MF14B_RAT
ID MF14B_RAT Reviewed; 507 AA.
AC B2RYH9;
DT 26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Hippocampus abundant transcript-like protein 1 {ECO:0000250|UniProtKB:Q5SR56};
DE AltName: Full=Major facilitator superfamily domain-containing 14B {ECO:0000312|RGD:1308377};
GN Name=Mfsd14b {ECO:0000312|RGD:1308377};
GN Synonyms=Hiatl1 {ECO:0000250|UniProtKB:Q5SR56};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
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DR EMBL; CH474087; EDL84449.1; -; Genomic_DNA.
DR EMBL; BC166784; AAI66784.1; -; mRNA.
DR RefSeq; NP_001100804.1; NM_001107334.1.
DR AlphaFoldDB; B2RYH9; -.
DR SMR; B2RYH9; -.
DR STRING; 10116.ENSRNOP00000060101; -.
DR GlyGen; B2RYH9; 1 site.
DR PaxDb; B2RYH9; -.
DR PeptideAtlas; B2RYH9; -.
DR Ensembl; ENSRNOT00000067979; ENSRNOP00000060101; ENSRNOG00000018227.
DR GeneID; 306687; -.
DR KEGG; rno:306687; -.
DR UCSC; RGD:1308377; rat.
DR CTD; 84641; -.
DR RGD; 1308377; Mfsd14b.
DR eggNOG; KOG2816; Eukaryota.
DR GeneTree; ENSGT00940000156081; -.
DR HOGENOM; CLU_001265_10_5_1; -.
DR InParanoid; B2RYH9; -.
DR OMA; IRPVSWG; -.
DR OrthoDB; 763423at2759; -.
DR PhylomeDB; B2RYH9; -.
DR PRO; PR:B2RYH9; -.
DR Proteomes; UP000002494; Chromosome 17.
DR Proteomes; UP000234681; Chromosome 17.
DR Bgee; ENSRNOG00000018227; Expressed in jejunum and 19 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR InterPro; IPR001958; Tet-R_TetA/multi-R_MdtG.
DR Pfam; PF07690; MFS_1; 1.
DR PRINTS; PR01035; TCRTETA.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..507
FT /note="Hippocampus abundant transcript-like protein 1"
FT /id="PRO_0000375849"
FT TOPO_DOM 1..51
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 73..84
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 106..113
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 135..136
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..170
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 192..198
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..257
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 279..283
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..304
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 305..323
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 324..344
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 345..347
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 348..368
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 369..389
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 390..410
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 411..430
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 431..451
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 452..507
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 462..483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 464
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 507 AA; 54936 MW; CB6957071C1F6FE1 CRC64;
MSTDGESPEE PGWKAVASPK ASAMPEKRGS AQAASSSWLQ GFGQPSVYHA AFVIFFEFFA
WGLLTTPMLT VLHETFPQHT FLMNGLIQGV KGLLSFLSAP LIGALSDVWG RKPFLLGTVF
FTCFPIPLMR ISPWWYFGMI SVSGVFSVTF SVIFAYVADF TQEHERSTAY GWVSATFAAS
LVSSPAIGTY LSSNYGDSLV VLVATVVALL DICFILVAVP ESLPEKIRPA SWGAQISWKQ
ADPFASLKKV GKDSTVLLIC ITVFLSYLPE AGQYSSFFLY LRQVIGFGSV KIVAFIAMVG
ILSILAQTVF LSKLMRSLGN KNTVLLGLGF QILQLAWYGF GAQAWMMWAA GTVAAMSSIT
FPAVSALISR NAESDQQGVA QGIITGIRGL CNGLGPALYG FIFYLFHVEL NELGPKLDSD
NDPLQGAFIP GPPFLFGACI VLMSFLVALF IPEYRKTGGV QKHNNSISGS LSTPPERGSD
EDIEPLLQDS NIWELSSEEP GNQCTEL
