MFRN1_RAT
ID MFRN1_RAT Reviewed; 338 AA.
AC Q66H23;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Mitoferrin-1;
DE AltName: Full=Mitochondrial iron transporter 1;
DE AltName: Full=Solute carrier family 25 member 37;
GN Name=Slc25a37; Synonyms=Mfrn;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Mitochondrial iron transporter that specifically mediates
CC iron uptake in developing erythroid cells, thereby playing an essential
CC role in heme biosynthesis. The iron delivered into the mitochondria,
CC presumably as Fe(2+), is then probably delivered to ferrochelatase to
CC catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with ACB10; this interaction stabilizes SLC25A37 and
CC enhances the function of SLC25A37 to import mitochondrial iron during
CC erythroid differentiation. {ECO:0000250|UniProtKB:Q920G8}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; BC082071; AAH82071.1; -; mRNA.
DR RefSeq; NP_001014018.1; NM_001013996.1.
DR AlphaFoldDB; Q66H23; -.
DR SMR; Q66H23; -.
DR STRING; 10116.ENSRNOP00000021636; -.
DR PhosphoSitePlus; Q66H23; -.
DR PaxDb; Q66H23; -.
DR GeneID; 306000; -.
DR KEGG; rno:306000; -.
DR UCSC; RGD:1359361; rat.
DR CTD; 51312; -.
DR RGD; 1359361; Slc25a37.
DR VEuPathDB; HostDB:ENSRNOG00000015495; -.
DR eggNOG; KOG0760; Eukaryota.
DR HOGENOM; CLU_015166_3_1_1; -.
DR InParanoid; Q66H23; -.
DR OMA; MYNSQHQ; -.
DR OrthoDB; 1056670at2759; -.
DR PhylomeDB; Q66H23; -.
DR TreeFam; TF314118; -.
DR PRO; PR:Q66H23; -.
DR Proteomes; UP000002494; Chromosome 15.
DR Bgee; ENSRNOG00000015495; Expressed in spleen and 18 other tissues.
DR Genevisible; Q66H23; RN.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISO:RGD.
DR GO; GO:0031966; C:mitochondrial membrane; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR GO; GO:0015093; F:ferrous iron transmembrane transporter activity; ISO:RGD.
DR GO; GO:0005381; F:iron ion transmembrane transporter activity; ISO:RGD.
DR GO; GO:0048250; P:iron import into the mitochondrion; ISO:RGD.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR GO; GO:0046985; P:positive regulation of hemoglobin biosynthetic process; ISS:UniProtKB.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Ion transport; Iron; Iron transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..338
FT /note="Mitoferrin-1"
FT /id="PRO_0000235253"
FT TRANSMEM 45..64
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..125
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..162
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..219
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..253
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..320
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 43..131
FT /note="Solcar 1"
FT REPEAT 141..225
FT /note="Solcar 2"
FT REPEAT 232..326
FT /note="Solcar 3"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..30
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 338 AA; 37497 MW; C5F6DE138530700E CRC64;
MELRRGGVGS QAAGRRMDGD CRDGGCGSKD AGSEDYENLP TSASVSTHMT AGAMAGILEH
SIMYPVDSVK TRMQSLNPDP KARYTSIYGA LKRIMHTEGF WRPLRGLNVM MMGAGPAHAM
YFACYENMKR TLNDVFSHQG NSHLANGIAG SMATLLHDAV MNPAEVVKQR LQMYNSQHQS
ALSCIRTVWR TEGLGAFYRS YTTQLTMNIP FQSIHFITYE FLQEQVNPRR DYNPQSHIIS
GGLAGALAAA ATTPLDVCKT LLNTQENMAL SLANVSGRLS GMANAFRTVY QLNGLAGYFK
GIQARVIYQM PSTAISWSVY EFFKYFLTKR QLENRTLY