MF14A_HUMAN
ID MF14A_HUMAN Reviewed; 490 AA.
AC Q96MC6; Q6P2N7; Q8N8K2; Q8NBV3; Q96NY0; Q9NT25;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Hippocampus abundant transcript 1 protein {ECO:0000312|HGNC:HGNC:23363};
DE AltName: Full=Major facilitator superfamily domain-containing 14A {ECO:0000312|HGNC:HGNC:23363};
DE AltName: Full=Putative tetracycline transporter-like protein;
GN Name=MFSD14A {ECO:0000312|HGNC:HGNC:23363};
GN Synonyms=HIAT1 {ECO:0000312|HGNC:HGNC:23363};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Stomach;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Mathur B.N., Turner C.A. Jr.;
RT "Lexicon Genetics incorporated full-length cloning.";
RL Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 304-490.
RC TISSUE=Brain;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 116-490.
RC TISSUE=Duodenum;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP ACETYLATION AT MET-1.
RX PubMed=25732826; DOI=10.1016/j.celrep.2015.01.053;
RA Aksnes H., Van Damme P., Goris M., Starheim K.K., Marie M., Stoeve S.I.,
RA Hoel C., Kalvik T.V., Hole K., Glomnes N., Furnes C., Ljostveit S.,
RA Ziegler M., Niere M., Gevaert K., Arnesen T.;
RT "An organellar nalpha-acetyltransferase, naa60, acetylates cytosolic N
RT termini of transmembrane proteins and maintains Golgi integrity.";
RL Cell Rep. 10:1362-1374(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC04836.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC11473.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK057172; BAB71375.1; -; mRNA.
DR EMBL; AK075208; BAC11473.1; ALT_INIT; mRNA.
DR EMBL; AK096669; BAC04836.1; ALT_INIT; mRNA.
DR EMBL; AF427492; AAL25115.1; -; mRNA.
DR EMBL; AL137576; CAB70819.2; -; mRNA.
DR EMBL; BC064409; AAH64409.1; -; mRNA.
DR CCDS; CCDS763.1; -.
DR PIR; T46272; T46272.
DR RefSeq; NP_149044.2; NM_033055.2.
DR AlphaFoldDB; Q96MC6; -.
DR SMR; Q96MC6; -.
DR BioGRID; 122223; 4.
DR IntAct; Q96MC6; 1.
DR MINT; Q96MC6; -.
DR STRING; 9606.ENSP00000359171; -.
DR TCDB; 2.A.1.2.104; the major facilitator superfamily (mfs).
DR GlyGen; Q96MC6; 2 sites.
DR iPTMnet; Q96MC6; -.
DR PhosphoSitePlus; Q96MC6; -.
DR BioMuta; MFSD14A; -.
DR DMDM; 54036072; -.
DR EPD; Q96MC6; -.
DR jPOST; Q96MC6; -.
DR MassIVE; Q96MC6; -.
DR MaxQB; Q96MC6; -.
DR PaxDb; Q96MC6; -.
DR PeptideAtlas; Q96MC6; -.
DR PRIDE; Q96MC6; -.
DR ProteomicsDB; 77333; -.
DR Antibodypedia; 53425; 95 antibodies from 14 providers.
DR DNASU; 64645; -.
DR Ensembl; ENST00000370152.8; ENSP00000359171.3; ENSG00000156875.14.
DR GeneID; 64645; -.
DR KEGG; hsa:64645; -.
DR MANE-Select; ENST00000370152.8; ENSP00000359171.3; NM_033055.3; NP_149044.2.
DR UCSC; uc001dst.4; human.
DR CTD; 64645; -.
DR DisGeNET; 64645; -.
DR GeneCards; MFSD14A; -.
DR HGNC; HGNC:23363; MFSD14A.
DR HPA; ENSG00000156875; Tissue enhanced (parathyroid).
DR neXtProt; NX_Q96MC6; -.
DR OpenTargets; ENSG00000156875; -.
DR PharmGKB; PA134910737; -.
DR VEuPathDB; HostDB:ENSG00000156875; -.
DR eggNOG; KOG2816; Eukaryota.
DR GeneTree; ENSGT00940000157395; -.
DR HOGENOM; CLU_001265_10_5_1; -.
DR InParanoid; Q96MC6; -.
DR OMA; VRAGSWK; -.
DR OrthoDB; 582396at2759; -.
DR PhylomeDB; Q96MC6; -.
DR TreeFam; TF313511; -.
DR PathwayCommons; Q96MC6; -.
DR SignaLink; Q96MC6; -.
DR BioGRID-ORCS; 64645; 16 hits in 1067 CRISPR screens.
DR ChiTaRS; MFSD14A; human.
DR GenomeRNAi; 64645; -.
DR Pharos; Q96MC6; Tdark.
DR PRO; PR:Q96MC6; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q96MC6; protein.
DR Bgee; ENSG00000156875; Expressed in smooth muscle tissue and 99 other tissues.
DR Genevisible; Q96MC6; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0001675; P:acrosome assembly; IEA:Ensembl.
DR GO; GO:0030382; P:sperm mitochondrion organization; IEA:Ensembl.
DR GO; GO:0007289; P:spermatid nucleus differentiation; IEA:Ensembl.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR InterPro; IPR001958; Tet-R_TetA/multi-R_MdtG.
DR Pfam; PF07690; MFS_1; 1.
DR PRINTS; PR01035; TCRTETA.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 1: Evidence at protein level;
KW Acetylation; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..490
FT /note="Hippocampus abundant transcript 1 protein"
FT /id="PRO_0000084856"
FT TOPO_DOM 1..40
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..61
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 62..74
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 96..103
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 125..126
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 148..160
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..181
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 182..188
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..209
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 210..243
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..284
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 285..305
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 306..313
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 314..334
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 335..337
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 338..358
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 359..379
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 380..400
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 401..427
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 428..448
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 449..490
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 465..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000269|PubMed:25732826"
FT CARBOHYD 12
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 453
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 142
FT /note="V -> M (in Ref. 1; BAB71375)"
FT /evidence="ECO:0000305"
FT CONFLICT 447
FT /note="F -> L (in Ref. 3; CAB70819)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 490 AA; 53027 MW; 1244693E149F95AD CRC64;
MTQGKKKKRA ANRSIMLAKK IIIKDGGTPQ GIGSPSVYHA VIVIFLEFFA WGLLTAPTLV
VLHETFPKHT FLMNGLIQGV KGLLSFLSAP LIGALSDVWG RKSFLLLTVF FTCAPIPLMK
ISPWWYFAVI SVSGVFAVTF SVVFAYVADI TQEHERSMAY GLVSATFAAS LVTSPAIGAY
LGRVYGDSLV VVLATAIALL DICFILVAVP ESLPEKMRPA SWGAPISWEQ ADPFASLKKV
GQDSIVLLIC ITVFLSYLPE AGQYSSFFLY LRQIMKFSPE SVAAFIAVLG ILSIIAQTIV
LSLLMRSIGN KNTILLGLGF QILQLAWYGF GSEPWMMWAA GAVAAMSSIT FPAVSALVSR
TADADQQGVV QGMITGIRGL CNGLGPALYG FIFYIFHVEL KELPITGTDL GTNTSPQHHF
EQNSIIPGPP FLFGACSVLL ALLVALFIPE HTNLSLRSSS WRKHCGSHSH PHNTQAPGEA
KEPLLQDTNV
