ID   MFD6A_DANRE             Reviewed;         793 AA.
AC   Q1LUQ4;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Major facilitator superfamily domain-containing protein 6-A;
DE   AltName: Full=Macrophage MHC class I receptor 2 homolog A;
GN   Name=mfsd6a; Synonyms=mfsd6, mmr2; ORFNames=si:dkey-188p4.2;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. MFSD6 family.
CC       {ECO:0000305}.
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DR   EMBL; BX927260; CAK05334.1; -; Genomic_DNA.
DR   RefSeq; NP_001076525.1; NM_001083056.1.
DR   RefSeq; XP_005161736.1; XM_005161679.3.
DR   AlphaFoldDB; Q1LUQ4; -.
DR   STRING; 7955.ENSDARP00000063028; -.
DR   PaxDb; Q1LUQ4; -.
DR   Ensembl; ENSDART00000063029; ENSDARP00000063028; ENSDARG00000032318.
DR   GeneID; 100034426; -.
DR   KEGG; dre:100034426; -.
DR   CTD; 100034426; -.
DR   ZFIN; ZDB-GENE-050208-335; mfsd6a.
DR   eggNOG; KOG3762; Eukaryota.
DR   GeneTree; ENSGT00530000063599; -.
DR   HOGENOM; CLU_013133_2_0_1; -.
DR   InParanoid; Q1LUQ4; -.
DR   OMA; PKKAYVH; -.
DR   OrthoDB; 628784at2759; -.
DR   PhylomeDB; Q1LUQ4; -.
DR   TreeFam; TF314366; -.
DR   PRO; PR:Q1LUQ4; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 22.
DR   Bgee; ENSDARG00000032318; Expressed in intestine and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0042590; P:antigen processing and presentation of exogenous peptide antigen via MHC class I; IBA:GO_Central.
DR   Gene3D; 1.20.1250.20; -; 3.
DR   InterPro; IPR024989; MFS_assoc_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF12832; MFS_1_like; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..793
FT                   /note="Major facilitator superfamily domain-containing
FT                   protein 6-A"
FT                   /id="PRO_0000321943"
FT   TRANSMEM        75..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        134..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        297..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        340..360
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        380..400
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        461..481
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        489..509
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        555..575
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        590..610
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        616..636
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          28..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          170..195
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          239..288
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          412..434
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          674..699
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          734..793
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        29..53
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        747..793
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   793 AA;  88232 MW;  BE0E5BDD351F6E1D CRC64;
     MADDRVAILT EDEEELKRKH LERFDRLSLE IQSPSQPPEN DVPNDTAPTP SPQHELSCCE
     RLFLRVNRHL LVSKVFYLFF YAAYGSLHPL LALYYKQLGM NPTQSGLLVG IRYFIEFCSA
     PFWGIVADRY RKGKAVLLFS MLCWILFNAG IGIVKPPIMA CKEETIPTTT KVPTVHPTPS
     NETFFPNTSS TSQMRRRRDL IGQYPWRTIL SSGQSSGYIS EHRIKRDSNL SFTPAPEELA
     NTTQTNQTST TTQPKPSTSI STSTPSSTNT TSSSTTKSTT TNPNLPPPEY NMDQVNAIFL
     LILLVIIIGE FFSAPAITIV DTVTLHYLGP HRDRYGLQRM WGSLGWGLAM LCIGIWIDHT
     STNLIIGNME CIMKNYKNYH IAFIVFGVLM VIALIVATQF KFDVQHHDTN EGQEVGNQQE
     NVQPRGSPGT RSTDTPTIVQ AEEFHFWDLM RLLCGVQYST VLFVAWFMGF GYGFVFTFLY
     WHLQDLTGTT TLFGICSVLS HVSELAAYFT SHKFIELVGH IRVLYIGLAC NTARYLYISY
     LENAWTVLPM EVLQGITHAS VWAACISYLS AAVPPPLRTS AQGILQGLHL GLGRGCGAMV
     GGIFVNYFGV AETFRGIGMA SLVILLIFSL IMYITGQNEK KEDKMLAENI PIPSSPVPIA
     TIDLVQNTAD VAAPARPEPK LPARKTQHQQ EQEDLNKPAW VPSGSPWVSV ALLVYQIREM
     VLLAKARPTV EVQPLQGTDE VRSDSQEDQS PPVFSDAVQN ENTPSGLQDH SGSPTAQLDV
     PTRDTQPPSQ HIS