MF14B_HUMAN
ID MF14B_HUMAN Reviewed; 506 AA.
AC Q5SR56; B4DUE6; E9PD58; Q3KQT4; Q53GU5; Q8WU95; Q96SM4;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 26-MAY-2009, sequence version 3.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Hippocampus abundant transcript-like protein 1 {ECO:0000312|HGNC:HGNC:23376};
DE AltName: Full=Major facilitator superfamily domain-containing 14B {ECO:0000312|HGNC:HGNC:23376};
GN Name=MFSD14B {ECO:0000312|HGNC:HGNC:23376};
GN Synonyms=HIATL1 {ECO:0000312|HGNC:HGNC:23376};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 143-506 (ISOFORM 1).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT LEU-406.
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 140-506 (ISOFORM 1).
RC TISSUE=Liver;
RA Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
RA Tanaka A., Yokoyama S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- INTERACTION:
CC Q5SR56; Q15848: ADIPOQ; NbExp=3; IntAct=EBI-373355, EBI-10827839;
CC Q5SR56; Q9NRZ7: AGPAT3; NbExp=3; IntAct=EBI-373355, EBI-2803601;
CC Q5SR56; Q9NRZ5: AGPAT4; NbExp=3; IntAct=EBI-373355, EBI-1754287;
CC Q5SR56; Q15041: ARL6IP1; NbExp=3; IntAct=EBI-373355, EBI-714543;
CC Q5SR56; Q9HD20-3: ATP13A1; NbExp=3; IntAct=EBI-373355, EBI-12069500;
CC Q5SR56; Q12983: BNIP3; NbExp=3; IntAct=EBI-373355, EBI-749464;
CC Q5SR56; Q8WVX3-2: C4orf3; NbExp=3; IntAct=EBI-373355, EBI-12003442;
CC Q5SR56; Q8NHW4: CCL4L2; NbExp=3; IntAct=EBI-373355, EBI-10271156;
CC Q5SR56; Q9BXR6: CFHR5; NbExp=3; IntAct=EBI-373355, EBI-11579371;
CC Q5SR56; O14493: CLDN4; NbExp=3; IntAct=EBI-373355, EBI-9316372;
CC Q5SR56; Q96MX0: CMTM3; NbExp=3; IntAct=EBI-373355, EBI-7247651;
CC Q5SR56; P21964: COMT; NbExp=3; IntAct=EBI-373355, EBI-372265;
CC Q5SR56; Q8N6G5: CSGALNACT2; NbExp=3; IntAct=EBI-373355, EBI-10267100;
CC Q5SR56; O43169: CYB5B; NbExp=3; IntAct=EBI-373355, EBI-1058710;
CC Q5SR56; Q9BQA9: CYBC1; NbExp=3; IntAct=EBI-373355, EBI-2680384;
CC Q5SR56; Q9H1M4: DEFB127; NbExp=3; IntAct=EBI-373355, EBI-10305240;
CC Q5SR56; Q96LL9: DNAJC30; NbExp=3; IntAct=EBI-373355, EBI-8639143;
CC Q5SR56; Q9BV81: EMC6; NbExp=3; IntAct=EBI-373355, EBI-2820492;
CC Q5SR56; Q9UKR5: ERG28; NbExp=3; IntAct=EBI-373355, EBI-711490;
CC Q5SR56; Q14318: FKBP8; NbExp=3; IntAct=EBI-373355, EBI-724839;
CC Q5SR56; Q01740: FMO1; NbExp=3; IntAct=EBI-373355, EBI-12701460;
CC Q5SR56; Q9BWH2: FUNDC2; NbExp=3; IntAct=EBI-373355, EBI-714482;
CC Q5SR56; Q8WWP7: GIMAP1; NbExp=3; IntAct=EBI-373355, EBI-11991950;
CC Q5SR56; O14653: GOSR2; NbExp=3; IntAct=EBI-373355, EBI-4401517;
