ID   MFD4B_DANRE             Reviewed;         536 AA.
AC   A9JTG4;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Major facilitator superfamily domain-containing protein 4B {ECO:0000250|UniProtKB:Q7SXB7};
GN   Name=mfsd4b {ECO:0000312|ZFIN:ZDB-GENE-060810-38}; ORFNames=zgc:175151;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1] {ECO:0000312|EMBL:AAI55331.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney {ECO:0000312|EMBL:AAI55331.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000255}.
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DR   EMBL; BC155330; AAI55331.1; -; mRNA.
DR   RefSeq; NP_001107888.1; NM_001114416.1.
DR   AlphaFoldDB; A9JTG4; -.
DR   STRING; 7955.ENSDARP00000025673; -.
DR   PaxDb; A9JTG4; -.
DR   GeneID; 558146; -.
DR   KEGG; dre:558146; -.
DR   CTD; 558146; -.
DR   ZFIN; ZDB-GENE-060810-38; mfsd4ab.
DR   eggNOG; ENOG502QRVK; Eukaryota.
DR   InParanoid; A9JTG4; -.
DR   OrthoDB; 952222at2759; -.
DR   PhylomeDB; A9JTG4; -.
DR   PRO; PR:A9JTG4; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005355; F:glucose transmembrane transporter activity; IBA:GO_Central.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..536
FT                   /note="Major facilitator superfamily domain-containing
FT                   protein 4B"
FT                   /id="PRO_0000401131"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        297..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        341..361
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        366..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        391..411
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        428..448
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        456..476
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   536 AA;  58619 MW;  38A312C906B57560 CRC64;
     MLIEERLLTL FKRNCQHTLT YWSVFFSFGL SIAFLGPTIL DLKCRTGSTL QEITWVFFAQ
     QLCLLIGSSS GGAFTKTLFS ALLALFLSSL IISVVFSIIP LCYNVLLLAI AMAVSGLAMG
     IIDTIANIQL VSIYKKDSPI FLQALHFFIG LGALLSPLIA EPFISGHCLR SNSTENATEI
     IHHFRSSFRS PVNLPESSPL SGPVEERNVS YAFWIMALIN LPVPIAVFVL MYQEKLLPFC
     PNSSPRLLDK DELAMETKAP DNTEMAELDD EVFLHSGHGN IFSCCTDGAL RGLPVTFFLI
     HIFGGMVLFM TEGIMGVYAG FVYTYAVSPP MSLQSKMAGN LNCIFWAAIT AGRLVSIPLS
     YRFKTVHLLL TNMAGVIVTL LLLMILYTNR VFLFVGTTFL GLFISSVFPC LVAYTEDILE
     YRGCATTVLV TLSGMGEMTL QVLAGTLIQK KGSYSFLVCG LVIGCLGFIF LLSVILSNHF
     HRKITGASKK AEITDGPAAP APEKTAPEHK TAVIQPECIK CDFGLDHNGS KPAENT