ID   MFFB_XENLA              Reviewed;         239 AA.
AC   Q6GQI8;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Mitochondrial fission factor homolog B;
GN   Name=mff-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in mitochondrial and peroxisomal fission.
CC       Promotes the recruitment and association of the fission mediator
CC       dynamin-related protein 1 (DNM1L) to the mitochondrial surface (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC       Single-pass type IV membrane protein {ECO:0000250}. Peroxisome
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Tango11 family. {ECO:0000305}.
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DR   EMBL; BC072754; AAH72754.1; -; mRNA.
DR   RefSeq; NP_001085443.1; NM_001091974.1.
DR   AlphaFoldDB; Q6GQI8; -.
DR   SMR; Q6GQI8; -.
DR   DNASU; 443869; -.
DR   GeneID; 443869; -.
DR   KEGG; xla:443869; -.
DR   CTD; 443869; -.
DR   Xenbase; XB-GENE-5870309; mff.L.
DR   OrthoDB; 1383657at2759; -.
DR   Proteomes; UP000186698; Chromosome 5L.
DR   Bgee; 443869; Expressed in ovary and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005777; C:peroxisome; ISS:UniProtKB.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0000266; P:mitochondrial fission; ISS:UniProtKB.
DR   GO; GO:0090141; P:positive regulation of mitochondrial fission; ISS:UniProtKB.
DR   GO; GO:0090314; P:positive regulation of protein targeting to membrane; ISS:UniProtKB.
DR   InterPro; IPR039433; Mff-like_dom.
DR   InterPro; IPR008518; Mff/Tango-11.
DR   PANTHER; PTHR16501; PTHR16501; 2.
DR   Pfam; PF05644; Miff; 2.
PE   2: Evidence at transcript level;
KW   Coiled coil; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW   Peroxisome; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..239
FT                   /note="Mitochondrial fission factor homolog B"
FT                   /id="PRO_0000289191"
FT   TOPO_DOM        1..219
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        220..237
FT                   /note="Helical; Anchor for type IV membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        238..239
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   REGION          107..139
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          184..214
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   239 AA;  26799 MW;  E0CF1555871AABAB CRC64;
     MAEINRMQYE REYTEGISQS MRVPEKLKVA PSNSGVDPKT QPDMPIPGVF MEVPERIVIA
     GHSEESLFSR PSNLDFIPGA NIAALALKTP PRVLTLSERP LDFLDLEGPA PATPHSKEVR
     SSGHLKRDGL ASENSLRQNG QLVRHDSMPI LRCGSSTSVP VTHHDNPRSA MSTLDTTLDS
     TPDDLALADA ASLRRQIIKL NRRLLLLEEE NKERVKHEMT MYSIIIIFGL LNSWLWFRR