MFG1_YEAST
ID MFG1_YEAST Reviewed; 458 AA.
AC Q07684; D6VRC3;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Morphogenetic regulator of filamentous growth protein 1;
GN Name=MFG1; OrderedLocusNames=YDL233W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169867;
RA Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA Mewes H.-W., Zollner A., Zaccaria P.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL Nature 387:75-78(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [4]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
RA Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
RT "A multidimensional chromatography technology for in-depth phosphoproteome
RT analysis.";
RL Mol. Cell. Proteomics 7:1389-1396(2008).
RN [6]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RC STRAIN=Sigma 1278B;
RX PubMed=22984072; DOI=10.1126/science.1224339;
RA Ryan O., Shapiro R.S., Kurat C.F., Mayhew D., Baryshnikova A., Chin B.,
RA Lin Z.Y., Cox M.J., Vizeacoumar F., Cheung D., Bahr S., Tsui K., Tebbji F.,
RA Sellam A., Istel F., Schwarzmuller T., Reynolds T.B., Kuchler K.,
RA Gifford D.K., Whiteway M., Giaever G., Nislow C., Costanzo M.,
RA Gingras A.C., Mitra R.D., Andrews B., Fink G.R., Cowen L.E., Boone C.;
RT "Global gene deletion analysis exploring yeast filamentous growth.";
RL Science 337:1353-1356(2012).
CC -!- FUNCTION: Transcriptional regulator with a general role in all
CC morphogenetically distinct forms of filamentous growth, namely haploid
CC invasive growth, biofilm formation, and diploid pseudohyphal growth.
CC May control FLO11 gene expression as part of a promoter-bound complex
CC with FLO8 and MSS1. {ECO:0000269|PubMed:22984072}.
CC -!- SUBUNIT: Interacts with FLO8 and MSS11, both morphogenetic
CC transcription factors binding directly to the FLO11 promoter.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14562095,
CC ECO:0000269|PubMed:22984072}.
CC -!- MISCELLANEOUS: Present with 1010 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the MFG1 family. {ECO:0000305}.
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DR EMBL; Z74281; CAA98812.1; -; Genomic_DNA.
DR EMBL; BK006938; DAA11633.1; -; Genomic_DNA.
DR PIR; S67796; S67796.
DR RefSeq; NP_010048.1; NM_001180293.1.
DR AlphaFoldDB; Q07684; -.
DR BioGRID; 31878; 90.
DR DIP; DIP-4624N; -.
DR STRING; 4932.YDL233W; -.
DR iPTMnet; Q07684; -.
DR PaxDb; Q07684; -.
DR PRIDE; Q07684; -.
DR EnsemblFungi; YDL233W_mRNA; YDL233W; YDL233W.
DR GeneID; 851365; -.
DR KEGG; sce:YDL233W; -.
DR SGD; S000002392; MFG1.
DR VEuPathDB; FungiDB:YDL233W; -.
DR eggNOG; ENOG502QUF6; Eukaryota.
DR HOGENOM; CLU_597380_0_0_1; -.
DR InParanoid; Q07684; -.
DR OMA; YLSNMAI; -.
DR BioCyc; YEAST:G3O-29611-MON; -.
DR PRO; PR:Q07684; -.
DR Proteomes; UP000002311; Chromosome IV.
DR RNAct; Q07684; protein.
DR GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR GO; GO:0005634; C:nucleus; HDA:SGD.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR029005; LIM-bd/SEUSS.
DR PANTHER; PTHR10378; PTHR10378; 1.
DR Pfam; PF01803; LIM_bind; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..458
FT /note="Morphogenetic regulator of filamentous growth
FT protein 1"
FT /id="PRO_0000242483"
FT REGION 401..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..442
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 443..458
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 458 AA; 51320 MW; F29336D075719C2C CRC64;
MYQGPPQPPP QAVPMPYIVN NNTPPYPNGN INFPPTAQQN IPPTVYPQQV PFPGQPQGGQ
FPQPSSEQQV FNQLPQVTQT FHNSAQNTNA TGGPGSGSMP MFTPVASFPH PMATAATAAA
PLPRSASQAS LSMLRVPYHV RKYLSNLAML KLYEIINEVN TAMGKIGLLS FWTELISDIF
TPDAVIRYSK KSMTDYREFE FIIPVFPVIC STLGRFGIVR MEVKVLQLKT QVLSNSTIFF
NCPRVTFVYY YPDGSYITHF SQMKGAFDLD LKINWLDVSM HSFVPDIEWN AVERLLSDDT
KSTEIEQIFR KLKQEDVKEQ GNSFAENNAT NVPPNFEAIT QLRSYFDVFR NVSVFGTQEG
LMRVMQISTV MSTLKNLRKF QIEKNIDSPV TALSAYIDAD KKDSGSEPLH AKRRRNSGIS
PRTTTLGPNG NSNTSNEELP TSDVNDINKD MTKKKMKF
