ID   MFL2_PHOSM              Reviewed;         598 AA.
AC   A0A3G1DJE2;
DT   18-SEP-2019, integrated into UniProtKB/Swiss-Prot.
DT   13-FEB-2019, sequence version 1.
DT   25-MAY-2022, entry version 12.
DE   RecName: Full=MFS transporter L2 {ECO:0000303|PubMed:27056201};
DE   AltName: Full=Squalestatin S1 biosynthesis cluster protein L2 {ECO:0000303|PubMed:27056201};
GN   Name=L2 {ECO:0000303|PubMed:27056201};
OS   Phoma sp. (strain ATCC 20986 / MF5453).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Pleosporineae; Didymellaceae; Phoma.
OX   NCBI_TaxID=1828523;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=27056201; DOI=10.1039/c6cc02130a;
RA   Bonsch B., Belt V., Bartel C., Duensing N., Koziol M., Lazarus C.M.,
RA   Bailey A.M., Simpson T.J., Cox R.J.;
RT   "Identification of genes encoding squalestatin S1 biosynthesis and in vitro
RT   production of new squalestatin analogues.";
RL   Chem. Commun. (Camb.) 52:6777-6780(2016).
CC   -!- FUNCTION: MFS transporter; part of the gene cluster that mediates the
CC       biosynthesis of squalestatin S1 (SQS1, also known as zaragozic acid A),
CC       a lead compound for the treatment of hyper-cholesterolemia by targeting
CC       squalene synthase (SS). {ECO:0000269|PubMed:27056201}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; KU946987; AMY15055.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3G1DJE2; -.
DR   SMR; A0A3G1DJE2; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..598
FT                   /note="MFS transporter L2"
FT                   /id="PRO_0000447828"
FT   TRANSMEM        83..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        122..142
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        183..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        212..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        277..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        309..329
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        346..366
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        383..403
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        411..431
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        439..459
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        476..496
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        550..570
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        171
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        342
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   598 AA;  64911 MW;  5DD366CE6126841B CRC64;
     MEHNTDISTT QYNSHTVSTT TLSSFLVNVV TSSKRGNKMT TITAQPPRDE VEPAVPAPQL
     LSSDSASELS PKAEKFQPGW RFIAAFLSLC IIVLMAALDA TSISVALPSM ARALGGSAIE
     AFWAGTSFLL TSTIFQPVLG SFSHIFGRKS LIYISLVFFL AGSIIPAVAN NFTTILVGRS
     IQGVGGGGII ALTEMVVVDT VPLRERGKWF SFFGMMWSFG TVAGPLIGGA FAQKVSWRWV
     FWINLPFLGI GTVLITVFLK LNQRHGEFLA RLREVDWIGM VLFLGSTTGF LIPITWGGVQ
     YPWDSWRTLV PLIVSAAGIV AFIVHQEKFA PHPLIRTSVF KNKSAALLYL TTVIHGIILW
     AILYFMPLYF EAVKGMGPIM AGVALFPWTF TVAPGAVATG IAIAVTGKYR WANWAGWFLA
     TLGSGLLILL KPDTSTPAWI FLNLVGGIGT GILFPAMALA VQASASVKDQ AYAANMFSFF
     RAFGQTLGVA IGGVVFQNQM KAKLLTYPLL ADMADTYSKD AAGLVEIIKG MPAGLMKDQL
     KESYTDALKY IWIVATVLAG VSLVATLFID EFDMDIEMDT ERGFKEKSKV KDAEKETH