MF14B_MOUSE
ID MF14B_MOUSE Reviewed; 507 AA.
AC Q8CIA9; G3UVV2; Q8VCW0;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 3.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Hippocampus abundant transcript-like protein 1 {ECO:0000312|MGI:MGI:1913881};
DE AltName: Full=Major facilitator superfamily domain-containing 14B {ECO:0000250|UniProtKB:Q5SR56};
GN Name=Mfsd14b {ECO:0000250|UniProtKB:Q5SR56};
GN Synonyms=Hiatl1 {ECO:0000312|MGI:MGI:1913881};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Heart;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH18395.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAH33469.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAE27291.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK146596; BAE27291.1; ALT_INIT; mRNA.
DR EMBL; AC154713; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466631; EDL16253.1; -; Genomic_DNA.
DR EMBL; BC018395; AAH18395.1; ALT_INIT; mRNA.
DR EMBL; BC033469; AAH33469.1; ALT_INIT; mRNA.
DR CCDS; CCDS26603.2; -.
DR RefSeq; NP_001077370.1; NM_001083901.1.
DR RefSeq; NP_598441.3; NM_133680.3.
DR RefSeq; XP_011242852.1; XM_011244550.2.
DR AlphaFoldDB; Q8CIA9; -.
DR SMR; Q8CIA9; -.
DR BioGRID; 211609; 1.
DR STRING; 10090.ENSMUSP00000118180; -.
DR GlyGen; Q8CIA9; 2 sites.
DR iPTMnet; Q8CIA9; -.
DR PhosphoSitePlus; Q8CIA9; -.
DR EPD; Q8CIA9; -.
DR MaxQB; Q8CIA9; -.
DR PaxDb; Q8CIA9; -.
DR PRIDE; Q8CIA9; -.
DR ProteomicsDB; 295890; -.
DR Antibodypedia; 3023; 60 antibodies from 17 providers.
DR DNASU; 66631; -.
DR Ensembl; ENSMUST00000054730; ENSMUSP00000062566; ENSMUSG00000038212.
DR Ensembl; ENSMUST00000155487; ENSMUSP00000118180; ENSMUSG00000038212.
DR GeneID; 66631; -.
DR KEGG; mmu:66631; -.
DR UCSC; uc007qzc.1; mouse.
DR CTD; 84641; -.
DR MGI; MGI:1913881; Mfsd14b.
DR VEuPathDB; HostDB:ENSMUSG00000038212; -.
DR eggNOG; KOG2816; Eukaryota.
DR GeneTree; ENSGT00940000156081; -.
DR HOGENOM; CLU_001265_10_5_1; -.
DR InParanoid; Q8CIA9; -.
DR OMA; IRPVSWG; -.
DR OrthoDB; 763423at2759; -.
DR PhylomeDB; Q8CIA9; -.
DR TreeFam; TF313511; -.
DR BioGRID-ORCS; 66631; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Mfsd14b; mouse.
DR PRO; PR:Q8CIA9; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q8CIA9; protein.
DR Bgee; ENSMUSG00000038212; Expressed in granulocyte and 248 other tissues.
DR Genevisible; Q8CIA9; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR InterPro; IPR001958; Tet-R_TetA/multi-R_MdtG.
DR Pfam; PF07690; MFS_1; 1.
DR PRINTS; PR01035; TCRTETA.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..507
FT /note="Hippocampus abundant transcript-like protein 1"
FT /id="PRO_0000239230"
FT TOPO_DOM 1..51
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 73..84
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 106..113
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 135..136
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..170
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 192..198
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..257
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 279..283
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..304
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 305..323
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 324..344
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 345..347
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 348..368
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 369..389
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 390..410
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 411..430
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 431..451
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 452..507
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 459..483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 459..475
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 464
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 465
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 507 AA; 55087 MW; F301D4EEFC0699B9 CRC64;
MSTDGESPEE PRWKAVASPK ASTMPEKRGS AQAASGSWLQ GFGHPSVYHA AFVIFLEFFA
WGLLTTPMLT VLHETFPQHT FLMNGLIQGV KGLLSFLSAP LIGALSDVWG RKPFLLGTVF
FTCFPIPLMR INPWWYFGMI SVSGVFSVTF SVIFAYVADF TQEHERSTAY GWVSATFAAS
LVSSPAIGTY LSANYGDSLV VLVATLVALL DICFILIAVP ESLSEKIRPA SWGAQISWKQ
ADPFASLKKV GKDSTVLLIC ITVFLSYLPE AGQYSSFFLY LRQVIGFGSV KIVAFIAMVG
ILSIVAQTVF LSKLMRSLGN KNTVLLGLGF QMLQLAWYGF GSQAWMMWAA GTVAAMSSIT
FPAVSALISR NAESDQQGVA QGIVTGIRGL CNGLGPALYG FIFYMFHVEL SELGPKLNSD
DDPLQGAFIP GPPFLFGACI VLMSFLVALF IPEYRKTSGV QKHNNSTSGS LSTPPERGSD
EDIEPLLQDS SIWELSFEEP GNQCTEL
