MF14A_MOUSE
ID MF14A_MOUSE Reviewed; 490 AA.
AC P70187; Q3TY74; Q9DBS0;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 3.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Hippocampus abundant transcript 1 protein {ECO:0000250|UniProtKB:Q96MC6};
DE AltName: Full=Major facilitator superfamily domain-containing 14A {ECO:0000250|UniProtKB:Q96MC6};
GN Name=Mfsd14a {ECO:0000250|UniProtKB:Q96MC6};
GN Synonyms=Hiat1 {ECO:0000250|UniProtKB:Q96MC6};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC STRAIN=C57BL/6J; TISSUE=Hippocampus;
RX PubMed=9299464; DOI=10.1006/bbrc.1997.7252;
RA Matsuo N., Kawamoto S., Matsubara K., Okubo K.;
RT "Cloning of a cDNA encoding a novel sugar transporter expressed in the
RT neonatal mouse hippocampus.";
RL Biochem. Biophys. Res. Commun. 238:126-129(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Egg, Lung, Thymus, and Visual cortex;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in various tissues.
CC {ECO:0000269|PubMed:9299464}.
CC -!- DEVELOPMENTAL STAGE: Evenly distributed throughout the neonatal brain.
CC {ECO:0000269|PubMed:9299464}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
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DR EMBL; D88315; BAA22622.1; -; mRNA.
DR EMBL; AK004779; BAB23557.1; -; mRNA.
DR EMBL; AK135865; BAE22703.1; -; mRNA.
DR EMBL; AK158838; BAE34689.1; -; mRNA.
DR EMBL; AK169626; BAE41267.1; -; mRNA.
DR EMBL; CH466532; EDL12373.1; -; Genomic_DNA.
DR EMBL; BC118047; AAI18048.1; -; mRNA.
DR CCDS; CCDS17790.1; -.
DR PIR; JC5641; JC5641.
DR RefSeq; NP_032272.2; NM_008246.2.
DR AlphaFoldDB; P70187; -.
DR SMR; P70187; -.
DR STRING; 10090.ENSMUSP00000029570; -.
DR GlyGen; P70187; 2 sites.
DR PhosphoSitePlus; P70187; -.
DR EPD; P70187; -.
DR MaxQB; P70187; -.
DR PaxDb; P70187; -.
DR PeptideAtlas; P70187; -.
DR PRIDE; P70187; -.
DR ProteomicsDB; 295557; -.
DR DNASU; 15247; -.
DR Ensembl; ENSMUST00000029570; ENSMUSP00000029570; ENSMUSG00000089911.
DR GeneID; 15247; -.
DR KEGG; mmu:15247; -.
DR UCSC; uc008rco.2; mouse.
DR CTD; 64645; -.
DR MGI; MGI:1201609; Mfsd14a.
DR VEuPathDB; HostDB:ENSMUSG00000089911; -.
DR eggNOG; KOG2816; Eukaryota.
DR GeneTree; ENSGT00940000157395; -.
DR HOGENOM; CLU_001265_10_5_1; -.
DR InParanoid; P70187; -.
DR OMA; VRAGSWK; -.
DR OrthoDB; 582396at2759; -.
DR PhylomeDB; P70187; -.
DR TreeFam; TF313511; -.
DR BioGRID-ORCS; 15247; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Mfsd14a; mouse.
DR PRO; PR:P70187; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; P70187; protein.
DR Bgee; ENSMUSG00000089911; Expressed in spermatocyte and 243 other tissues.
DR Genevisible; P70187; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0001675; P:acrosome assembly; IMP:MGI.
DR GO; GO:0030382; P:sperm mitochondrion organization; IMP:MGI.
DR GO; GO:0007286; P:spermatid development; IMP:MGI.
DR GO; GO:0007289; P:spermatid nucleus differentiation; IMP:MGI.
DR GO; GO:0007283; P:spermatogenesis; IMP:MGI.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR InterPro; IPR001958; Tet-R_TetA/multi-R_MdtG.
DR Pfam; PF07690; MFS_1; 1.
DR PRINTS; PR01035; TCRTETA.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..490
FT /note="Hippocampus abundant transcript 1 protein"
FT /id="PRO_0000084857"
FT TOPO_DOM 1..40
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..61
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 62..74
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 96..103
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 125..126
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 148..160
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..181
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 182..188
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..209
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 210..243
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..284
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 285..305
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 306..313
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 314..334
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 335..337
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 338..358
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 359..379
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 380..400
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 401..427
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 428..448
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 449..490
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 466..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q96MC6"
FT CARBOHYD 12
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 453
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 183..184
FT /note="RV -> QM (in Ref. 1; BAA22622)"
FT /evidence="ECO:0000305"
FT CONFLICT 272
FT /note="R -> K (in Ref. 1; BAA22622)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 490 AA; 53000 MW; 1251B30E149F95AD CRC64;
MTQGKKKKRA ANRSIMLAKK IIIKDGGTPQ GIGSPSVYHA VIVIFLEFFA WGLLTAPTLV
VLHETFPKHT FLMNGLIQGV KGLLSFLSAP LIGALSDVWG RKSFLLLTVF FTCAPIPLMK
ISPWWYFAVI SVSGVFAVTF SVVFAYVADI TQEHERSMAY GLVSATFAAS LVTSPAIGAY
LGRVYGDSLV VVLATAIALL DICFILVAVP ESLPEKMRPA SWGAPISWEQ ADPFASLKKV
GQDSIVLLIC ITVFLSYLPE AGQYSSFFLY LRQIMKFSPE SVAAFIAVLG ILSIIAQTIV
LSLLMRSIGN KNTILLGLGF QILQLAWYGF GSEPWMMWAA GAVAAMSSIT FPAVSALVSR
TADADQQGVV QGMITGIRGL CNGLGPALYG FIFYIFHVEL KELPITGTDL GTNTSPQHHF
EQNSIIPGPP FLFGACSVLL ALLVALFIPE HTNLSLRSSS WRKHCGSHSH PHSTQAPGEA
KEPLLQDTNV
