ID   MFF_XENLA               Reviewed;         219 AA.
AC   Q6DD53;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Mitochondrial fission factor homolog A;
GN   Name=mff-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in mitochondrial and peroxisomal fission.
CC       Promotes the recruitment and association of the fission mediator
CC       dynamin-related protein 1 (DNM1L) to the mitochondrial surface (By
CC       similarity). {ECO:0000250|UniProtKB:Q6PCP5,
CC       ECO:0000250|UniProtKB:Q9GZY8}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC       {ECO:0000250|UniProtKB:Q6PCP5}; Single-pass type IV membrane protein
CC       {ECO:0000255}. Peroxisome {ECO:0000250|UniProtKB:Q9GZY8}. Cytoplasmic
CC       vesicle, secretory vesicle, synaptic vesicle
CC       {ECO:0000250|UniProtKB:Q4KM98}.
CC   -!- SIMILARITY: Belongs to the Tango11 family. {ECO:0000305}.
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DR   EMBL; BC077775; AAH77775.1; -; mRNA.
DR   RefSeq; NP_001086925.1; NM_001093456.1.
DR   AlphaFoldDB; Q6DD53; -.
DR   SMR; Q6DD53; -.
DR   DNASU; 446760; -.
DR   GeneID; 446760; -.
DR   CTD; 446760; -.
DR   Xenbase; XB-GENE-6255354; mff.S.
DR   OrthoDB; 1383657at2759; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   Bgee; 446760; Expressed in testis and 19 other tissues.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005741; C:mitochondrial outer membrane; ISS:UniProtKB.
DR   GO; GO:0005777; C:peroxisome; ISS:UniProtKB.
DR   GO; GO:0008021; C:synaptic vesicle; IEA:UniProtKB-SubCell.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0000266; P:mitochondrial fission; ISS:UniProtKB.
DR   GO; GO:0090141; P:positive regulation of mitochondrial fission; ISS:UniProtKB.
DR   GO; GO:0090314; P:positive regulation of protein targeting to membrane; ISS:UniProtKB.
DR   GO; GO:0006626; P:protein targeting to mitochondrion; ISS:UniProtKB.
DR   InterPro; IPR039433; Mff-like_dom.
DR   InterPro; IPR008518; Mff/Tango-11.
DR   PANTHER; PTHR16501; PTHR16501; 2.
DR   Pfam; PF05644; Miff; 2.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasmic vesicle; Membrane; Mitochondrion;
KW   Mitochondrion outer membrane; Peroxisome; Reference proteome; Synapse;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..219
FT                   /note="Mitochondrial fission factor homolog A"
FT                   /id="PRO_0000289190"
FT   TOPO_DOM        1..199
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        200..217
FT                   /note="Helical; Anchor for type IV membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        218..219
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   COILED          164..194
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   219 AA;  24673 MW;  0EE43345E9E176C3 CRC64;
     MAEINRMQYE IDYTEGISQR MRVPEMLKVA PGNLGANLKA QQDMPIPGVV MEVPERIVVA
     GQSEESPFSR PSDLDFISGT NIGTLALKTP PRVLTLSERP LDFLDLEGLT PATPQSEEIR
     SSGHLKRDKF SSENALRQNG QLVRHDSMSA MSTLDTTLDA TADDLALADA ASLRRQIIKL
     NRRLLLLEEE NKERVKHEMT MYSIIIIFGL LNSWLWLRR