ID   MFRN1_BOVIN             Reviewed;         171 AA.
AC   Q3ZBJ8;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Mitoferrin-1;
DE   AltName: Full=Mitochondrial iron transporter 1;
DE   AltName: Full=Solute carrier family 25 member 37;
GN   Name=SLC25A37; Synonyms=MFRN;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Kidney;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mitochondrial iron transporter that specifically mediates
CC       iron uptake in developing erythroid cells, thereby playing an essential
CC       role in heme biosynthesis. The iron delivered into the mitochondria,
CC       presumably as Fe(2+), is then probably delivered to ferrochelatase to
CC       catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with ACB10; this interaction stabilizes SLC25A37 and
CC       enhances the function of SLC25A37 to import mitochondrial iron during
CC       erythroid differentiation. {ECO:0000250|UniProtKB:Q920G8}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; BC103255; AAI03256.1; -; mRNA.
DR   RefSeq; NP_001029721.1; NM_001034549.1.
DR   AlphaFoldDB; Q3ZBJ8; -.
DR   SMR; Q3ZBJ8; -.
DR   STRING; 9913.ENSBTAP00000025426; -.
DR   PaxDb; Q3ZBJ8; -.
DR   GeneID; 523756; -.
DR   KEGG; bta:523756; -.
DR   CTD; 51312; -.
DR   eggNOG; KOG0760; Eukaryota.
DR   InParanoid; Q3ZBJ8; -.
DR   OrthoDB; 1056670at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031966; C:mitochondrial membrane; IBA:GO_Central.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0048250; P:iron import into the mitochondrion; IBA:GO_Central.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   GO; GO:0046985; P:positive regulation of hemoglobin biosynthetic process; ISS:UniProtKB.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 1.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 1.
PE   2: Evidence at transcript level;
KW   Ion transport; Iron; Iron transport; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..171
FT                   /note="Mitoferrin-1"
FT                   /id="PRO_0000235250"
FT   TRANSMEM        45..64
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..125
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        143..163
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          43..131
FT                   /note="Solcar"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..30
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   171 AA;  18492 MW;  9D1AFB8801A4C72C CRC64;
     MELRRGGVGS QARARRMDGD SRDGGGGCKD AGSEDYENLP TSASLSTHMT AGAMAGILEH
     SVMYPVDSVK TRMQSLNPDP KAHYTSVYGA LKKIIRTEGF WRPLRGLNVM MMGAGPAHAM
     YFACYENMKR TLNAVFHHQG NSHLANGICK RLSGVRKVSP STDPSPGFSS L