ID   MFGM_CAPHI              Reviewed;          12 AA.
AC   P85297;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   02-JUN-2021, entry version 18.
DE   RecName: Full=Lactadherin;
DE   AltName: Full=MFGM;
DE   AltName: Full=Milk fat globule-EGF factor 8;
DE            Short=MFG-E8;
DE   AltName: Full=SED1;
DE   Flags: Fragment;
GN   Name=MFGE8 {ECO:0000250|UniProtKB:P79385};
OS   Capra hircus (Goat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Capra.
OX   NCBI_TaxID=9925;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE.
RA   Koenig S., Mehlich A.M., Ackermann D.;
RT   "Access to lower abundant bovine and caprine whey proteins: the impact of
RT   caseins and lactoglobulin on proteome analysis.";
RL   Anal. Bioanal. Chem. 0:0-0(2007).
CC   -!- FUNCTION: Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5
CC       receptors. Also binds to phosphatidylserine-enriched cell surfaces in a
CC       receptor-independent manner. Zona pellucida-binding protein which may
CC       play a role in gamete interaction. Contributes to phagocytic removal of
CC       apoptotic cells in many tissues. Plays an important role in the
CC       maintenance of intestinal epithelial homeostasis and the promotion of
CC       mucosal healing. Promotes VEGF-dependent neovascularization (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P79385};
CC       Peripheral membrane protein {ECO:0000250|UniProtKB:P79385}. Secreted
CC       {ECO:0000250|UniProtKB:P79385}. Cytoplasmic vesicle, secretory vesicle,
CC       acrosome membrane {ECO:0000250|UniProtKB:P79385}; Peripheral membrane
CC       protein {ECO:0000250|UniProtKB:P79385}. Note=Located in the acrosomal
CC       region of zona-pellucida bound sperm. {ECO:0000250|UniProtKB:P79385}.
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DR   Proteomes; UP000291000; Unassembled WGS sequence.
DR   GO; GO:0002080; C:acrosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0007338; P:single fertilization; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Angiogenesis; Cell adhesion; Cytoplasmic vesicle;
KW   Direct protein sequencing; Fertilization; Membrane; Reference proteome;
KW   Secreted.
FT   CHAIN           <1..>12
FT                   /note="Lactadherin"
FT                   /id="PRO_0000308187"
FT   UNSURE          5
FT                   /note="I or L"
FT   UNSURE          6
FT                   /note="Q or K"
FT   NON_TER         1
FT   NON_TER         12
SQ   SEQUENCE   12 AA;  1440 MW;  0224905796DB46D0 CRC64;
     DFGHIQYVAA YR