CC Q5SR56; Q14416: GRM2; NbExp=3; IntAct=EBI-373355, EBI-10232876;
CC Q5SR56; Q86UP2-3: KTN1; NbExp=3; IntAct=EBI-373355, EBI-12007212;
CC Q5SR56; O43561-2: LAT; NbExp=3; IntAct=EBI-373355, EBI-8070286;
CC Q5SR56; O95214: LEPROTL1; NbExp=3; IntAct=EBI-373355, EBI-750776;
CC Q5SR56; Q7L5N7: LPCAT2; NbExp=3; IntAct=EBI-373355, EBI-4280011;
CC Q5SR56; Q7Z4F1: LRP10; NbExp=3; IntAct=EBI-373355, EBI-2830349;
CC Q5SR56; A0A0C4DFN3: MGLL; NbExp=3; IntAct=EBI-373355, EBI-12866138;
CC Q5SR56; P11836: MS4A1; NbExp=3; IntAct=EBI-373355, EBI-2808234;
CC Q5SR56; Q9UHE5: NAT8; NbExp=3; IntAct=EBI-373355, EBI-2863634;
CC Q5SR56; Q8N912: NRAC; NbExp=3; IntAct=EBI-373355, EBI-12051377;
CC Q5SR56; Q9P0S3: ORMDL1; NbExp=3; IntAct=EBI-373355, EBI-1054848;
CC Q5SR56; Q9Y5Y5: PEX16; NbExp=3; IntAct=EBI-373355, EBI-981985;
CC Q5SR56; Q99640-2: PKMYT1; NbExp=3; IntAct=EBI-373355, EBI-12257782;
CC Q5SR56; Q59EV6: PPGB; NbExp=3; IntAct=EBI-373355, EBI-14210385;
CC Q5SR56; Q7Z6L0: PRRT2; NbExp=3; IntAct=EBI-373355, EBI-722696;
CC Q5SR56; Q9Y225-2: RNF24; NbExp=3; IntAct=EBI-373355, EBI-13044680;
CC Q5SR56; Q9NTJ5: SACM1L; NbExp=3; IntAct=EBI-373355, EBI-3917235;
CC Q5SR56; O00767: SCD; NbExp=3; IntAct=EBI-373355, EBI-2684237;
CC Q5SR56; Q9Y6X1: SERP1; NbExp=3; IntAct=EBI-373355, EBI-10329948;
CC Q5SR56; Q8N6R1: SERP2; NbExp=3; IntAct=EBI-373355, EBI-749270;
CC Q5SR56; Q96AG3: SLC25A46; NbExp=3; IntAct=EBI-373355, EBI-10281975;
CC Q5SR56; Q9NUM3: SLC39A9; NbExp=3; IntAct=EBI-373355, EBI-2823239;
CC Q5SR56; Q8N2U9: SLC66A2; NbExp=3; IntAct=EBI-373355, EBI-3907610;
CC Q5SR56; Q0VAQ4: SMAGP; NbExp=3; IntAct=EBI-373355, EBI-10226799;
CC Q5SR56; Q13277: STX3; NbExp=3; IntAct=EBI-373355, EBI-1394295;
CC Q5SR56; Q9NZ01: TECR; NbExp=3; IntAct=EBI-373355, EBI-2877718;
CC Q5SR56; C9JKN6: THSD7B; NbExp=3; IntAct=EBI-373355, EBI-17192156;
CC Q5SR56; Q9NPL8: TIMMDC1; NbExp=3; IntAct=EBI-373355, EBI-6268651;
CC Q5SR56; P55061: TMBIM6; NbExp=3; IntAct=EBI-373355, EBI-1045825;
CC Q5SR56; Q9NRX6: TMEM167B; NbExp=3; IntAct=EBI-373355, EBI-17684533;
CC Q5SR56; Q96HP8: TMEM176A; NbExp=3; IntAct=EBI-373355, EBI-2800645;
CC Q5SR56; Q96HH6: TMEM19; NbExp=3; IntAct=EBI-373355, EBI-741829;
CC Q5SR56; Q9BTX3: TMEM208; NbExp=3; IntAct=EBI-373355, EBI-12876824;
CC Q5SR56; Q8NBD8: TMEM229B; NbExp=3; IntAct=EBI-373355, EBI-12195227;
CC Q5SR56; Q8WW34-2: TMEM239; NbExp=3; IntAct=EBI-373355, EBI-11528917;
CC Q5SR56; Q9Y320: TMX2; NbExp=3; IntAct=EBI-373355, EBI-6447886;
