ID   MFRN_CAEBR              Reviewed;         311 AA.
AC   Q620A6; A8WTA6;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Mitoferrin;
GN   Name=mfn-1 {ECO:0000312|WormBase:CBG02884};
GN   ORFNames=CBG02884 {ECO:0000312|WormBase:CBG02884};
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Mitochondrial iron transporter that mediates iron uptake.
CC       Probably required for heme synthesis of hemoproteins and Fe-S cluster
CC       assembly. {ECO:0000250|UniProtKB:Q9VAY3}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q9VAY3}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q9VAY3}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; HE601438; CAP23717.3; -; Genomic_DNA.
DR   RefSeq; XP_002631109.1; XM_002631063.1.
DR   AlphaFoldDB; Q620A6; -.
DR   SMR; Q620A6; -.
DR   STRING; 6238.CBG02884; -.
DR   EnsemblMetazoa; CBG02884a.1; CBG02884a.1; WBGene00025852.
DR   GeneID; 8572623; -.
DR   KEGG; cbr:CBG_02884; -.
DR   CTD; 8572623; -.
DR   WormBase; CBG02884; CBP00872; WBGene00025852; Cbr-mfn-1.
DR   eggNOG; KOG0760; Eukaryota.
DR   HOGENOM; CLU_015166_3_1_1; -.
DR   InParanoid; Q620A6; -.
DR   OMA; KVMNPSQ; -.
DR   OrthoDB; 1056670at2759; -.
DR   Proteomes; UP000008549; Chromosome II.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031966; C:mitochondrial membrane; IBA:GO_Central.
DR   GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0048250; P:iron import into the mitochondrion; IBA:GO_Central.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   Gene3D; 1.50.40.10; -; 2.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 3.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   3: Inferred from homology;
KW   Ion transport; Iron; Iron transport; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..311
FT                   /note="Mitoferrin"
FT                   /id="PRO_0000235260"
FT   TRANSMEM        17..36
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..96
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        112..132
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        170..189
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        204..223
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        277..296
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          15..102
FT                   /note="Solcar 1"
FT   REPEAT          111..195
FT                   /note="Solcar 2"
FT   REPEAT          202..302
FT                   /note="Solcar 3"
SQ   SEQUENCE   311 AA;  34088 MW;  4D221080C24646BF CRC64;
     MGGGGEDEYE SLPTHSIPVH LAAGALAGAV EHCVMFPFDS VKTRMQSLCP CETKCPTPVH
     SLMSIVKREG WLRPLRGVNA VAAGSMPAHA LYFTVYEKMK SFLTGNTAGH EHTLAYGASG
     VVATLIHDAV MNPAEVVKQR MQMAYSPYGS SLECARCVYN REGFAAFYRS YTTQLAMNVP
     FQAIHFMGYE FWQQVLNPEH KYDPKSHLIA GGLAGGLAAA VTTPMDCVKT VLNTQQAAEA
     DPSNRRIFLK ARYRYRGISD AVRTIYSQRG MAGFSCGLQA RVIFQVPATA LSWSVYELFK
     FMLSFEGGHS S