MF4B1_MOUSE
ID MF4B1_MOUSE Reviewed; 425 AA.
AC Q8VCV9;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 2.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Sodium-dependent glucose transporter 1A {ECO:0000250|UniProtKB:Q80T22};
DE AltName: Full=Major facilitator superfamily domain-containing protein 4B1;
GN Name=Mfsd4b1 {ECO:0000312|MGI:MGI:2143575}; Synonyms=Naglt1a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May function as a sodium-dependent glucose transporter.
CC Potential channels for urea in the inner medulla of kidney.
CC {ECO:0000250|UniProtKB:Q80T22}.
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000250|UniProtKB:Q80T22}; Multi-pass membrane protein
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH18406.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC41015.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK089961; BAC41015.1; ALT_INIT; mRNA.
DR EMBL; BC018406; AAH18406.1; ALT_INIT; mRNA.
DR CCDS; CCDS35884.2; -.
DR RefSeq; NP_659070.2; NM_144821.4.
DR AlphaFoldDB; Q8VCV9; -.
DR SMR; Q8VCV9; -.
DR STRING; 10090.ENSMUSP00000128324; -.
DR iPTMnet; Q8VCV9; -.
DR PhosphoSitePlus; Q8VCV9; -.
DR jPOST; Q8VCV9; -.
DR PaxDb; Q8VCV9; -.
DR PRIDE; Q8VCV9; -.
DR ProteomicsDB; 295891; -.
DR DNASU; 215929; -.
DR Ensembl; ENSMUST00000163705; ENSMUSP00000128324; ENSMUSG00000038522.
DR GeneID; 215929; -.
DR KEGG; mmu:215929; -.
DR UCSC; uc007ewl.2; mouse.
DR CTD; 215929; -.
DR MGI; MGI:2143575; Mfsd4b1.
DR VEuPathDB; HostDB:ENSMUSG00000038522; -.
DR eggNOG; ENOG502R5UW; Eukaryota.
DR GeneTree; ENSGT00530000063320; -.
DR HOGENOM; CLU_028923_1_0_1; -.
DR InParanoid; Q8VCV9; -.
DR OMA; ALGDMAI; -.
DR OrthoDB; 1122917at2759; -.
DR PhylomeDB; Q8VCV9; -.
DR TreeFam; TF314613; -.
DR BioGRID-ORCS; 215929; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Mfsd4b1; mouse.
DR PRO; PR:Q8VCV9; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q8VCV9; protein.
DR Bgee; ENSMUSG00000038522; Expressed in right kidney and 67 other tissues.
DR Genevisible; Q8VCV9; MM.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005355; F:glucose transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Ion transport; Membrane; Reference proteome; Sodium;
KW Sodium transport; Sugar transport; Symport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..425
FT /note="Sodium-dependent glucose transporter 1A"
FT /id="PRO_0000294511"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 228..248
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 294..314
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 320..340
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 355..375
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 382..402
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 27
FT /note="N -> H (in Ref. 1; BAC41015)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 425 AA; 45686 MW; E9CE984A95917EB6 CRC64;
MYAAFLGLGM SVAILGPTFQ DLAENVNRNI SSLSLIFVGR ATGFLSGTMI GGVLFDHINQ
FFLLGASMVA TAAGLYLIPF CKTAVLLIIT MSVFGASVGV VDTGANVLIL DLWGDKGAPQ
MQALHFSFAL GAFLAPLLAK LAWGTAPAQN HTESDLDTLM LNRSSNGTSD SVFAVPDDMN
LLWAYASIGT FILVVSVFLF GLFCKKHSRQ KKPRASAEGA RRAKYHRALL CLLFLFFFFY
VGAEITYGSY IFSFATTHVG MEESEAAGLN SIFWGTFAAC RGLAIFFATF LQPGTMIVLS
NIGSLVSCFF LVLFDKSPLC LWIATSVYGA SMAATFPSGI SWIEQYTTLT GKSAAFFVIG
SALGDMAIPA VIGILQGHYP DLPVVLYTCL GSAIFTAILF PVMYKLATLP LKREDQKALP
TSSRL
