MF13A_MOUSE
ID MF13A_MOUSE Reviewed; 519 AA.
AC Q6PDE8; Q80Y49; Q8CD35;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Transmembrane protein 180 {ECO:0000312|MGI:MGI:1922396};
DE AltName: Full=Major facilitator superfamily domain-containing 13A {ECO:0000250|UniProtKB:Q14CX5};
GN Name=Mfsd13a {ECO:0000250|UniProtKB:Q14CX5};
GN Synonyms=Tmem180 {ECO:0000312|MGI:MGI:1922396};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Bone marrow, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon, and Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC27447.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK031554; BAC27447.1; ALT_FRAME; mRNA.
DR EMBL; AK151797; BAE30697.1; -; mRNA.
DR EMBL; AK161305; BAE36310.1; -; mRNA.
DR EMBL; AK170247; BAE41659.1; -; mRNA.
DR EMBL; BC049142; AAH49142.1; -; mRNA.
DR EMBL; BC058746; AAH58746.1; -; mRNA.
DR CCDS; CCDS29877.1; -.
DR RefSeq; NP_083462.2; NM_029186.2.
DR AlphaFoldDB; Q6PDE8; -.
DR SMR; Q6PDE8; -.
DR STRING; 10090.ENSMUSP00000084189; -.
DR GlyGen; Q6PDE8; 1 site.
DR PhosphoSitePlus; Q6PDE8; -.
DR PaxDb; Q6PDE8; -.
DR PRIDE; Q6PDE8; -.
DR Antibodypedia; 18048; 27 antibodies from 12 providers.
DR Ensembl; ENSMUST00000086969; ENSMUSP00000084189; ENSMUSG00000025227.
DR Ensembl; ENSMUST00000128041; ENSMUSP00000119072; ENSMUSG00000025227.
DR GeneID; 75146; -.
DR KEGG; mmu:75146; -.
DR UCSC; uc008htk.1; mouse.
DR CTD; 79847; -.
DR MGI; MGI:1922396; Mfsd13a.
DR VEuPathDB; HostDB:ENSMUSG00000025227; -.
DR eggNOG; ENOG502QSW5; Eukaryota.
DR GeneTree; ENSGT00940000160317; -.
DR HOGENOM; CLU_034985_0_0_1; -.
DR InParanoid; Q6PDE8; -.
DR OMA; FVCMNLV; -.
DR OrthoDB; 1041483at2759; -.
DR PhylomeDB; Q6PDE8; -.
DR TreeFam; TF313122; -.
DR BioGRID-ORCS; 75146; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Mfsd13a; mouse.
DR PRO; PR:Q6PDE8; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q6PDE8; protein.
DR Bgee; ENSMUSG00000025227; Expressed in olfactory tubercle and 226 other tissues.
DR ExpressionAtlas; Q6PDE8; baseline and differential.
DR Genevisible; Q6PDE8; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR040035; TMEM180.
DR PANTHER; PTHR28658; PTHR28658; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..519
FT /note="Transmembrane protein 180"
FT /id="PRO_0000256225"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..123
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..286
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 306..326
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 332..354
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 401..421
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 468..488
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 250
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 519 AA; 57898 MW; C8D1DFB2E754500A CRC64;
MGLDWPQAWL LGLPIAVVYG SLALFTSILH NVFLLYYVDT FVSVYKINKV SFWVGETVFL
LWNSFNDPLF GWLSDRQLLS SQPRSGAGLS SRDVVLTRVR ALGWHGPLLA LSFLAFWVPW
APAGLQFLLC LCLYDGFLTL VDLHHHALLA DLALSSHDRT HLNFYCSLFS AAGSLSVFAS
YAFWNKEDFS SFRAFCVVLA AGSGLGFLGT TQLLKRQIEA TRRDRGCPGL DLDGGVCEEE
PPVGGEEAGN ITLGQYLRQL ARHQNFLWFV GMDLVQVFHC HFNSNFFPLF LEHLLSDHIS
LSTGSFLLGI SYVAPHLNNL YFLPLCRRWG VYAVVRGLFL LKLSLSLLML LAGPDHPGLL
CFFIASNRVF TEGTCKLLTL VVTDLVDEDL VLNHRKQAAS ALLFGMVALV TKPGQTFAPL
LGTWLLCFYT GHDLFQQSPM TPVGSVRPWP ELPAPAPAPA QAPTLRQGCF YLLVFVPITC
ALLQLFTWSQ FTLHGRRLRT VKAQRQNLAQ IHTLNIKMV
