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MFD_RICCN
ID   MFD_RICCN               Reviewed;        1122 AA.
AC   Q92H58;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Transcription-repair-coupling factor {ECO:0000255|HAMAP-Rule:MF_00969};
DE            Short=TRCF {ECO:0000255|HAMAP-Rule:MF_00969};
DE            EC=3.6.4.- {ECO:0000255|HAMAP-Rule:MF_00969};
GN   Name=mfd {ECO:0000255|HAMAP-Rule:MF_00969}; OrderedLocusNames=RC0913;
OS   Rickettsia conorii (strain ATCC VR-613 / Malish 7).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=272944;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-613 / Malish 7;
RX   PubMed=11557893; DOI=10.1126/science.1061471;
RA   Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V.,
RA   Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.;
RT   "Mechanisms of evolution in Rickettsia conorii and R. prowazekii.";
RL   Science 293:2093-2098(2001).
CC   -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC       polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC       release of RNAP and its truncated transcript from the DNA, and
CC       recruitment of nucleotide excision repair machinery to the damaged
CC       site. {ECO:0000255|HAMAP-Rule:MF_00969}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00969}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00969}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC       RecG subfamily. {ECO:0000255|HAMAP-Rule:MF_00969}.
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DR   EMBL; AE006914; AAL03451.1; -; Genomic_DNA.
DR   PIR; A97814; A97814.
DR   RefSeq; WP_010977513.1; NC_003103.1.
DR   AlphaFoldDB; Q92H58; -.
DR   SMR; Q92H58; -.
DR   EnsemblBacteria; AAL03451; AAL03451; RC0913.
DR   KEGG; rco:RC0913; -.
DR   PATRIC; fig|272944.4.peg.1038; -.
DR   HOGENOM; CLU_005122_3_2_5; -.
DR   OMA; SHVVHIN; -.
DR   Proteomes; UP000000816; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.300; -; 2.
DR   Gene3D; 3.90.1150.50; -; 1.
DR   HAMAP; MF_00969; TRCF; 1.
DR   InterPro; IPR036101; CarD-like/TRCF_dom_sf.
DR   InterPro; IPR003711; CarD-like/TRCF_domain.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR004576; Mfd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR037235; TRCF-like_C_D7.
DR   InterPro; IPR005118; TRCF_C.
DR   InterPro; IPR041471; UvrB_inter.
DR   Pfam; PF02559; CarD_CdnL_TRCF; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF03461; TRCF; 1.
DR   Pfam; PF17757; UvrB_inter; 1.
DR   SMART; SM01058; CarD_TRCF; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SMART; SM00982; TRCF; 1.
DR   SUPFAM; SSF141259; SSF141259; 1.
DR   SUPFAM; SSF143517; SSF143517; 1.
DR   SUPFAM; SSF52540; SSF52540; 3.
DR   TIGRFAMs; TIGR00580; mfd; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA damage; DNA repair; DNA-binding; Helicase;
KW   Hydrolase; Nucleotide-binding.
FT   CHAIN           1..1122
FT                   /note="Transcription-repair-coupling factor"
FT                   /id="PRO_0000281072"
FT   DOMAIN          593..758
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00969"
FT   DOMAIN          779..933
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00969"
FT   MOTIF           711..714
FT                   /note="DEEQ box"
FT   BINDING         606..613
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00969"
SQ   SEQUENCE   1122 AA;  127560 MW;  AA303708D4815E79 CRC64;
     MLQQKFPAAA KSFFAIDNFT KNLKQDFILS ASNEEEALQL YKQALFFSSN ENIYYFPSYN
     TIPYDHTSPN ANILSRRAET LIKLTTNNSN SNKLLITHTA NLLNKLPPKD FFSKYFLKLS
     PKMKFTTDEL AMFLVENSFT RNASSIDVGE FAVRGEIIDI ILSGPKAYRI HFSWGYIESI
     KEFDIDTQIS TKSCRELIIS PANEIVLNSE TIGNFKNNYL RNFGVNHTDN ALYEAVISGR
     KFTGYEQLLP LFYDSCSNLI DYLNDPIFIF DNLSKKAILE FEHSYNDFYS ARSEANKLKF
     NSFYPTLSPT SLYFTASEIT ELLEQKNNIL LTFENSEQAS LIKNIAATSF IEKKTVFDKL
     FEVIKANSHK KIIIGSSVLS SFERIKSIIQ NYEYKYNEIN KLDEAKASII NVAIIPLNQS
     FYTKEYLFIT ASELLEEKPS STNTNKKLKN ILLELDNLAE GEFVVHKDHG IGQFLKLEAL
     EIKGKPHDFL KILYAGNDKL YIPVESIEVI KKYGNDNAEL DKLGSVSWQR SKAKLKKRIK
     EIALHLIQIA AKRKLNSSAS VEFDLEEYDK FCANFPFSET EDQLIAINDI KEDLRNGMLM
     DRLICGDVGF GKTEVAMRAV FMVAKSLNEH LPQVAVVVPT TILCSQHFSR FIERFKGFGL
     NIKQLSSVIS SKEAKIIRSE LESGKINIII GTHSLLHKNI KFFNLKLLII DEEQHFGVGQ
     KEFLKSLKSS SHVLAMSATP IPRTLQMSMT GLKELSIIAT PPLNRLEVHT SVMPYDPVII
     RDALLREHFR GGRSFYVVPR IKDIEDIAKQ LKQIVPELSY KIAYGKMTPS KIDEVMSEFY
     AGKFDILVST TIIESGIDIA EANTMIIHNA DMLGLSQLYQ LRGRIGRGKM RGYAYLTVAS
     HKKMTSHSLR RLEIIQNSCA LGSGFTIASR DMDLRGFGNL IGEEQSGQIK EVGTELYQEM
     LEEQIAIFKD ESIVSEQPFI PTINLGLSVF IPDNYVADAA LKLGLYRRIG NLSNEIEVET
     FKDEMIDRFG LLPIEFNNLL DIVKIKLLCF KLNIENLDSG DNGFVIKFYK NADMTDKILK
     FVTTYSNQAK IKPDNKLVYI KKLVDKNIIV EANQLLWNLS EV
 
 
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