MFRN1_DANRE
ID MFRN1_DANRE Reviewed; 332 AA.
AC Q287T7;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Mitoferrin-1;
DE AltName: Full=Mitochondrial iron transporter 1;
DE AltName: Full=Protein frascati;
DE AltName: Full=Solute carrier family 25 member 37;
GN Name=slc25a37; Synonyms=frs, mfrn;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, AND MUTAGENESIS OF LEU-46; MET-61; LEU-144; ARG-158 AND
RP TYR-207.
RX PubMed=16511496; DOI=10.1038/nature04512;
RA Shaw G.C., Cope J.J., Li L., Corson K., Hersey C., Ackermann G.E.,
RA Gwynn B., Lambert A.J., Wingert R.A., Traver D., Trede N.S., Barut B.A.,
RA Zhou Y., Minet E., Donovan A., Brownlie A., Balzan R., Weiss M.J.,
RA Peters L.L., Kaplan J., Zon L.I., Paw B.H.;
RT "Mitoferrin is essential for erythroid iron assimilation.";
RL Nature 440:96-100(2006).
CC -!- FUNCTION: Mitochondrial iron transporter that specifically mediates
CC iron uptake in developing erythroid cells, thereby playing an essential
CC role in heme biosynthesis. The iron delivered into the mitochondria,
CC presumably as Fe(2+), is then probably delivered to ferrochelatase to
CC catalyze Fe(2+) incorporation into protoprophyrin IX to make heme.
CC {ECO:0000269|PubMed:16511496}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000269|PubMed:16511496}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:16511496}.
CC -!- TISSUE SPECIFICITY: Highly expressed in hematopoietic organs, Expressed
CC in the intermediate cell mass (ICM), a tissue equivalent to the
CC mammalian extraembryonic yolk-sac blood islands. Colocalizes with
CC gata1. {ECO:0000269|PubMed:16511496}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; DQ112224; ABA33608.1; -; mRNA.
DR EMBL; DQ112225; ABA33609.1; -; mRNA.
DR RefSeq; NP_001035060.1; NM_001039971.1.
DR AlphaFoldDB; Q287T7; -.
DR SMR; Q287T7; -.
DR STRING; 7955.ENSDARP00000090636; -.
DR TCDB; 2.A.29.5.3; the mitochondrial carrier (mc) family.
DR PaxDb; Q287T7; -.
DR PRIDE; Q287T7; -.
DR Ensembl; ENSDART00000099863; ENSDARP00000090636; ENSDARG00000073743.
DR GeneID; 387000; -.
DR KEGG; dre:387000; -.
DR CTD; 51312; -.
DR ZFIN; ZDB-GENE-031118-202; slc25a37.
DR eggNOG; KOG0760; Eukaryota.
DR GeneTree; ENSGT00940000158607; -.
DR HOGENOM; CLU_015166_3_1_1; -.
DR InParanoid; Q287T7; -.
DR OMA; MYNSQHQ; -.
DR OrthoDB; 1056670at2759; -.
DR PhylomeDB; Q287T7; -.
DR TreeFam; TF314118; -.
DR PRO; PR:Q287T7; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 8.
DR Bgee; ENSDARG00000073743; Expressed in mature ovarian follicle and 19 other tissues.
DR ExpressionAtlas; Q287T7; baseline.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031966; C:mitochondrial membrane; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IDA:ZFIN.
DR GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005381; F:iron ion transmembrane transporter activity; IMP:ZFIN.
DR GO; GO:0035162; P:embryonic hemopoiesis; IMP:ZFIN.
DR GO; GO:0048821; P:erythrocyte development; IMP:ZFIN.
DR GO; GO:0043249; P:erythrocyte maturation; IMP:ZFIN.
DR GO; GO:0048250; P:iron import into the mitochondrion; IMP:ZFIN.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR Gene3D; 1.50.40.10; -; 2.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 1: Evidence at protein level;
KW Ion transport; Iron; Iron transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..332
FT /note="Mitoferrin-1"
FT /id="PRO_0000235254"
FT TRANSMEM 33..52
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..113
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..150
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..207
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 222..241
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 289..308
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 31..119
FT /note="Solcar 1"
FT REPEAT 129..213
FT /note="Solcar 2"
FT REPEAT 220..314
FT /note="Solcar 3"
FT MUTAGEN 46
FT /note="L->R: In frs-tq223; induces embryonic hypochronic
FT anemia."
FT /evidence="ECO:0000269|PubMed:16511496"
FT MUTAGEN 61
FT /note="M->K: In frs-tm130; induces embryonic hypochronic
FT anemia."
FT /evidence="ECO:0000269|PubMed:16511496"
FT MUTAGEN 144
FT /note="L->H: In frs-ij001; induces embryonic hypochronic
FT anemia."
FT /evidence="ECO:0000269|PubMed:16511496"
FT MUTAGEN 158
FT /note="R->W: In frs-tg180; induces embryonic hypochronic
FT anemia."
FT /evidence="ECO:0000269|PubMed:16511496"
FT MUTAGEN 207
FT /note="Y->D: In frs-tg221; induces embryonic hypochronic
FT anemia."
FT /evidence="ECO:0000269|PubMed:16511496"
SQ SEQUENCE 332 AA; 36711 MW; 227032AD6BCA8200 CRC64;
MELRTDAVLA SLEMSEPVKN DEDYESLPAH ASLGTHMTAG AVAGILEHTV MYPVDSVKTR
MQSLQPDPKA QYRSVYGALK RIVRTEGLLR PLRGLNITVL GAGPAHALYF ACYERIKRSL
SDVIQNGGNS HIANGVAGSV ATVLHDAVMN PAEVVKQRMQ MYNSPYRSLY DCVLMVSRKE
GLAAFYRSYS TQLTMNIPFQ AVHFITYEFM QEHFNPHRQY RPETHIISGA AAGAVSAAVT
TPLDVCKTLL NTQENVALSS AHVSGHLSGM VNALRTVYRL GGVPAFFKGI QARVIYQMPS
TAIAWSVYEF FKYFLTQHES HVQEVSHKTS PT
