ID   MFGM_EQUAS              Reviewed;          24 AA.
AC   C0HJR4;
DT   29-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2015, sequence version 1.
DT   25-MAY-2022, entry version 9.
DE   RecName: Full=Lactadherin {ECO:0000303|Ref.1};
DE   AltName: Full=MFGM {ECO:0000250|UniProtKB:Q08431};
DE   AltName: Full=Milk fat globule-EGF factor 8 {ECO:0000250|UniProtKB:Q08431};
DE            Short=MFG-E8 {ECO:0000250|UniProtKB:Q08431};
DE   Flags: Fragment;
GN   Name=MFGE8 {ECO:0000250|UniProtKB:Q08431};
OS   Equus asinus (Donkey) (Equus africanus asinus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9793 {ECO:0000303|Ref.1};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE.
RA   Civra A., Giuffrida M., Donalisio M., Napolitano L., Takada Y., Coulson B.,
RA   Conti A., Lembo D.;
RT   "Identification of equine lactadherin-derived peptides that inhibit
RT   rotavirus infection via integrin receptor competition.";
RL   Submitted (FEB-2015) to UniProtKB.
CC   -!- FUNCTION: Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5
CC       receptors. Also binds to phosphatidylserine-enriched cell surfaces in a
CC       receptor-independent manner. Zona pellucida-binding protein which may
CC       play a role in gamete interaction. Contributes to phagocytic removal of
CC       apoptotic cells in many tissues. Plays an important role in the
CC       maintenance of intestinal epithelial homeostasis and the promotion of
CC       mucosal healing. Promotes VEGF-dependent neovascularization.
CC       {ECO:0000250|UniProtKB:Q08431}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P79385};
CC       Peripheral membrane protein {ECO:0000250|UniProtKB:P79385}. Secreted
CC       {ECO:0000250|UniProtKB:P79385}. Cytoplasmic vesicle, secretory vesicle,
CC       acrosome membrane {ECO:0000250|UniProtKB:P79385}; Peripheral membrane
CC       protein {ECO:0000250|UniProtKB:P79385}. Note=Located in the acrosomal
CC       region of zona-pellucida bound sperm. {ECO:0000250|UniProtKB:P79385}.
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DR   AlphaFoldDB; C0HJR4; -.
DR   GO; GO:0002080; C:acrosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0007338; P:single fertilization; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Angiogenesis; Cell adhesion; Cytoplasmic vesicle;
KW   Direct protein sequencing; Fertilization; Membrane; Secreted.
FT   CHAIN           1..>24
FT                   /note="Lactadherin"
FT                   /evidence="ECO:0000269|Ref.1"
FT                   /id="PRO_0000432998"
FT   NON_TER         24
FT                   /evidence="ECO:0000269|Ref.1"
SQ   SEQUENCE   24 AA;  2599 MW;  5E3D0A06589AF02A CRC64;
     ASGPCFPNPC QNDGECHVID DSHR