ID   MFD4A_XENTR             Reviewed;         503 AA.
AC   Q5BIZ0;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Major facilitator superfamily domain-containing protein 4A;
DE   AltName: Full=Major facilitator superfamily domain-containing protein 4;
GN   Name=mfsd4a; Synonyms=mfsd4;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC091703; AAH91703.1; -; mRNA.
DR   RefSeq; NP_001025653.1; NM_001030482.1.
DR   AlphaFoldDB; Q5BIZ0; -.
DR   STRING; 8364.ENSXETP00000002145; -.
DR   PaxDb; Q5BIZ0; -.
DR   DNASU; 595041; -.
DR   Ensembl; ENSXETT00000002145; ENSXETP00000002145; ENSXETG00000000985.
DR   GeneID; 595041; -.
DR   KEGG; xtr:595041; -.
DR   CTD; 148808; -.
DR   Xenbase; XB-GENE-489846; mfsd4a.
DR   eggNOG; ENOG502QRVK; Eukaryota.
DR   HOGENOM; CLU_028923_0_0_1; -.
DR   InParanoid; Q5BIZ0; -.
DR   OMA; AMLMCNL; -.
DR   OrthoDB; 952222at2759; -.
DR   PhylomeDB; Q5BIZ0; -.
DR   TreeFam; TF314613; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000000985; Expressed in stomach and 7 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005355; F:glucose transmembrane transporter activity; IBA:GO_Central.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..503
FT                   /note="Major facilitator superfamily domain-containing
FT                   protein 4A"
FT                   /id="PRO_0000273399"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        214..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        289..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        338..358
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        366..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        392..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        427..447
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        455..475
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          484..503
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   503 AA;  55308 MW;  0F8AE459715A7B88 CRC64;
     MWLDERLLAL FRRNFQSTLT YWSVFFSFGL CIAFLGPTLL DLRCQTHSSL QDITWVFFAQ
     QFCLLVGSTL GGVFKRTVKQ SLFLLFLSSL TISVVFVIIP FCDHVGVLAL VMAIAGLAMG
     CIDTISNMQL VKIYQQDSAI FLQVLHFFVG FGALLSPLIA DPFLSDTNCI QSNATQNGSR
     NLEHIRNSLV PHHPRNVSHY VLPLQGALVT QVSYAFWIMA AINLPVPVAV FYLIYKKGMV
     PGCHIQNGGL LSADELAMEM HKENDSQKIE AHEEHGHAVS LLCCQNKKIW NAPFTFFAIH
     MCAAVTLFMT DGIVGEYSGF VYSYAVEQPL NLAHKTAGYL PSLFWAFITL GRLISIPVSY
     KMAPRSMLFI NLIGVTATFL FLLLSQNSTT GMFVGTALLG LWLSSVFPSM LAYTEDILNY
     KGCATTVLVT GAGMGEMVLQ ILVGSVMQTQ GSYSFLVCGI CLSSLAFTLY AVLLVVDSLH
     NRASEDSACK PPGLDGEATS YQS