MF14C_HUMAN
ID MF14C_HUMAN Reviewed; 150 AA.
AC Q5VZR4; Q9BSG7; R4GN14;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-NOV-2018, sequence version 2.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Hippocampus abundant transcript-like protein 2 {ECO:0000312|HGNC:HGNC:23672};
DE AltName: Full=Major facilitator superfamily domain-containing 14C {ECO:0000312|HGNC:HGNC:23672};
GN Name=MFSD14C {ECO:0000312|HGNC:HGNC:23672};
GN Synonyms=HIATL2 {ECO:0000312|HGNC:HGNC:23672};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q5VZR4; Q6NTF9-3: RHBDD2; NbExp=3; IntAct=EBI-2867865, EBI-17589229;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
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DR EMBL; AL158827; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL445670; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC005058; -; NOT_ANNOTATED_CDS; mRNA.
DR AlphaFoldDB; Q5VZR4; -.
DR SMR; Q5VZR4; -.
DR IntAct; Q5VZR4; 2.
DR iPTMnet; Q5VZR4; -.
DR PhosphoSitePlus; Q5VZR4; -.
DR BioMuta; MFSD14C; -.
DR jPOST; Q5VZR4; -.
DR MassIVE; Q5VZR4; -.
DR PaxDb; Q5VZR4; -.
DR PeptideAtlas; Q5VZR4; -.
DR PRIDE; Q5VZR4; -.
DR UCSC; uc064upl.1; human.
DR GeneCards; MFSD14C; -.
DR HGNC; HGNC:23672; MFSD14C.
DR neXtProt; NX_Q5VZR4; -.
DR eggNOG; KOG2816; Eukaryota.
DR HOGENOM; CLU_159679_0_0_1; -.
DR InParanoid; Q5VZR4; -.
DR PhylomeDB; Q5VZR4; -.
DR PathwayCommons; Q5VZR4; -.
DR SignaLink; Q5VZR4; -.
DR ChiTaRS; MFSD14C; human.
DR Pharos; Q5VZR4; Tdark.
DR PRO; PR:Q5VZR4; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q5VZR4; protein.
DR Genevisible; Q5VZR4; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..150
FT /note="Hippocampus abundant transcript-like protein 2"
FT /id="PRO_0000239231"
FT TOPO_DOM 1..49
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 71..82
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 83..103
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 104..111
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 133..150
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 150 AA; 16372 MW; 35EC9A298EE14B04 CRC64;
MSVEPPPELE EKAASEPEAG AMPEKRAGAQ AAGSTWLQGF GPPSVYHAAI VIFLEFFAWG
LLTTPMLTVL HETFSQHTFL MNGLIQGVKG LLSFLSAPLI GALSDVWGRK PFLLGTVFFT
CFPIPLMRIS PCRVWWRAPV VPATCGRRMA
