ID   MFA1_USTMA              Reviewed;          40 AA.
AC   P31962; A0A0D1E0Y9; Q4PBY1;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=A1-specific pheromone;
DE   AltName: Full=Mating factor A1;
DE   Flags: Precursor;
GN   Name=MFA1; ORFNames=UMAG_02382;
OS   Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC   Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX   NCBI_TaxID=237631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1310895; DOI=10.1016/0092-8674(92)90182-c;
RA   Boelker M., Urban M., Kahmann R.;
RT   "The a mating type locus of U. maydis specifies cell signaling
RT   components.";
RL   Cell 68:441-450(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8602158; DOI=10.1007/bf02174029;
RA   Urban M., Kahmann R., Boelker M.;
RT   "The biallelic a mating type locus of Ustilago maydis: remnants of an
RT   additional pheromone gene indicate evolution from a multiallelic
RT   ancestor.";
RL   Mol. Gen. Genet. 250:414-420(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=521 / FGSC 9021;
RX   PubMed=17080091; DOI=10.1038/nature05248;
RA   Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J.,
RA   Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H.,
RA   Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G.,
RA   Snetselaar K., McCann M., Perez-Martin J., Feldbruegge M., Basse C.W.,
RA   Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L.,
RA   Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L.,
RA   Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N.,
RA   Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B.,
RA   Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J.,
RA   Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P.,
RA   Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G.,
RA   Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A.,
RA   Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M.,
RA   Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M.,
RA   Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E.,
RA   Birren B.W.;
RT   "Insights from the genome of the biotrophic fungal plant pathogen Ustilago
RT   maydis.";
RL   Nature 444:97-101(2006).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=521 / FGSC 9021;
RA   Gueldener U., Muensterkoetter M., Walter M.C., Mannhaupt G., Kahmann R.;
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mating pheromone for A1 allele.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
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DR   EMBL; M84159; AAA34227.1; -; Genomic_DNA.
DR   EMBL; U37795; AAA99765.1; -; Genomic_DNA.
DR   EMBL; CM003144; KIS69864.1; -; Genomic_DNA.
DR   PIR; A42087; A42087.
DR   RefSeq; XP_011388682.1; XM_011390380.1.
DR   AlphaFoldDB; P31962; -.
DR   EnsemblFungi; KIS69864; KIS69864; UMAG_02382.
DR   GeneID; 23563141; -.
DR   KEGG; uma:UMAG_02382; -.
DR   VEuPathDB; FungiDB:UMAG_02382; -.
DR   HOGENOM; CLU_218871_0_0_1; -.
DR   Proteomes; UP000000561; Chromosome 5.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005186; F:pheromone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR035382; MFA1.
DR   Pfam; PF17445; Mfa1; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Lipoprotein; Membrane; Methylation; Pheromone; Prenylation;
KW   Reference proteome.
FT   PEPTIDE         1..37
FT                   /note="A1-specific pheromone"
FT                   /id="PRO_0000044779"
FT   PROPEP          38..40
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000403474"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..31
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         37
FT                   /note="Cysteine methyl ester"
FT                   /evidence="ECO:0000255"
FT   LIPID           37
FT                   /note="S-farnesyl cysteine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   40 AA;  4113 MW;  62D3099702F48EC5 CRC64;
     MLSIFAQTTQ TSASEPQQSP TAPQGRDNGS PIGYSSCVVA