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MFR1_SCHPO
ID   MFR1_SCHPO              Reviewed;         421 AA.
AC   O94423;
DT   06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 149.
DE   RecName: Full=Meiotic fizzy-related protein 1;
GN   Name=mfr1; ORFNames=SPBC1198.12, SPBC660.02;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=11493649; DOI=10.1242/jcs.114.11.2135;
RA   Blanco M.A., Pelloquin L., Moreno S.;
RT   "Fission yeast mfr1 activates APC and coordinates meiotic nuclear division
RT   with sporulation.";
RL   J. Cell Sci. 114:2135-2143(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [3]
RP   INTERACTION WITH MES1.
RX   PubMed=15791259; DOI=10.1038/nature03406;
RA   Izawa D., Goto M., Yamashita A., Yamano H., Yamamoto M.;
RT   "Fission yeast Mes1p ensures the onset of meiosis II by blocking
RT   degradation of cyclin Cdc13p.";
RL   Nature 434:529-533(2005).
CC   -!- FUNCTION: Meiosis-specific activator of the anaphase promoting
CC       complex/cyclosome (APC/C). Involved in cdc13 degradation.
CC       {ECO:0000269|PubMed:11493649}.
CC   -!- SUBUNIT: Interacts with mes1. {ECO:0000269|PubMed:15791259}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11493649}.
CC   -!- SIMILARITY: Belongs to the WD repeat CDC20/Fizzy family. {ECO:0000305}.
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DR   EMBL; CU329671; CAB91187.1; -; Genomic_DNA.
DR   PIR; T40614; T40614.
DR   RefSeq; NP_595081.1; NM_001020987.1.
DR   AlphaFoldDB; O94423; -.
DR   SMR; O94423; -.
DR   BioGRID; 276581; 20.
DR   ComplexPortal; CPX-766; Anaphase-Promoting Complex variant 4.
DR   ELM; O94423; -.
DR   IntAct; O94423; 2.
DR   STRING; 4896.SPBC1198.12.1; -.
DR   iPTMnet; O94423; -.
DR   PaxDb; O94423; -.
DR   EnsemblFungi; SPBC1198.12.1; SPBC1198.12.1:pep; SPBC1198.12.
DR   GeneID; 2540043; -.
DR   KEGG; spo:SPBC1198.12; -.
DR   PomBase; SPBC1198.12; mfr1.
DR   VEuPathDB; FungiDB:SPBC1198.12; -.
DR   eggNOG; KOG0305; Eukaryota.
DR   HOGENOM; CLU_014831_4_2_1; -.
DR   InParanoid; O94423; -.
DR   OMA; MDQDYES; -.
DR   PhylomeDB; O94423; -.
DR   PRO; PR:O94423; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005680; C:anaphase-promoting complex; IBA:GO_Central.
DR   GO; GO:0010997; F:anaphase-promoting complex binding; IPI:PomBase.
DR   GO; GO:1990757; F:ubiquitin ligase activator activity; IDA:PomBase.
DR   GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IDA:PomBase.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:1905786; P:positive regulation of anaphase-promoting complex-dependent catabolic process; IBA:GO_Central.
DR   GO; GO:0075296; P:positive regulation of ascospore formation; IMP:PomBase.
DR   GO; GO:0051446; P:positive regulation of meiotic cell cycle; IMP:PomBase.
DR   GO; GO:1905191; P:positive regulation of metaphase/anaphase transition of meiosis II; IMP:PomBase.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR024977; Apc4_WD40_dom.
DR   InterPro; IPR033010; Cdc20/Fizzy.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19918; PTHR19918; 1.
DR   Pfam; PF12894; ANAPC4_WD40; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Meiosis; Nucleus; Reference proteome; Repeat; Sporulation; WD repeat.
FT   CHAIN           1..421
FT                   /note="Meiotic fizzy-related protein 1"
FT                   /id="PRO_0000051077"
FT   REPEAT          123..160
FT                   /note="WD 1"
FT   REPEAT          164..203
FT                   /note="WD 2"
FT   REPEAT          206..246
FT                   /note="WD 3"
FT   REPEAT          247..286
FT                   /note="WD 4"
FT   REPEAT          289..331
FT                   /note="WD 5"
FT   REPEAT          333..374
FT                   /note="WD 6"
FT   REPEAT          377..416
FT                   /note="WD 7"
FT   REGION          79..107
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        85..101
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   421 AA;  47237 MW;  9B9D86FF08DF97D5 CRC64;
     MGDRFIPIRN VSNEFNFSFQ SFKECVLSHG SNLRRKTSGT IQRQFMELLS MELFGSQASR
     SRAFYYGEDK RKIEKKMLDT PDRKSYSLSP ISPQSQDMLR QPQKPKRAFP KTPYKILDAP
     YLKNDFYLNL LDWGQSNVLA VGLASSIYLW SAASGKVVQL HDFGATNHVT SVLWTGKGTQ
     LAVGTDSGVI YIWDIESTKS VRSLKGHSER VAALAWNDNT LTSGGKDEVI LHHDLRAPGC
     CAEMMKVHEQ EICGLQWDRS LGQLASGGND NNLFVWDYRS SRPLHKFEEH TAAVKAIGWS
     PHQRGILASG GGTIDRCLTI HNTLTGRLQN KLDTGSQVCN MAWSKTSNEI VTTHGFAKNQ
     VSLWKYPSLK NIANLTAHTN RVLYLSMSPD GQSIVTGAGD ETLRFWKLFN KKPKEESTLI
     R
 
 
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