ID   MFAP3_RAT               Reviewed;         347 AA.
AC   Q6AYF7;
DT   21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Microfibril-associated glycoprotein 3;
DE   Flags: Precursor;
GN   Name=Mfap3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Component of the elastin-associated microfibrils.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- PTM: Glycosylated. {ECO:0000305}.
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DR   EMBL; BC079064; AAH79064.1; -; mRNA.
DR   RefSeq; NP_001007610.1; NM_001007609.1.
DR   RefSeq; XP_006246441.1; XM_006246379.2.
DR   AlphaFoldDB; Q6AYF7; -.
DR   BioGRID; 252088; 1.
DR   STRING; 10116.ENSRNOP00000003361; -.
DR   GlyGen; Q6AYF7; 4 sites.
DR   iPTMnet; Q6AYF7; -.
DR   PhosphoSitePlus; Q6AYF7; -.
DR   SwissPalm; Q6AYF7; -.
DR   PaxDb; Q6AYF7; -.
DR   Ensembl; ENSRNOT00000003361; ENSRNOP00000003361; ENSRNOG00000002443.
DR   GeneID; 287299; -.
DR   KEGG; rno:287299; -.
DR   UCSC; RGD:1359463; rat.
DR   CTD; 4238; -.
DR   RGD; 1359463; Mfap3.
DR   eggNOG; ENOG502QW9J; Eukaryota.
DR   GeneTree; ENSGT00390000011576; -.
DR   HOGENOM; CLU_056017_0_0_1; -.
DR   InParanoid; Q6AYF7; -.
DR   OMA; KPHCCLF; -.
DR   OrthoDB; 1154642at2759; -.
DR   PhylomeDB; Q6AYF7; -.
DR   TreeFam; TF333205; -.
DR   Reactome; R-RNO-2129379; Molecules associated with elastic fibres.
DR   PRO; PR:Q6AYF7; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000002443; Expressed in jejunum and 19 other tissues.
DR   Genevisible; Q6AYF7; RN.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013151; Immunoglobulin.
DR   InterPro; IPR039696; MFAP3-like.
DR   PANTHER; PTHR14340; PTHR14340; 1.
DR   Pfam; PF00047; ig; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW   Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..347
FT                   /note="Microfibril-associated glycoprotein 3"
FT                   /id="PRO_0000014868"
FT   TOPO_DOM        23..139
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        161..347
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          47..130
FT                   /note="Ig-like C2-type"
FT   REGION          280..347
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        286..338
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        31
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        36
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        63
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        103
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        68..117
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   347 AA;  38397 MW;  150B07C643547EE0 CRC64;
     MKLHYCLCIL LVVTFVPTAL VLEDVTPLGT NQSSYNASFL SSFELSAGSY SGDDVIIAKE
     GTNVSLECLL TVDHYGEVHW YNSKGRQLHS RGGKWLVSDN FLNITSVAFD DRGLYTCIIT
     SPTRASYSVT LRVIFTSGDM SVYYMVVCLI AFTITLILNV TRLCLMSTHL RKTEKAINEF
     FRTEGAEKLQ KAFEIAKRIP IITSAKTLEL AKVTQFKTME FARYIEELAR SVPLPPLILN
     CRAFVEEMFE AVRVDDPDDM GERIKERPAL DAQSGIYVIN PELGRSNSPG GDSDDGSLSE
     QGQEIAVQVS VHLQSETKSI GTDSQDSSHF SPPSDPASAE GSTHHRE