ID   MFAP3_PONAB             Reviewed;         362 AA.
AC   Q5R9E4;
DT   21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Microfibril-associated glycoprotein 3;
DE   Flags: Precursor;
GN   Name=MFAP3;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the elastin-associated microfibrils.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- PTM: Glycosylated. {ECO:0000305}.
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DR   EMBL; CR859445; CAH91616.1; -; mRNA.
DR   RefSeq; NP_001125952.1; NM_001132480.1.
DR   AlphaFoldDB; Q5R9E4; -.
DR   STRING; 9601.ENSPPYP00000017873; -.
DR   Ensembl; ENSPPYT00000018589; ENSPPYP00000017873; ENSPPYG00000015972.
DR   GeneID; 100172887; -.
DR   KEGG; pon:100172887; -.
DR   CTD; 4238; -.
DR   eggNOG; ENOG502QW9J; Eukaryota.
DR   GeneTree; ENSGT00390000011576; -.
DR   HOGENOM; CLU_056017_0_0_1; -.
DR   InParanoid; Q5R9E4; -.
DR   OMA; KPHCCLF; -.
DR   OrthoDB; 1154642at2759; -.
DR   TreeFam; TF333205; -.
DR   Proteomes; UP000001595; Chromosome 5.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013151; Immunoglobulin.
DR   InterPro; IPR039696; MFAP3-like.
DR   PANTHER; PTHR14340; PTHR14340; 1.
DR   Pfam; PF00047; ig; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW   Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..362
FT                   /note="Microfibril-associated glycoprotein 3"
FT                   /id="PRO_0000014867"
FT   TOPO_DOM        20..146
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        168..362
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          45..137
FT                   /note="Ig-like C2-type"
FT   REGION          282..306
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          319..362
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        36
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        41
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        110
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        73..124
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   362 AA;  40106 MW;  E01C8E07A3D1D142 CRC64;
     MKLHCCLFTL VASIIVPAAF VLEDVDFNQM VSLEANRSSY NASFPSSFEL SASSHSDDDV
     IIAKEGTSVS IECLLTASHY EDVHWHNSKG QQLDGRGRGG KWLVSDNFLN ITNVAFDDRG
     LYTCFVTSPI RASYSVTLRV IFTSGDMSVY YMIVCLIAFT ITLILNVTRL CMMSSHLRKT
     EKAINEFFRT EGAEKLQKAF EIAKRIPIIT SAKTLELAKV TQFKTMEFAR YIEELARSVP
     LPPLILNCRA FVEEMFEAVR VDDPDDLGER IKERPALNAQ GGIYVINPEM GRSNSPGGDS
     DDGSLNEQGQ EIAVQVSVHL QSETKSIDTE SQGSSHFSPP DDTGSAESNC NYKDGAYENS
     QL