MFG1_CANAL
ID MFG1_CANAL Reviewed; 758 AA.
AC Q59Y46; A0A1D8PIC4;
DT 03-SEP-2014, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2017, sequence version 2.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Morphogenetic regulator of filamentous growth protein 1;
GN Name=MFG1; OrderedLocusNames=CAALFM_C208730WA;
GN ORFNames=CaO19.11086, CaO19.3603;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=22984072; DOI=10.1126/science.1224339;
RA Ryan O., Shapiro R.S., Kurat C.F., Mayhew D., Baryshnikova A., Chin B.,
RA Lin Z.Y., Cox M.J., Vizeacoumar F., Cheung D., Bahr S., Tsui K., Tebbji F.,
RA Sellam A., Istel F., Schwarzmuller T., Reynolds T.B., Kuchler K.,
RA Gifford D.K., Whiteway M., Giaever G., Nislow C., Costanzo M.,
RA Gingras A.C., Mitra R.D., Andrews B., Fink G.R., Cowen L.E., Boone C.;
RT "Global gene deletion analysis exploring yeast filamentous growth.";
RL Science 337:1353-1356(2012).
CC -!- FUNCTION: Transcriptional regulator with a general role in all
CC morphogenetically distinct forms of filamentous growth, namely invasive
CC growth and biofilm formation. May control FLO11 gene expression as part
CC of a promoter-bound complex with FLO8 and MSS1. Important for
CC virulence. {ECO:0000269|PubMed:22984072}.
CC -!- SUBUNIT: Interacts with FLO8 and MSS11, both morphogenetic
CC transcription factors binding directly to the FLO11 promoter.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- DISRUPTION PHENOTYPE: Defective in filamentation and invasive growth in
CC response to environmental cues. Defective in the formation of biofilms.
CC Displays decreased virulence in the greater wax moth Galleria
CC mellonella infection model. {ECO:0000269|PubMed:22984072}.
CC -!- SIMILARITY: Belongs to the MFG1 family. {ECO:0000305}.
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DR EMBL; CP017624; AOW27861.1; -; Genomic_DNA.
DR RefSeq; XP_714447.2; XM_709354.2.
DR AlphaFoldDB; Q59Y46; -.
DR BioGRID; 1226935; 2.
DR STRING; 237561.Q59Y46; -.
DR PRIDE; Q59Y46; -.
DR GeneID; 3643884; -.
DR KEGG; cal:CAALFM_C208730WA; -.
DR CGD; CAL0000181361; MFG1.
DR VEuPathDB; FungiDB:C2_08730W_A; -.
DR eggNOG; ENOG502QUF6; Eukaryota.
DR HOGENOM; CLU_367595_0_0_1; -.
DR InParanoid; Q59Y46; -.
DR OrthoDB; 1456452at2759; -.
DR PRO; PR:Q59Y46; -.
DR Proteomes; UP000000559; Chromosome 2.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR InterPro; IPR029005; LIM-bd/SEUSS.
DR PANTHER; PTHR10378; PTHR10378; 1.
DR Pfam; PF01803; LIM_bind; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..758
FT /note="Morphogenetic regulator of filamentous growth
FT protein 1"
FT /id="PRO_0000430246"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 87..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 408..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 650..758
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..228
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..293
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 650..735
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 736..758
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 758 AA; 83409 MW; 8AA75D24391BE6A5 CRC64;
MNGNNNTGNL QQSHGPPQQQ QQQQMFNQTP QMGFQQAPPP GMQGRGNNAQ TPLQQQRFNM
SQQQMMAAQQ QQQQQQLQQQ NAMAAAAAAA AASGRPVPQR NPNYNGSPNP GQTLPLNNNN
NNSNNNNNKT GMYNPNALAT GMPSSNLQPT SSAGNSRGHT PRMVNQPQPF IPHQQNQPPL
PPQQQQQQQQ QQQQPTPQLP PQGQTPQQVQ MGYPKKVNNG NLVANQSLKS GPMGGPVPMG
GPQQARIPPN SSFQQSPQTQ FAMPPNSNGP INPQQQQQQH GPNQNPQPTV SGRSPIQRQM
IIATTTATGG KGDTNNSVQE QVQQEINTRI IKRNLGNAAI IRVLDLIEFI SNQHYENLSN
IEFWTKITPA NFLPTAILKF NTTNITGGNG NKSLNDITGL NLNFLNSNKA TSNNNNNNTN
TNTNNSNNNN KPHQFELTTS TAPRFFASCI QTESILKCNI SLSGSKFQVL SNGSIVIVSK
IGLHFHYKDG SNSALHGTIK ILMSKDLRIE WVDLNFSDYQ SNISVSALEE KLKSIITDNT
SITKKDIKRQ KELLDELVKN SQASKLQLTF GIEPQSLRIL QLGDVMSSMK SLMEFSMVNN
IPSPMKSMEL LIASQKNQQM QAFQAQMAVQ AQAQAQAQVQ AQAQGQNLAN FSGSTNLQTD
AQRSRQQQQQ QQQQQQQQQQ QQSLNTSNNN SNSNNSNNNN NNNSNNNNNN NNNNNGKGGI
ANGSNNISSP SPRTVNAEEP KRKRKQSVNM SNENKRRK
