MFD6B_DANRE
ID MFD6B_DANRE Reviewed; 747 AA.
AC B0UYT5;
DT 05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Major facilitator superfamily domain-containing protein 6-B {ECO:0000250|UniProtKB:Q6ZSS7};
DE AltName: Full=Macrophage MHC class I receptor 2 homolog B {ECO:0000250|UniProtKB:Q6ZSS7};
GN Name=mfsd6b; ORFNames=si:dkey-42h23.5, zgc:92925;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. MFSD6 family.
CC {ECO:0000255}.
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DR EMBL; CR735121; CAQ14052.1; -; Genomic_DNA.
DR AlphaFoldDB; B0UYT5; -.
DR STRING; 7955.ENSDARP00000120762; -.
DR PaxDb; B0UYT5; -.
DR Ensembl; ENSDART00000135821; ENSDARP00000120762; ENSDARG00000054583.
DR ZFIN; ZDB-GENE-040912-84; mfsd6b.
DR eggNOG; KOG3762; Eukaryota.
DR GeneTree; ENSGT00530000063599; -.
DR HOGENOM; CLU_013133_2_0_1; -.
DR InParanoid; B0UYT5; -.
DR OMA; ANQHNPF; -.
DR PhylomeDB; B0UYT5; -.
DR TreeFam; TF314366; -.
DR PRO; PR:B0UYT5; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 9.
DR Bgee; ENSDARG00000054583; Expressed in caudal fin and 26 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0042590; P:antigen processing and presentation of exogenous peptide antigen via MHC class I; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR024989; MFS_assoc_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF12832; MFS_1_like; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..747
FT /note="Major facilitator superfamily domain-containing
FT protein 6-B"
FT /id="PRO_0000397912"
FT TRANSMEM 15..35
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 222..242
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 306..326
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 391..411
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 420..440
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 453..470
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 485..507
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 520..540
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 546..566
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 597..625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 652..747
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 607..621
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 652..703
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 747 AA; 82602 MW; 2D4A4B3FF6B27124 CRC64;
MLCSNRQSSL DFQDLLFFLL LCIWLFTPLA SCVLQAAGND TYPKWPTRWD PLFYRVLQCS
APFWGFVADR FKKGKAVLLF SVLCWVVFNC GIGFVKPAAM SCVSVDPTVQ SPVNFTNYTH
AGNHTRQRRY LTEDAYANPP LSQPILAAYR PHSRYIRSAN TNTTSAPFRN STVDISMASN
LTTMSPSATK VPLKSTSTME TQAITAKVKQ YIIIFNKEQV DTIFLLILLV IIIGEFFSAP
AVTIVDTVTL QYLGQNRDRY GLQRMWGSLG WGIAMLSVGI WIDNTHITIF IQGLGCVLPD
YKNYQIAFIV FGVLMTSALI VATQFHFDNR AYQSDEEEDK KEDVEIPQVI QEVSSPESSS
DDAPVCPETN PQHFPFKDLF RIICGVRYGT VLFVAWFMGF GYGFVFTFLF WHLEDLKGTT
TLFGICSVLS HISELAAYFI SHKLIELVGH IRVLYIGLAC NTARYLYISY LENAWIVLPM
EVLQGLTHAS VWAACISYLS AAVPPALRTS AQGILQGLHL GLGRGCGAML GGVFVNFFGA
AETFRGLGMA SLVTLLIFSL IQWLLGQNEE KKGAMLAENI PVPSSPVPIA TIDLVQNQST
SQPNSDSKSR KTRHQEEQED PNKPAWVVSA SPWVTIAFAL YQIRDMVAQT KNNDCQGQQE
RSEQQTSAAP PGDESTSSQP NASSSPVEYA FQGPASSAFV PQNTHPVRPV AEPPSSTEAK
EPVENSTPLP GHSKPLPAIT QTQPTTH
