ID   MFI_RAT                 Reviewed;         305 AA.
AC   Q569B9;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Protein MFI {ECO:0000305};
DE   AltName: Full=Mitochondrial fission factor interactor {ECO:0000250|UniProtKB:Q9D4W2};
DE   AltName: Full=Protein C11orf65 homolog;
GN   Name=Mfi {ECO:0000250|UniProtKB:Q9D4W2};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Acts as an inhibitor of mitochondrial fission. Interacts with
CC       MFF and prevents DNM1L recruitment to mitochondria, promoting a more
CC       fused mitochondrial network. {ECO:0000250|UniProtKB:Q9D4W2}.
CC   -!- SUBUNIT: Can homodimerize. Interacts with MFF; the interaction inhibits
CC       MFF interaction with DNM1L. {ECO:0000250|UniProtKB:Q9D4W2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:Q9D4W2}. Mitochondrion outer membrane
CC       {ECO:0000250|UniProtKB:Q9D4W2}. Note=Predominantly localizes to the
CC       cytosol, with a minor fraction at the outer mitochondrial membrane.
CC       {ECO:0000250|UniProtKB:Q9D4W2}.
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DR   EMBL; BC092578; AAH92578.1; -; mRNA.
DR   RefSeq; NP_001019436.1; NM_001024265.1.
DR   RefSeq; XP_006243140.1; XM_006243078.3.
DR   RefSeq; XP_006243141.1; XM_006243079.3.
DR   RefSeq; XP_006243142.1; XM_006243080.3.
DR   RefSeq; XP_008764485.1; XM_008766263.2.
DR   AlphaFoldDB; Q569B9; -.
DR   STRING; 10116.ENSRNOP00000009562; -.
DR   PhosphoSitePlus; Q569B9; -.
DR   PaxDb; Q569B9; -.
DR   PRIDE; Q569B9; -.
DR   GeneID; 315665; -.
DR   KEGG; rno:315665; -.
DR   UCSC; RGD:1311251; rat.
DR   CTD; 315665; -.
DR   RGD; 1311251; RGD1311251.
DR   eggNOG; ENOG502QSTG; Eukaryota.
DR   HOGENOM; CLU_068479_0_0_1; -.
DR   InParanoid; Q569B9; -.
DR   PhylomeDB; Q569B9; -.
DR   TreeFam; TF328500; -.
DR   PRO; PR:Q569B9; -.
DR   Proteomes; UP000002494; Unplaced.
DR   Genevisible; Q569B9; RN.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005741; C:mitochondrial outer membrane; ISS:UniProtKB.
DR   GO; GO:0090258; P:negative regulation of mitochondrial fission; ISS:UniProtKB.
DR   GO; GO:1903215; P:negative regulation of protein targeting to mitochondrion; ISS:UniProtKB.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW   Reference proteome.
FT   CHAIN           1..305
FT                   /note="Protein MFI"
FT                   /id="PRO_0000263667"
SQ   SEQUENCE   305 AA;  36199 MW;  79DFF7AB68283F35 CRC64;
     MSMKRPQDHS KQEMAARIIQ KAWKTFLNVS VFQHFKSLID LRRQGEPRQI VKYINPKEAE
     LLDAAAGVQV RFRLGGVKFP PEIYYKIFTH RHIEDLCANS PRDYTKLPAR YASHNKDDPP
     QVEDNSGWYR RIENNGWRPV SNRFWMPTEN EVLESTKESE FHFSKLKRKQ DLEKKRKIKK
     IEWMRQMYYL GSLEAKVTDR ETLVLIHKAT KGLIKSIEDG GVDSVMEWEV DEVLNWTNTL
     NFDDYIASWR ETATSNSSAY LKDAKLQRIQ KSLQRKIYED ETKESEEKIY YDGDFYENVY
     IKPLL