ID   MFPP_AGRFC              Reviewed;         248 AA.
AC   A9CK30;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Mannosylfructose-phosphate phosphatase {ECO:0000312|EMBL:ABU63293.1};
DE            EC=3.1.3.79;
GN   Name=mfppA {ECO:0000312|EMBL:ABU63293.1}; OrderedLocusNames=Atu0660;
GN   ORFNames=AGR_C_1175;
OS   Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens
OS   (strain C58)).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Agrobacterium;
OC   Agrobacterium tumefaciens complex.
OX   NCBI_TaxID=176299;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:ABU63293.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], CATALYTIC ACTIVITY, ACTIVITY REGULATION,
RP   PATHWAY, AND INDUCTION.
RX   PubMed=17728402; DOI=10.1073/pnas.0706709104;
RA   Torres L.L., Salerno G.L.;
RT   "A metabolic pathway leading to mannosylfructose biosynthesis in
RT   Agrobacterium tumefaciens uncovers a family of mannosyltransferases.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:14318-14323(2007).
RN   [2] {ECO:0000312|EMBL:AAK86468.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C58 / ATCC 33970;
RX   PubMed=11743193; DOI=10.1126/science.1066804;
RA   Wood D.W., Setubal J.C., Kaul R., Monks D.E., Kitajima J.P., Okura V.K.,
RA   Zhou Y., Chen L., Wood G.E., Almeida N.F. Jr., Woo L., Chen Y.,
RA   Paulsen I.T., Eisen J.A., Karp P.D., Bovee D. Sr., Chapman P.,
RA   Clendenning J., Deatherage G., Gillet W., Grant C., Kutyavin T., Levy R.,
RA   Li M.-J., McClelland E., Palmieri A., Raymond C., Rouse G.,
RA   Saenphimmachak C., Wu Z., Romero P., Gordon D., Zhang S., Yoo H., Tao Y.,
RA   Biddle P., Jung M., Krespan W., Perry M., Gordon-Kamm B., Liao L., Kim S.,
RA   Hendrick C., Zhao Z.-Y., Dolan M., Chumley F., Tingey S.V., Tomb J.-F.,
RA   Gordon M.P., Olson M.V., Nester E.W.;
RT   "The genome of the natural genetic engineer Agrobacterium tumefaciens
RT   C58.";
RL   Science 294:2317-2323(2001).
RN   [3] {ECO:0000312|EMBL:AAK86468.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C58 / ATCC 33970;
RX   PubMed=11743194; DOI=10.1126/science.1066803;
RA   Goodner B., Hinkle G., Gattung S., Miller N., Blanchard M., Qurollo B.,
RA   Goldman B.S., Cao Y., Askenazi M., Halling C., Mullin L., Houmiel K.,
RA   Gordon J., Vaudin M., Iartchouk O., Epp A., Liu F., Wollam C., Allinger M.,
RA   Doughty D., Scott C., Lappas C., Markelz B., Flanagan C., Crowell C.,
RA   Gurson J., Lomo C., Sear C., Strub G., Cielo C., Slater S.;
RT   "Genome sequence of the plant pathogen and biotechnology agent
RT   Agrobacterium tumefaciens C58.";
RL   Science 294:2323-2328(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate
CC         + H2O = beta-D-fructofuranosyl alpha-D-mannopyranoside + phosphate;
CC         Xref=Rhea:RHEA:26019, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:51833, ChEBI:CHEBI:58870; EC=3.1.3.79;
CC         Evidence={ECO:0000269|PubMed:17728402};
CC   -!- ACTIVITY REGULATION: Inhibited by the phosphatase inhibitors fluoride,
CC       molybdate and orthovanadate. {ECO:0000269|PubMed:17728402}.
CC   -!- PATHWAY: Carbohydrate metabolism; mannosylfructose biosynthesis; beta-
CC       D-fructofuranosyl alpha-D-mannopyranoside from D-fructose 6-phosphate
CC       and GDP-alpha-D-mannose: step 2/2. {ECO:0000269|PubMed:17728402}.
CC   -!- INDUCTION: By salt. {ECO:0000269|PubMed:17728402}.
CC   -!- SIMILARITY: Belongs to the sucrose phosphatase family. {ECO:0000305}.
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DR   EMBL; AE007869; AAK86468.1; -; Genomic_DNA.
DR   EMBL; EF530046; ABU63293.1; -; Genomic_DNA.
DR   PIR; AF2657; AF2657.
DR   PIR; C97439; C97439.
DR   RefSeq; NP_353683.1; NC_003062.2.
DR   RefSeq; WP_010971047.1; NC_003062.2.
DR   AlphaFoldDB; A9CK30; -.
DR   SMR; A9CK30; -.
DR   STRING; 176299.Atu0660; -.
DR   EnsemblBacteria; AAK86468; AAK86468; Atu0660.
DR   GeneID; 66220825; -.
DR   KEGG; atu:Atu0660; -.
DR   PATRIC; fig|176299.10.peg.653; -.
DR   eggNOG; COG0561; Bacteria.
DR   HOGENOM; CLU_030534_0_1_5; -.
DR   OMA; DKGQAMQ; -.
DR   BioCyc; AGRO:ATU0660-MON; -.
DR   BioCyc; MetaCyc:MON-14461; -.
DR   BRENDA; 3.1.3.79; 200.
DR   UniPathway; UPA01006; UER01010.
DR   Proteomes; UP000000813; Chromosome circular.
DR   GO; GO:0016791; F:phosphatase activity; IDA:UniProtKB.
DR   GO; GO:0046351; P:disaccharide biosynthetic process; IDA:UniProtKB.
DR   Gene3D; 3.40.50.1000; -; 1.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR006379; HAD-SF_hydro_IIB.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR006380; SPP_N.
DR   Pfam; PF05116; S6PP; 1.
DR   SUPFAM; SSF56784; SSF56784; 1.
DR   TIGRFAMs; TIGR01484; HAD-SF-IIB; 1.
PE   1: Evidence at protein level;
KW   Hydrolase; Reference proteome.
FT   CHAIN           1..248
FT                   /note="Mannosylfructose-phosphate phosphatase"
FT                   /id="PRO_0000401101"
SQ   SEQUENCE   248 AA;  27282 MW;  A127873C64470459 CRC64;
     MKPLRLLSTD LDGTVVGDND ATRRFRDFWH ALPDDLRPVL VFNSGRLIDD QLALLEEVPL
     PQPDYIIGGV GTMLHAKKRS ELETAYTQSL GTGFDPRKIA DVMNRIAGVT MQEERYQHGL
     KSSWFLHDAD AAALGEIEAA LLAADIDARI VYSSDRDLDI LPKAADKGAA LAWLCGQLRI
     GLDESVVSGD TGNDRAMFEL KTIRGVIVGN ALPELVSLAH QDNRFFHSTA KEADGVIEGL
     RHWGLNPR