ID   MFR2_SCHPO              Reviewed;         509 AA.
AC   O94411;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 130.
DE   RecName: Full=Meiotic fizzy-related protein 2;
DE   AltName: Full=Meiotically up-regulated gene 55 protein;
GN   Name=mfr2; Synonyms=mug55; ORFNames=SPCC1620.04c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   FUNCTION IN MEIOSIS.
RX   PubMed=16303567; DOI=10.1016/j.cub.2005.10.038;
RA   Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L.,
RA   Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P.,
RA   Smith G.R., Moreno S.;
RT   "A large-scale screen in S. pombe identifies seven novel genes required for
RT   critical meiotic events.";
RL   Curr. Biol. 15:2056-2062(2005).
RN   [3]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Has a role in meiosis. {ECO:0000269|PubMed:16303567}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the WD repeat CDC20/Fizzy family. {ECO:0000305}.
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DR   EMBL; CU329672; CAA22488.1; -; Genomic_DNA.
DR   PIR; T41034; T41034.
DR   RefSeq; NP_588462.1; NM_001023453.2.
DR   AlphaFoldDB; O94411; -.
DR   SMR; O94411; -.
DR   BioGRID; 275828; 4.
DR   STRING; 4896.SPCC1620.04c.1; -.
DR   PaxDb; O94411; -.
DR   EnsemblFungi; SPCC1620.04c.1; SPCC1620.04c.1:pep; SPCC1620.04c.
DR   GeneID; 2539258; -.
DR   KEGG; spo:SPCC1620.04c; -.
DR   PomBase; SPCC1620.04c; -.
DR   VEuPathDB; FungiDB:SPCC1620.04c; -.
DR   eggNOG; KOG0305; Eukaryota.
DR   HOGENOM; CLU_014831_3_3_1; -.
DR   InParanoid; O94411; -.
DR   OMA; YFYDTFR; -.
DR   PhylomeDB; O94411; -.
DR   PRO; PR:O94411; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0032991; C:protein-containing complex; NAS:PomBase.
DR   GO; GO:0010997; F:anaphase-promoting complex binding; IBA:GO_Central.
DR   GO; GO:1990757; F:ubiquitin ligase activator activity; IBA:GO_Central.
DR   GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IDA:PomBase.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:1905786; P:positive regulation of anaphase-promoting complex-dependent catabolic process; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR024977; Apc4_WD40_dom.
DR   InterPro; IPR033010; Cdc20/Fizzy.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19918; PTHR19918; 1.
DR   Pfam; PF12894; ANAPC4_WD40; 1.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Meiosis; Nucleus; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..509
FT                   /note="Meiotic fizzy-related protein 2"
FT                   /id="PRO_0000300505"
FT   REPEAT          159..196
FT                   /note="WD 1"
FT   REPEAT          199..238
FT                   /note="WD 2"
FT   REPEAT          242..281
FT                   /note="WD 3"
FT   REPEAT          287..326
FT                   /note="WD 4"
FT   REPEAT          329..371
FT                   /note="WD 5"
FT   REPEAT          437..477
FT                   /note="WD 6"
SQ   SEQUENCE   509 AA;  58409 MW;  E324ECE2C9A48743 CRC64;
     MIIKKKESFK SPGRLWRVTK IRKLTAAKKN ELQNRKCNQA SNEEKKILYK SNFLDRFIPS
     KANSDAFRIM ENAFTEKLNT QESLLPDILN LNVKGVLHYK DNKKQKTTRL IESTNYQRQT
     IHGASSSLVI EVEENGHLSN MQGSLYETPL RILDAPGLLD DFYISPLAWS TNGELAVALA
     QNVYLWSEIS GPSIMELSPT TYEVSSLAYS SDGGFLAIAR VNGFVEIWNR KTKNNRCDYK
     FHHDGDISCM AWSPINWTLL VGGSTGNIYV YRRTKSMMRR VHTIKKVHQE QVCGLEWNYD
     GTQFASGGND NLVCIFDIDS LENKKFYWIH LAAVKALAFC PWQKSLLAVG TGSNDQQIYF
     YDTFRGHRIH SLFCGAQVTS VIWSRRYKEF CYSLGYSPEG TNSSLIVYRW PQLTKVFDIP
     SAAIDGWGQD LRTIMAIHTH RKYSNNTWEE GEYVVVANSD ETVKFYKIWG NEMQEIHNDR
     VLYREGIFGS HILEMLENIP EQVLTNGVR