGSAHPWP EPPAPAPAQA PTLRQGCFYL LVLVPITCAL
     LQLFTWSQFT LHGRRLHMVK AQRQNLSQAQ TLDVKMV
 
 
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