MFC1_SCHPO
ID MFC1_SCHPO Reviewed; 495 AA.
AC Q9HDX4; Q9C0Y3;
DT 29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 29-MAR-2004, sequence version 2.
DT 25-MAY-2022, entry version 108.
DE RecName: Full=Uncharacterized transporter mfc1;
GN Name=mfc1; ORFNames=SPAPB1A11.01, SPAPB24D3.11;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP DISRUPTION PHENOTYPE.
RX PubMed=20537132; DOI=10.1186/gb-2010-11-6-r60;
RA Han T.X., Xu X.Y., Zhang M.J., Peng X., Du L.L.;
RT "Global fitness profiling of fission yeast deletion strains by barcode
RT sequencing.";
RL Genome Biol. 11:R60.1-R60.13(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- DISRUPTION PHENOTYPE: Lead to sensitivity to camptothecin and DNA
CC damaging agents. {ECO:0000269|PubMed:20537132}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. CAR1 family.
CC {ECO:0000305}.
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DR EMBL; CU329670; CAC36907.1; -; Genomic_DNA.
DR RefSeq; XP_001713075.1; XM_001713023.2.
DR AlphaFoldDB; Q9HDX4; -.
DR BioGRID; 280556; 1.
DR STRING; 4896.SPAPB1A11.01.1; -.
DR TCDB; 2.A.1.2.76; the major facilitator superfamily (mfs).
DR PaxDb; Q9HDX4; -.
DR EnsemblFungi; SPAPB1A11.01.1; SPAPB1A11.01.1:pep; SPAPB1A11.01.
DR PomBase; SPAPB1A11.01; mfc1.
DR VEuPathDB; FungiDB:SPAPB1A11.01; -.
DR eggNOG; KOG0255; Eukaryota.
DR HOGENOM; CLU_008455_1_1_1; -.
DR InParanoid; Q9HDX4; -.
DR OMA; YSIYTNM; -.
DR PhylomeDB; Q9HDX4; -.
DR PRO; PR:Q9HDX4; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005628; C:prospore membrane; IDA:PomBase.
DR GO; GO:0005375; F:copper ion transmembrane transporter activity; IMP:PomBase.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0097430; P:copper ion import across prospore membrane; IMP:PomBase.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..495
FT /note="Uncharacterized transporter mfc1"
FT /id="PRO_0000173447"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..304
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 323..343
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 366..386
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 390..410
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 426..446
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 461..481
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 495 AA; 55307 MW; 49C4EF37982421DE CRC64;
MSVSDKDFKD IELLPVKSIE SKDSIDQCDP LTWPIRIRII NTIIISFMTM LCMYGSSVFM
PSIPELCEKF GEPETLVVLG ATLYVIGVML GPLIFSPLSE LYGRRPLNIF GYTLFALMQI
PTALSVNLAM FVVFRFFSGF FGSVGLGIGA GSLSDMFSKR DRGKYIGIYF LGICLGPAIA
PIASGFIAGS SISWRWEFWI LLMLSGVSLL AGVVFLKETY APVLKRKQAK KLLEKQENQK
SVEVKISEIT ESSQQIDPDK SFAEVVHILV TTIRRPLHLL CTQPIMILIS LIVGTVYGIL
YLLFTAFAEV WISQYHFTSG LSGLTYISLS IGQVFAVFVL LPLNQKYWLS AVQKNNGVPE
PEFRLPMAFL GCFAIMTGMF IFGWTVQYKV FWFVPLIGTT LVGAGFVMTF NPMNMFIVDN
YGRYAASAMA AIAIPRNIFG ACFPLFAEKL FERLGYGWGS SLLAFLLVAI NFSIAALYMF
GKTIREKRPF DHTKY
