ID   MFD4A_DANRE             Reviewed;         526 AA.
AC   Q7SXB7;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Major facilitator superfamily domain-containing protein 4A;
GN   Name=mfsd4a; Synonyms=mfsd4; ORFNames=zgc:66461;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC055671; AAH55671.1; -; mRNA.
DR   RefSeq; NP_956825.1; NM_200531.1.
DR   AlphaFoldDB; Q7SXB7; -.
DR   STRING; 7955.ENSDARP00000032062; -.
DR   TCDB; 2.A.1.7.15; the major facilitator superfamily (mfs).
DR   PaxDb; Q7SXB7; -.
DR   GeneID; 393503; -.
DR   KEGG; dre:393503; -.
DR   CTD; 393503; -.
DR   ZFIN; ZDB-GENE-040426-1643; mfsd4aa.
DR   eggNOG; ENOG502QRVK; Eukaryota.
DR   InParanoid; Q7SXB7; -.
DR   OrthoDB; 952222at2759; -.
DR   PhylomeDB; Q7SXB7; -.
DR   PRO; PR:Q7SXB7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005355; F:glucose transmembrane transporter activity; IBA:GO_Central.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..526
FT                   /note="Major facilitator superfamily domain-containing
FT                   protein 4A"
FT                   /id="PRO_0000273398"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        215..235
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        297..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        341..361
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        377..397
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        401..421
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        430..450
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        458..478
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   526 AA;  57549 MW;  1122B5C51A98C248 CRC64;
     MTYLLNERIC ALFRSNWQHT LTYWSVFFSF GLCVAFLGPT ILDLRCQTQS TLQEITLVFF
     SQQFFLFLGS TIGGFFSKTL VSSLSSLAVS TLIISVVFAI IPLCRELLML AFAMAVSGLA
     MGTIDTISNL QLVKIYQKDS TVFLQALHFF VGLGALVSPL IADPFLSDTS CVIGNSSVNT
     TSLEDLRNKL AGRHVHNVSN VHLHTDGEVV TNVSYAFWIM AIINLPVPIA IFVLVYRERL
     FMCGSDPSRR LLDGDVLAIK PRGTSILAED TGQKETSNSH ADLFSCCLLG KAHSFPLSFF
     GIHVLGGLVL FFSDGIVGSY TGFVYTYAVA PPMNLPHKTA GYLTCIFWAA ITTGRLSAIP
     LSYRFKPVRL LIVSQVGVIV TVLLLLIFSN SSVFLFIGTC CLGLFISSIF PCMLALTEDI
     LEYKGCATTV LVTSAGMGEM VLQVLVGSVM HSRGSFSFLL CGMIFGCLGF TFFTFLYFVQ
     QSHKSYTEAL PGNSPVERHE ENGIKTCSAA VLNSWDAPEH KTSLDP