ID   MFFA_DANRE              Reviewed;         275 AA.
AC   Q503U3;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Mitochondrial fission factor homolog A;
GN   ORFNames=zgc:110130;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in mitochondrial and peroxisomal fission.
CC       Promotes the recruitment and association of the fission mediator
CC       dynamin-related protein 1 (DNM1L) to the mitochondrial surface (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC       Single-pass type IV membrane protein {ECO:0000250}. Peroxisome
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Tango11 family. {ECO:0000305}.
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DR   EMBL; BC095179; AAH95179.1; -; mRNA.
DR   RefSeq; NP_001018402.2; NM_001020566.2.
DR   AlphaFoldDB; Q503U3; -.
DR   STRING; 7955.ENSDARP00000120140; -.
DR   PaxDb; Q503U3; -.
DR   PeptideAtlas; Q503U3; -.
DR   GeneID; 553588; -.
DR   KEGG; dre:553588; -.
DR   CTD; 553588; -.
DR   ZFIN; ZDB-GENE-050522-208; mffb.
DR   eggNOG; ENOG502R96B; Eukaryota.
DR   InParanoid; Q503U3; -.
DR   OrthoDB; 1383657at2759; -.
DR   PhylomeDB; Q503U3; -.
DR   PRO; PR:Q503U3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0031307; C:integral component of mitochondrial outer membrane; IBA:GO_Central.
DR   GO; GO:0005777; C:peroxisome; ISS:UniProtKB.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0000266; P:mitochondrial fission; ISS:UniProtKB.
DR   GO; GO:0090141; P:positive regulation of mitochondrial fission; ISS:UniProtKB.
DR   GO; GO:0090314; P:positive regulation of protein targeting to membrane; ISS:UniProtKB.
DR   GO; GO:0006626; P:protein targeting to mitochondrion; IBA:GO_Central.
DR   InterPro; IPR039433; Mff-like_dom.
DR   InterPro; IPR008518; Mff/Tango-11.
DR   PANTHER; PTHR16501; PTHR16501; 2.
DR   Pfam; PF05644; Miff; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW   Peroxisome; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..275
FT                   /note="Mitochondrial fission factor homolog A"
FT                   /id="PRO_0000289188"
FT   TOPO_DOM        1..255
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        256..273
FT                   /note="Helical; Anchor for type IV membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        274..275
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   REGION          100..171
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          223..253
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        116..133
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        134..148
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   275 AA;  31360 MW;  DF48B959C6D7A677 CRC64;
     MAEVNRIHYE LEYTEGISQQ MRIPERLKIA SGSSEEPPGL LNASHSTMML VPERIVIAGD
     DNDARFGRPR DLDLIQSTPL ETVELKTPPR VLTLNDQPLD FLEPEPAANS TAQPREEMKS
     HFRSRREQCR SENSTMRRNG QINKHDFASP SPSRAPVRVC PPLISPEDSQ NLNSASGVLN
     YIKSTTRRAY QQVLEVLDDS QRGRASLVTF DASVENTPDD AGLTDAASLR RQIIKLNRRL
     QLLEHENKER AKREMVMYSL TVAFWLVNSW IWLRR