ID   MFN2A_XENLA             Reviewed;         186 AA.
AC   Q6GLJ0;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Mitoferrin-2A;
DE   AltName: Full=Mitochondrial iron transporter 2-A;
DE   AltName: Full=Solute carrier family 25 member 28-A;
GN   Name=slc25a28-a; Synonyms=mfrn2-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mitochondrial iron transporter that mediates iron uptake.
CC       Probably required for heme synthesis of hemoproteins and Fe-S cluster
CC       assembly in non-erythroid cells. The iron delivered into the
CC       mitochondria, presumably as Fe(2+), is then probably delivered to
CC       ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX
CC       to make heme (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; BC074495; AAH74495.1; -; mRNA.
DR   RefSeq; NP_001086329.1; NM_001092860.1.
DR   AlphaFoldDB; Q6GLJ0; -.
DR   SMR; Q6GLJ0; -.
DR   DNASU; 444758; -.
DR   GeneID; 444758; -.
DR   KEGG; xla:444758; -.
DR   CTD; 444758; -.
DR   Xenbase; XB-GENE-6254369; slc25a28.S.
DR   OrthoDB; 1056670at2759; -.
DR   Proteomes; UP000186698; Chromosome 7S.
DR   Bgee; 444758; Expressed in zone of skin and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 1.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 1.
PE   2: Evidence at transcript level;
KW   Ion transport; Iron; Iron transport; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..186
FT                   /note="Mitoferrin-2A"
FT                   /id="PRO_0000235258"
FT   TRANSMEM        77..96
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        137..157
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..185
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          75..163
FT                   /note="Solcar"
SQ   SEQUENCE   186 AA;  19762 MW;  96E7B9A5BDD545AD CRC64;
     MELEAVLKER TAAAGDPGRV LGAWVRSGWS AAGPSVLESE GGSGGPLAFE STSSRILELA
     SKDNEPEYEA LPDGSNVTTH MLAGAVAGVM EHCLMYPVDC VKTRMQSLQP DPAARYRNVM
     DALSKIVRTE GFWRPLRGLN VTATGAGPAH ALYFACYEKL KKTLSDIIHP GGNSHIANGT
     DYSCPA