ID   MFHA1_XENTR             Reviewed;         997 AA.
AC   A4IIK1;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Malignant fibrous histiocytoma-amplified sequence 1 homolog {ECO:0000305};
GN   Name=mfhas1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable GTP-binding protein. Functions in innate immunity
CC       and more specifically the inflammatory response as a regulator of the
CC       Toll-like receptor TLR2 and TLR4 signaling pathways.
CC       {ECO:0000250|UniProtKB:Q9Y4C4}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9Y4C4}.
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DR   EMBL; BC136050; AAI36051.1; -; mRNA.
DR   RefSeq; NP_001096407.1; NM_001102937.1.
DR   AlphaFoldDB; A4IIK1; -.
DR   SMR; A4IIK1; -.
DR   STRING; 8364.ENSXETP00000000786; -.
DR   PaxDb; A4IIK1; -.
DR   GeneID; 100125009; -.
DR   KEGG; xtr:100125009; -.
DR   CTD; 9258; -.
DR   Xenbase; XB-GENE-1003080; mfhas1.
DR   eggNOG; KOG0619; Eukaryota.
DR   InParanoid; A4IIK1; -.
DR   OrthoDB; 1013039at2759; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0009966; P:regulation of signal transduction; IEA:UniProt.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR032171; COR.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR020859; ROC_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF16095; COR; 1.
DR   Pfam; PF13855; LRR_8; 2.
DR   SMART; SM00369; LRR_TYP; 9.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51450; LRR; 13.
DR   PROSITE; PS51424; ROC; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; GTP-binding; Immunity; Inflammatory response; Innate immunity;
KW   Leucine-rich repeat; Nucleotide-binding; Reference proteome; Repeat.
FT   CHAIN           1..997
FT                   /note="Malignant fibrous histiocytoma-amplified sequence 1
FT                   homolog"
FT                   /id="PRO_0000308611"
FT   REPEAT          32..53
FT                   /note="LRR 1"
FT   REPEAT          54..76
FT                   /note="LRR 2"
FT   REPEAT          79..100
FT                   /note="LRR 3"
FT   REPEAT          102..123
FT                   /note="LRR 4"
FT   REPEAT          125..146
FT                   /note="LRR 5"
FT   REPEAT          148..170
FT                   /note="LRR 6"
FT   REPEAT          171..192
FT                   /note="LRR 7"
FT   REPEAT          194..216
FT                   /note="LRR 8"
FT   REPEAT          218..239
FT                   /note="LRR 9"
FT   REPEAT          241..262
FT                   /note="LRR 10"
FT   REPEAT          264..286
FT                   /note="LRR 11"
FT   REPEAT          287..308
FT                   /note="LRR 12"
FT   REPEAT          310..331
FT                   /note="LRR 13"
FT   REPEAT          333..354
FT                   /note="LRR 14"
FT   DOMAIN          393..626
FT                   /note="Roc"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00758"
SQ   SEQUENCE   997 AA;  113096 MW;  397EA4319B9822B6 CRC64;
     MAGNDTCNNS CDVKTARLWR DAALRSRKLR SSLRQLTLSC VDKRKLILPA DLGDVEVLNL
     GNNSLEEVPD GLQSLSAGNL HVLILRRNKF LNVPTAVYHL GRLTELDISY NRLSCLTEAV
     GLLGKLKKLC LSHNQLRTLP RQLGMLVDLE ELDVSFNQIT HLPDTMQGLP SLRTLDLDHN
     ELCSFPQQLF HVPALEELDF SGNKMLGSLP EGIRSMQSLK ILWLSSTSLC LLPDSICELV
     NLESLMLDNN NLHTLPEGFG ALQKLKMLNV SSNAFQDFPV PLLQLVDLEE LYMSRNRLVV
     LPEVISCMTK LVTLWLDNNR IRYLPDSIVE LSFLEELVLQ GNQIAILPDD FGKLSKVNIW
     KIKDNPLIQP PYEVCMKGIS YIAAYQKELA HSQPAVKPRL KLVLLGLKDA GKTLLRQCLT
     DEQNTSTLVQ GYKGIEITNW TADAERGLAF IVYDLAGDQS YDIIKPFFFS PGALYILVVN
     LKSYVCKHFY THVGYFIHLI TSKVPHAVVC IVGTHIDLCN EKELEEKCLD IHHQIAVQEK
     RDSETLQTLI QTVDKALSQD FDFRASNPHS AFYGVSDKNL RRKKTHFQYL MNSRLQILSP
     VLCVSCLDFS NIKRLREKLL SVAEHREIFP NLHRVLPKSW QMLEELHFKP QELWLTWWDS
     ARLGLQAGLT EDRMQSALSF LHESGKLLYF EDNQTLKEYV FHNLTKLIDI LNVFFQRDAS
     VLFAKLTSDA TADETKVTQF HHYVEGFLLH GLLPTHIIRS LLKPHIKTHQ DLQLILELLE
     KMGLCYCINK PKNKLLNGAT VWYKFPCYVK NEAPHAEAWI NGTNISEPCL AVEQLQIEYS
     FPFIFPPGLF ARFSVQINSH IVHRSDSKFQ IFAYRGKVPV VVSFQPARGA LQPGILSIAS
     HASLPNIWTA WQAITPLVEE LNALLQEWPS LYYTVHVLCS KCLKRGSPNP HPFPGELLSQ
     PRPDGVTELI CPKNGSERLN VSLVYPPTPT MISPCSK