ID   MFA1_SACUV              Reviewed;         144 AA.
AC   P25501;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Mating factor alpha;
DE   AltName: Full=Alpha mating pheromone;
DE   Contains:
DE     RecName: Full=Alpha-1 mating pheromone;
DE   Contains:
DE     RecName: Full=Mating factor alpha;
DE   Flags: Precursor;
OS   Saccharomyces uvarum (Yeast) (Saccharomyces bayanus var. uvarum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=230603;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 10596 / NBRC 0751 / NRRL Y-379;
RX   PubMed=2834101; DOI=10.1007/bf00365748;
RA   Kitada K., Hishinuma F.;
RT   "Evidence for preferential multiplication of the internal unit in tandem
RT   repeats of the mating factor alpha genes in Saccharomyces yeasts.";
RL   Curr. Genet. 13:1-5(1988).
CC   -!- FUNCTION: The active factor is excreted into the culture medium by
CC       haploid cells of the alpha mating type and acts on cells of the
CC       opposite mating type (type A). It mediates the conjugation process
CC       between the two types by inhibiting the initiation of DNA synthesis in
CC       type a cells and synchronizing them with type alpha.
CC   -!- DOMAIN: The mating factor alpha-1 precursor is identical in S.italicus,
CC       S.uvarum and S.cerevisiae, except for the number of tandem repeat
CC       units: 5, 3 and 4 respectively.
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DR   EMBL; M55013; AAA34813.1; -; Genomic_DNA.
DR   AlphaFoldDB; P25501; -.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0000772; F:mating pheromone activity; IEA:InterPro.
DR   GO; GO:0007618; P:mating; IEA:InterPro.
DR   GO; GO:0000750; P:pheromone-dependent signal transduction involved in conjugation with cellular fusion; IEA:InterPro.
DR   InterPro; IPR016326; Mating_factor_a.
DR   InterPro; IPR006742; Mating_factor_alpha_C.
DR   InterPro; IPR008675; Mating_factor_alpha_N.
DR   Pfam; PF04648; MF_alpha; 3.
DR   Pfam; PF05436; MF_alpha_N; 1.
DR   PIRSF; PIRSF001866; Mating_factor_alpha; 1.
PE   4: Predicted;
KW   Cleavage on pair of basic residues; Pheromone; Repeat; Signal.
FT   SIGNAL          1..19
FT                   /note="Or 20"
FT                   /evidence="ECO:0000305"
FT   CHAIN           20..144
FT                   /note="Alpha-1 mating pheromone"
FT                   /id="PRO_0000021686"
FT   PEPTIDE         90..102
FT                   /note="Mating factor alpha"
FT                   /id="PRO_0000021687"
FT   PEPTIDE         111..123
FT                   /note="Mating factor alpha"
FT                   /id="PRO_0000021688"
FT   PEPTIDE         132..144
FT                   /note="Mating factor alpha"
FT                   /id="PRO_0000021689"
SQ   SEQUENCE   144 AA;  16091 MW;  97E3C2B8AA98F996 CRC64;
     MRFPSIFTAV LFAASSALAA PVNTTTEDET AQIPAEAVIG YLDLEGDFDV AVLPFSNSTN
     NGLLFINTTI ASIAAKEEGV SLDKREAEAW HWLQLKPGQP MYKREADAEA WHWLQLKPGQ
     PMYKREADAE AWHWLQLKPG QPMY