CC Q5SR56; Q6ZUI0: TPRG1; NbExp=3; IntAct=EBI-373355, EBI-17249488;
CC Q5SR56; Q9NSU2-1: TREX1; NbExp=3; IntAct=EBI-373355, EBI-16746122;
CC Q5SR56; A0AVG3: TSNARE1; NbExp=3; IntAct=EBI-373355, EBI-12003468;
CC Q5SR56; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-373355, EBI-11988865;
CC Q5SR56; Q9Y385: UBE2J1; NbExp=3; IntAct=EBI-373355, EBI-988826;
CC Q5SR56; Q53HI1: UNC50; NbExp=3; IntAct=EBI-373355, EBI-7601760;
CC Q5SR56; Q9NZ43: USE1; NbExp=3; IntAct=EBI-373355, EBI-742842;
CC Q5SR56; Q9Y548: YIPF1; NbExp=3; IntAct=EBI-373355, EBI-7850136;
CC Q5SR56; Q9BWQ6: YIPF2; NbExp=3; IntAct=EBI-373355, EBI-751204;
CC Q5SR56; Q9BSR8: YIPF4; NbExp=3; IntAct=EBI-373355, EBI-751253;
CC Q5SR56; Q96EC8: YIPF6; NbExp=3; IntAct=EBI-373355, EBI-751210;
CC Q5SR56; Q6UX98: ZDHHC24; NbExp=3; IntAct=EBI-373355, EBI-10254561;
CC Q5SR56; O95159: ZFPL1; NbExp=3; IntAct=EBI-373355, EBI-718439;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5SR56-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5SR56-2; Sequence=VSP_056692, VSP_056693, VSP_056694;
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI06063.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAB55274.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAD96556.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK027659; BAB55274.1; ALT_INIT; mRNA.
DR EMBL; AK300615; BAG62308.1; -; mRNA.
DR EMBL; AL358232; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL691447; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC106062; AAI06063.1; ALT_INIT; mRNA.
DR EMBL; BC021093; AAH21093.2; -; mRNA.
DR EMBL; AK222836; BAD96556.1; ALT_INIT; mRNA.
DR CCDS; CCDS6710.2; -. [Q5SR56-1]
DR RefSeq; NP_115947.2; NM_032558.2. [Q5SR56-1]
DR RefSeq; XP_016870710.1; XM_017015221.1. [Q5SR56-2]
DR AlphaFoldDB; Q5SR56; -.
DR SMR; Q5SR56; -.
DR BioGRID; 124166; 78.
DR IntAct; Q5SR56; 75.
DR STRING; 9606.ENSP00000364493; -.
DR TCDB; 2.A.1.2.30; the major facilitator superfamily (mfs).
DR GlyGen; Q5SR56; 1 site.
DR iPTMnet; Q5SR56; -.
DR PhosphoSitePlus; Q5SR56; -.
DR BioMuta; MFSD14B; -.
DR DMDM; 238054382; -.
DR EPD; Q5SR56; -.
DR jPOST; Q5SR56; -.
DR MassIVE; Q5SR56; -.
DR MaxQB; Q5SR56; -.
DR PaxDb; Q5SR56; -.
DR PeptideAtlas; Q5SR56; -.
DR PRIDE; Q5SR56; -.
DR ProteomicsDB; 5181; -.
DR ProteomicsDB; 63839; -. [Q5SR56-1]
DR Antibodypedia; 3023; 60 antibodies from 17 providers.
DR DNASU; 84641; -.
DR Ensembl; ENST00000375344.8; ENSP00000364493.3; ENSG00000148110.17. [Q5SR56-1]
DR GeneID; 84641; -.
DR KEGG; hsa:84641; -.
