ID   MFAP1_DICDI             Reviewed;         460 AA.
AC   Q54SU3;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Protein MFAP1 homolog;
GN   Name=mfap1; ORFNames=DDB_G0282219;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Involved in pre-mRNA splicing as a component of the
CC       spliceosome. {ECO:0000250|UniProtKB:P55081}.
CC   -!- SUBUNIT: Component of the spliceosome B complex.
CC       {ECO:0000250|UniProtKB:P55081}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P55081}.
CC   -!- SIMILARITY: Belongs to the MFAP1 family. {ECO:0000305}.
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DR   EMBL; AAFI02000046; EAL66315.1; -; Genomic_DNA.
DR   RefSeq; XP_640292.1; XM_635200.1.
DR   AlphaFoldDB; Q54SU3; -.
DR   SMR; Q54SU3; -.
DR   STRING; 44689.DDB0233575; -.
DR   PaxDb; Q54SU3; -.
DR   PRIDE; Q54SU3; -.
DR   EnsemblProtists; EAL66315; EAL66315; DDB_G0282219.
DR   GeneID; 8623468; -.
DR   KEGG; ddi:DDB_G0282219; -.
DR   dictyBase; DDB_G0282219; mfap1.
DR   eggNOG; KOG1425; Eukaryota.
DR   HOGENOM; CLU_023077_1_0_1; -.
DR   InParanoid; Q54SU3; -.
DR   OMA; FHNERAG; -.
DR   PRO; PR:Q54SU3; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005684; C:U2-type spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   InterPro; IPR033194; MFAP1.
DR   InterPro; IPR009730; MFAP1_C.
DR   PANTHER; PTHR15327; PTHR15327; 1.
DR   Pfam; PF06991; MFAP1; 1.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Spliceosome.
FT   CHAIN           1..460
FT                   /note="Protein MFAP1 homolog"
FT                   /id="PRO_0000333272"
FT   REGION          1..291
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          411..460
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        36..52
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        63..105
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        119..186
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        187..208
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        216..275
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        420..449
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   460 AA;  55118 MW;  FBAB15BC9BD34068 CRC64;
     MSVASRIRDK LKNNLESSGG HSVVTSGTKV IRYRAGQRPD YAEAEDDQDS HFSNIQNQKS
     IKEAETNDPR LARFKNRSSN QDEPQSVEER KASRRRHHDD DNDNDTTTTT TTTTSRRIQK
     TEIIKEDDDN NNNNNNDTKK DHNDDDEDDD RRRRAKERYL KKKEEEEQKQ KELEEKQQPF
     KDIEGESEEE GSSEYETDSE EDDEDEYWDQ PPIFRPTFIK KDDRGTIKTD EQWEKEEQEQ
     QAQLEREKEQ RKIEAHRKLK DELDRDRKEQ EAKELEQKEE EEYDDDEDQD GSKKLLWIQR
     ELERVRLEIH TRLLAEFEKK EFARRRAMTD DQILKEDPSR SRTNIDNSQK KQLKFLQRDY
     HRGAFFQDDE YIKNKDFSAP TGEDKFNREL LPKVMQVKNF GKAGRTKYTH LKDQDTTEKD
     SLWNTNYNNK KKYNNNNNNS NSNSSNNNRD YNYRDRDNRS