DR MANE-Select; ENST00000375344.8; ENSP00000364493.3; NM_032558.3; NP_115947.2.
DR UCSC; uc004aur.4; human. [Q5SR56-1]
DR CTD; 84641; -.
DR DisGeNET; 84641; -.
DR GeneCards; MFSD14B; -.
DR HGNC; HGNC:23376; MFSD14B.
DR HPA; ENSG00000148110; Low tissue specificity.
DR neXtProt; NX_Q5SR56; -.
DR OpenTargets; ENSG00000148110; -.
DR PharmGKB; PA142671691; -.
DR VEuPathDB; HostDB:ENSG00000148110; -.
DR eggNOG; KOG2816; Eukaryota.
DR GeneTree; ENSGT00940000156081; -.
DR HOGENOM; CLU_001265_10_5_1; -.
DR InParanoid; Q5SR56; -.
DR OMA; IRPVSWG; -.
DR OrthoDB; 763423at2759; -.
DR PhylomeDB; Q5SR56; -.
DR TreeFam; TF313511; -.
DR PathwayCommons; Q5SR56; -.
DR SignaLink; Q5SR56; -.
DR BioGRID-ORCS; 84641; 7 hits in 1060 CRISPR screens.
DR ChiTaRS; MFSD14B; human.
DR GenomeRNAi; 84641; -.
DR Pharos; Q5SR56; Tdark.
DR PRO; PR:Q5SR56; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q5SR56; protein.
DR Bgee; ENSG00000148110; Expressed in oviduct epithelium and 182 other tissues.
DR ExpressionAtlas; Q5SR56; baseline and differential.
DR Genevisible; Q5SR56; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR InterPro; IPR001958; Tet-R_TetA/multi-R_MdtG.
DR Pfam; PF07690; MFS_1; 1.
DR PRINTS; PR01035; TCRTETA.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..506
FT /note="Hippocampus abundant transcript-like protein 1"
FT /id="PRO_0000239229"
FT TOPO_DOM 1..49
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 71..82
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 83..103
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 104..111
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 133..134
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 156..168
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 190..196
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..255
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 256..276
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 277..281
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 282..302
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 303..319
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 320..340
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 341
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 342..362
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 363..387
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 388..408
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 409..428
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 429..449
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 450..506
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 457..481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..474
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 463
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..65
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056692"
FT VAR_SEQ 344..376
FT /note="MMWAAGTVAAMSSITFPAISALVSRNAESDQQG -> SCPGDHNWNKRTMQW
FT PGASTVWLHILHVPCGTD (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056693"
FT VAR_SEQ 377..506
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056694"
FT VARIANT 406
FT /note="V -> L (in dbSNP:rs17851857)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_055401"
FT CONFLICT 367
FT /note="S -> T (in Ref. 4; BAB55274)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 506 AA; 54545 MW; 4CD09B8A06EC6EA5 CRC64;
MSVEPPPELE EKAASEPEAG AMPEKRAGAQ AAGSTWLQGF GRPSVYHAAI VIFLEFFAWG
LLTTPMLTVL HETFSQHTFL MNGLIQGVKG LLSFLSAPLI GALSDVWGRK PFLLGTVFFT
CFPIPLMRIS PWWYFAMISV SGVFSVTFSV IFAYVADVTQ EHERSTAYGW VSATFAASLV
SSPAIGAYLS ASYGDSLVVL VATVVALLDI CFILVAVPES LPEKMRPVSW GAQISWKQAD
PFASLKKVGK DSTVLLICIT VFLSYLPEAG QYSSFFLYLR QVIGFGSVKI AAFIAMVGIL
SIVAQTAFLS ILMRSLGNKN TVLLGLGFQM LQLAWYGFGS QAWMMWAAGT VAAMSSITFP
AISALVSRNA ESDQQGVAQG IITGIRGLCN GLGPALYGFI FYMFHVELTE LGPKLNSNNV
PLQGAVIPGP PFLFGACIVL MSFLVALFIP EYSKASGVQK HSNSSSGSLT NTPERGSDED
IEPLLQDSSI WELSSFEEPG NQCTEL
